Results 61 to 70 of about 4,187 (189)

Endocannabinoid Metabolism and Traumatic Brain Injury

Cells, 2021
Traumatic brain injury (TBI) represents a major cause of morbidity and disability and is a risk factor for developing neurodegenerative diseases, including Alzheimer’s disease (AD).
Dexiao Zhu, Fei Gao, Chu Chen
doaj   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

The anti-inflammatory and analgesic potential of the probiotic Streptococcus thermophilus via inhibition of endocannabinoid-degrading enzymes: a preliminary in vitro study [PDF]

Exploration of Immunology
Aim: The benefit of topical application of probiotics on pain and itching associated with skin disorders has become an increasingly intriguing topic in recent years.
Serena Altamura, Elona Dybeli, Francesca Lombardi, Paola Palumbo, Francesca Rosaria Augello, Skender Topi, Maria Grazia Cifone, Benedetta Cinque   +7 more
doaj   +1 more source

High‐Resolution Climate Simulations Over the Eastern Mediterranean Black Sea Region Using the Pseudo‐Global Warming Method With a CMIP6 Ensemble: Wind Energy Resource Availability

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 12, 28 June 2026.
Abstract Weather‐dependent renewable energy resources are already vulnerable to climate change. High‐resolution regional climate simulations are essential for accurately assessing how climate change may impact wind energy resources, particularly in regions with complex topography.
I. Isik‐Cetin, I. Yücel, S. Ç. Bağçacı, M. T. Yılmaz   +3 more
wiley   +1 more source

单酰基甘油脂肪酶在子宫内膜癌中作用机制的研究进展

Zhongguo shiyan zhenduanxue, 2020
单酰基甘油脂肪酶（MAGL）是一种重要的脂代谢酶,它主要在脂类的分解和代谢途径中发挥效用,通过水解单酰基甘油,从而产生游离脂肪酸（FFAs）[1-3]。研究表明[4]MAGL在肿瘤的进展中拥有不可忽视的调节作用,假如将MAGL敲低,肿瘤细胞的增殖显然也表现出被抑制的结果。根据女性生殖道肿瘤中MAGL的表达特点,本文就MAGL在子宫内膜恶性肿瘤中的表达以及MAGL对癌细胞生长的影响的研究成果予以综述。
姜莹, 刘爱民
doaj  

Atmospheric Dust Transport to High‐Elevation Dronning Maud Land, Antarctica, Modulated by Cyclonic Circulation, the Pacific Decadal Oscillation, and Source Emissions

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 11, 16 June 2026.
Abstract The dependence of aeolian dust transport on atmospheric circulation patterns allows dust preserved in Antarctic ice cores to serve as a proxy for past circulation variability. Here, we investigate dust transport to high‐elevation Dronning Maud Land (DML) in Antarctica through analysis of the 1300‐year‐old ISOL‐ICE ice core dust record together
K. C. Henson, V. H. L. Winton, K. R. Clem, R. Mulvaney, M. M. Frey   +4 more
wiley   +1 more source

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors [PDF]

, 2016
This study reports on a preliminary structure-activity relationship exploration of 4-aryliden-2-methyloxazol-5(4H)-one-based compounds as MAGL/FAAH inhibitors.
Giordano A, Bordoni, Vittorio, Caligiuri I, Granchi, Carlotta, Manera, Clementina, GIORDANO, ANTONIO, Minutolo, Filippo, Rizzolio F, Martinelli, Adriano, Tuccinardi, Tiziano, RIZZOLIO, FLAVIO, Caligiuri, Isabella, Macchia, Marco   +12 more
core   +1 more source

MAGLi 432 inhibits MAGL activity and robustly enhances 2-AG levels in human NVU cells.

, 2022
(A) Dose-dependent inhibition of active MAGL by MAGLi 432 in human BMECs (hCMEC/D3), astrocytes (pHA) and pericytes (pHP) in vitro assessed by ABPP and western blot applied to cell lysates 6 h after exposure to ascending doses of MAGLi 432 (10 nM, 100 nM,
Dominik Heer (2169148), Matthias Wittwer (19991), Iris Ruf (13767197), Jörg Benz (13767200), Ludovic Collin (3437399), Benoit Hornsperger (1503058), Bernd Kuhn (260084), Alicia M. Kemble (8555517), Hans Richter (2364346), Britta Engelhardt (307404), Uwe Grether (1594096)   +10 more
core   +1 more source

Inhibition of Monoacylglycerol Lipase Decreases Angiogenic Features of Endothelial Cells via Release of Tissue Inhibitor of Metalloproteinase-1 from Lung Cancer Cells

Cells, 2023
Despite the well-described anticarcinogenic effects of endocannabinoids, the influence of the endocannabinoid system on tumor angiogenesis is still debated.
Felix Wittig, Lino Henkel, Jan Lukas Prüser, Jutta Merkord, Robert Ramer, Burkhard Hinz   +5 more
doaj   +1 more source

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source