Results 51 to 60 of about 4,187 (189)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
LPS modifies active and total MAGL protein expression in a cell-specific manner.
, 2022 Quantification of effects of HBSS (solvent control) and LPS (50ng and 100ng) in vitro by MAGLi 432 in human NVU cells (hCMEC/D3, pHA and pHP) (from Fig 4A and 4B).
Dominik Heer (2169148) +10 more
core +1 more source
Physiological Reports, 2023 The endocannabinoid system (eCS) plays critical roles in locomotor function and motor development; however, the roles of non‐canonical cannabinoid receptor systems such as transient receptor potential (TRP) channels and the Sonic Hedgehog (SHH) signaling
Lakhan S. Khara, Declan W. Ali
doaj +1 more source
Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways
British Journal of Pharmacology, EarlyView.Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck +1 more
wiley +1 more source
The distribution and time-dependent expression of MAGL during skeletal muscle wound healing in rats [PDF]
, 2015 Monoacylglycerol lipase (MAGL) is widely distributed in mammals and largely responsible for metabolizing 2-arachidonoylglycerol (2-AG). Little is known about its expression in skeletal muscles after trauma.
Zhang, Miao +8 more
core +1 more source
EJNMMI Research, 2022 Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system.
Ryosuke Arakawa +19 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus +7 more
wiley +1 more source
Synthesis of glycoconjugated benzoylpiperidines as potential reversible MAGL inhibitors
, 2023 Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase that catalyzes the degradation of the major endocannabinoid neurotransmitter, 2-arachidonoylglycerol, implicated in many physiological and pathological processes, such as pain, inflammation ...
BERTINI, FEDERICA
core
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source
3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors
Journal of Pharmacy and Bioallied Sciences, 2014 Purpose: The purpose of this study is to build up the 3D pharmacophore of Monoacylglycerol lipase (MAGL) inhibitor and to provide the basis to design the novel and potent MAGL inhibitors.
Obaid Afzal +4 more
doaj +1 more source