Results 71 to 80 of about 4,187 (189)

Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors [PDF]

, 2016
Monoacylglycerol lipase (MAGL) inhibitors are considered potential therapeutic agents for a variety of pathological conditions, including several types of cancer.
Carlotta Granchi (1375599), Sara Carmignani, Marco Macchia, Adriano Martinelli (809756), Tiziano Tuccinardi (409135), Giuseppe Saccomanni (409134), Clementina Manera, MARTINELLI, ADRIANO, Filippo Minutolo, MINUTOLO, FILIPPO, Carlotta Granchi, Stefano Palazzolo (3345248), MANERA, CLEMENTINA, Clementina Manera (409136), GRANCHI, CARLOTTA, Adriano Martinelli, Flavio Rizzolio, Marco Macchia (409137), Filippo Minutolo (1343184), SACCOMANNI, GIUSEPPE, Flavio Rizzolio (74629), Stefano Palazzolo, Rizzolio, Flavio, TUCCINARDI, TIZIANO, Sara Carmignani (3345245), Tiziano Tuccinardi, Carmignani, Sara, Palazzolo, Stefano, MACCHIA, MARCO, Giuseppe Saccomanni   +29 more
core   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

A Top‐Down View of Global and Regional Carbon Budgets From an Ensemble of Atmospheric Inversions

Global Biogeochemical Cycles, Volume 40, Issue 6, June 2026.
Abstract Atmospheric inversions provide surface CO2 flux estimates based on in situ observed atmospheric CO2 mole fractions or satellite‐based column average CO2 (XCO2). Here, we provide a detailed assessment of 14 atmospheric CO2 inversions included in the Global Carbon Budget (GCB2024).
A. M. van der Woude, I. T. Luijkx, R. J. de Kok, W. Peters, F. Chevallier, C. Rödenbeck, P. Ciais, N. Chandra, K. Wang, R. Janardanan, H. van Asperen, A. Bastos, A. van den Berg, A. A. Bloom, S. Botía, K. Bowman, J. G. Canadell, R. A. F. de Souza, C. Q. Dias‐Junior, L. Feng, P. Friedlingstein, L. V. Gatti, E. Gloor, K. Ishijima, F. Jiang, Z. Jin, W. Ju, X. Lan, J. Liu, Z. Liu, T. Machida, S. Maksyutov, A. C. Manning, A. Martinez, G. A. Martins, K. McKain, J. B. Miller, L. Nayagam, Y. Niwa, P. I. Palmer, P. K. Patra, P. A. Pickers, B. Poulter, B. B. Stephens, C. Sweeney, S. Wofsy, Z. Wu, D. Yang, J. Yun, N. Zeng   +49 more
wiley   +1 more source

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action

Cell Reports, 2015
The endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior.
Andreu Viader, Jacqueline L. Blankman, Peng Zhong, Xiaojie Liu, Joel E. Schlosburg, Christopher M. Joslyn, Qing-Song Liu, Aaron J. Tomarchio, Aron H. Lichtman, Dana E. Selley, Laura J. Sim-Selley, Benjamin F. Cravatt   +11 more
doaj   +1 more source

Toward Closing the Hydroxyl Radical (OH) Budget: Assessing the Feasibility and Uncertainties in Constraining primary OH Production From Space

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 9, 16 May 2026.
Abstract Recent progress in constraining the atmosphere's primary oxidant, the hydroxyl radical (OH), with machine learning (ML) and satellite data raises the intriguing possibility of also constraining individual OH chemical production and loss terms.
Daniel C. Anderson, Bryan N. Duncan, Amir H. Souri, Junhua Liu, Sarah Strode, Doyeon Ahn   +5 more
wiley   +1 more source

Monoacylglycerol lipase (MAGL) Inhibitors

, 2021
The present invention relates to compounds of formula (I) useful as inhibitors, in particular as reversible non-covalent inhibitors, of the enzyme monoacylglycerol lipase (MAGL). The present invention also relates to the therapeutic use of such compounds,
Poli G, Tuccinardi T, Macchia M, Minutolo F, Giordano A, Bononi G, Scalabrini D, Granchi C, Rizzolio F   +8 more
core  

FAAH rs324420 Polymorphism in People With Opioid and Methamphetamine Use Disorders: Psychological Associations

Brain and Behavior, Volume 16, Issue 5, May 2026.
This study explored the association between the FAAH rs324420 polymorphism and substance use disorders in individuals with methamphetamine, opioid, and combined use. The rs324420 CA genotype was linked to a reduced risk of substance use disorder, while higher craving scores were observed in individuals with combined opioid–methamphetamine use. ABSTRACT
Özlem Erekli‐Arat, Meltem Tepe, Selin Özkan‐Kotiloğlu, Mustafa Danışman, Dilek Kaya‐Akyüzlü   +4 more
wiley   +1 more source

The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension‐induced visceral pain models in Rodents

Neurogastroenterology & Motility, 2015
AbstractBackgroundRecent studies showed that the pharmacological inhibition of endocannabinoid degrading enzymes such as fatty acid amide hydrolase (FAAH) and monoacyl glycerol lipase (MAGL) elicit promising analgesic effects in a variety of nociceptive models without serious side effects.
Sakin, Y. S., Dogrul, A., Ilkaya, F., Seyrek, M., Ulas, U. H., Gulsen, M., Bagci, S.   +6 more
openaire   +4 more sources

Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke [PDF]

Stroke, 2018
Background and Purpose— MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins—substances that mediate tissue inflammatory response.
Sang-Ho, Choi, Allison L, Arai, Yongshan, Mou, Byeongteck, Kang, Cecil Chern-Chyi, Yen, John, Hallenbeck, Afonso C, Silva   +6 more
openaire   +2 more sources

Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors. [PDF]

The degradation of the endocannabinoid 2-arachidonoylglycerol is mediated by the enzyme monoacylglycerol lipase (MAGL), thus generating arachidonic acid, the precursor of prostaglandins and other pro-inflammatory mediators.
Vagaggini, Chiara, Chicca, Andrea, Granchi, Carlotta, Brai, Annalaura, Manzi, Simone, Sodi, Andrea, Minutolo, Filippo, Masoni, Samuele, Bononi, Giulia, Gertsch, Jürg, Di Stefano, Miriana, Asif, Kanwal, Poli, Giulio, Tuccinardi, Tiziano, Di Bussolo, Valeria, Rizzolio, Flavio, Caligiuri, Isabella, Macchia, Marco, Gado, Francesca, Meier, Philip, Dreassi, Elena, Galati, Salvatore   +21 more
core   +1 more source