Results 91 to 100 of about 4,187 (189)

MAGL blocks the action of arachidonic acid in DSE.

, 2012
(A) EPSCs from one WT Purkinje cell plotted over time for control responses (open circles) and test responses (closed circles). Cells were filled with MAGL as indicated by the bar. Representative EPSCs are shown at the right. The percentage inhibition of
De-Juan Wang (141036), Liang Zhou (85586), Xin-Xin Wang (135520), Dong Yang (141041), Cheng-Long Sun (141052), Yin Wang (34938), Li-Da Su (141045), Ying Shen (48310), Lin Zhou (141050), Ya-jun Xie (141048)   +9 more
core   +1 more source

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL) [PDF]

, 2018
As a part of our ongoing research program on compounds from higher plants with lactate dehydrogenase (LDH) and monoacylglycerol lipase (MAGL) inhibitory activities, three new neo-clerodane diterpene 12-deacetylsplendidin C (1), pseudorosmaricin (2), and ...
C. Granchi, N. De Tommasi, A. Braca, Granchi, Carlotta, De Tommasi, Nunziatina, De Leo, Marinella, M. De Leo, B. Alvarado, Poli, Giulio, Braca, Alessandra, G. Poli, Alvarado, Britt, C. Guillen Huallpa, Huallpa, Conny Guillen   +13 more
core   +1 more source

Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing miceResearch in context

EBioMedicine, 2019
Background: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the ...
Silvia Marino, Daniëlle de Ridder, Ryan T. Bishop, Nathalie Renema, Marco Ponzetti, Antonia Sophocleous, Mattia Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, Asim Khogeer, Stuart H. Ralston, Jürg Gertsch, Francois Lamoureux, Dominique Heymann, Nadia Rucci, Aymen I. Idris   +16 more
doaj   +1 more source

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Journal of Neuroinflammation, 2018
Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins ...
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad   +10 more
doaj   +1 more source

Mamilice kao prodavanje magle: ‎Stavovi hrvatskih novinara‎ i urednika‎

Medijske studije
U ovom su radu prikazani stavovi hrvatskih novinara i urednika o mamilicama na temelju po‎lustrukturiranih intervjua provedenih 2023. godine s urednicima i novinarima trojih najčitanijih hrvatskih ‎dnevnih novina, koje imaju i svoje mrežne portale – Jutarnji list, Večernji list i 24sata. Istraživanje je poka‎zalo kako su financijska nužnost i povećanje
Stela Lechpammer, Igor Kanižaj, Boris Beck   +2 more
openaire   +2 more sources

ISPITIVANJA MLAZNICA ZA STVARANJE VODENE MAGLE

Sigurnost : časopis za sigurnost u radnoj i životnoj okolini, 2008
SUMMARY: The paper presents the tests on the water mist nozzles commonly employed in fire extinguishing systems in machinery spaces and pump rooms. The tests were performed according to the procedures defined by the International Maritime Organisation and comprise determination of the flow constant, flow distribution characteristics and the clogging ...
Švaić, Srećko, Dović, Damir
openaire   +2 more sources

DAGLα and MAGL immunoreaction in OHSC 24 h after PPT.

, 2012
Images show the molecular layer (ml), the granular cell layer (gcl) and part of the hilus (hi) region. The enzymes DAGL and MAGL are given in green, GFAP in red and IB4 positive microglial cells are displayed in blue.
Sonja Kallendrusch (109796), Constance Hobusch (109798), Marcin Nowicki (109802), Ingo Bechmann (109810), Marco Koch (109817), Faramarz Dehghani (109822), Simone Ziebell (109806), Gerd Geisslinger (109814), Angela Ehrlich (109799)   +8 more
core   +1 more source

Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2021
openaire   +2 more sources

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

Drug Design, Development and Therapy
Hongqing Zhao,1,2,* Yang Liu,1,2,* Na Cai,3 Xiaolin Liao,1,2 Lin Tang,2,4 Yuhong Wang1,2 1Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Hunan Key Laboratory of ...
Zhao H, Liu Y, Cai N, Liao X, Tang L, Wang Y   +5 more
doaj  

Levels of endocannabinoid metabolizing enzymes are not related with BDNF levels in patients with schizophrenia: a case-controlled study

Psychiatry and Clinical Psychopharmacology, 2019
PURPOSE: While the pathogenesis of schizophrenia has yet to be fully clarified, a huge amount of data suggests the involvement of endocannabinoid system and neurotrophic factors in schizophrenia.
Mehmet Cemal Kaya, Mahmut Bulut, İbrahim Kaplan, Mehmet Gunes   +3 more
doaj   +1 more source