Results 81 to 90 of about 4,187 (189)
Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez +5 more
wiley +1 more source
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184 [PDF]
Pharmacology Biochemistry and Behavior, 2014 The biological actions of the endocannabinoids anandamide and 2-arachidonoyl glycerol (2-AG) are terminated by enzymatic hydrolysis of these lipids via fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. While several selective FAAH inhibitors have been developed and characterized in vitro and in vivo, none of the ...
Alexandre Seillier +2 more
openaire +2 more sources
BMC Cancer, 2023 Background CXC-chemokine receptor 2 (CXCR2) expression was found to be down-regulated on circulating monocytes of cancer patients. Here, we analyze the percentage of CD14+CXCR2+ monocyte subsets in hepatocellular carcinoma (HCC) patients, and investigate
Chong Zhong Liu +6 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
Molecules, 2018 Endocannabinoid-metabolizing enzymes are downregulated in response to lipopolysaccharide (LPS)-induced inflammation in mice, which may serve as a negative feedback mechanism to increase endocannabinoid levels and reduce inflammation.
Brittany N. Szafran +7 more
doaj +1 more source
Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review
Microcirculation, Volume 33, Issue 4, May 2026.ABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Emanuel F. Matias +2 more
wiley +1 more source
, 2011 Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid, 2-arachidonylglycerol (2-AG). MAGL is universally expressed as a ~33 kDa protein.
Ulloa, Nadine
core
Scientific Reports, 2019 Inflammation in the brain and periphery has been associated with stress-related pathology of mental illness. We have shown that prostaglandin (PG) E2, an arachidonic acid-derived lipid mediator, and innate immune receptors Toll-like receptor (TLR) 2/4 ...
Xiang Nie +5 more
doaj +1 more source
Pathological Roles of Astrocytes in Traumatic Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu +7 more
wiley +1 more source
Journal of Phycology, Volume 62, Issue 2, Page 606-622, April 2026.Abstract Pyrophacus horologium belongs to the family Pyrocystaceae and was recently identified as a mixotrophic dinoflagellate capable of feeding on other dinoflagellates. In this study, the growth and feeding responses of P. horologium were investigated under various environmental conditions by providing Heterocapsa niei, its preferred prey.
Min‐jun Seong +4 more
wiley +1 more source