Results 101 to 110 of about 4,187 (189)
, 2019 Cannabinoids have analgesic and anti-inflammatory properties. For example, in preclinical models of acute inflammatory pain, cannabinoid receptor subtype 2 (i.e., CB2, Table 1) agonists decrease paw inflammation and resulting pain.
Steele, Floyd Franklin, III
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Watermelon: setup and validation of an in silico fragment-based approach
Journal of Enzyme Inhibition and Medicinal ChemistryWe present a new computational approach, named Watermelon, designed for the development of pharmacophore models based on receptor structures. The methodology involves the sampling of potential hotspots for ligand interactions within a protein target’s ...
Miriana Di Stefano +8 more
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Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid, 2-arachidonylglycerol (2-AG). MAGL is universally expressed as a ~33 kDa protein.
Ulloa, Nadine
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Heterocyclic Compounds as Monoacylglycerol Lipase (MAGL) Inhibitors [PDF]
ACS Medicinal Chemistry Letters, 2021 openaire +2 more sources
, 2019 Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling.
Akihiro Takano (1408837) +17 more
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Synthesis and biological evaluation of benzoylpiperidine derivatives as MAGL inhibitors
Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase that plays a major role in the degradation of 2-arachidonoylglycerol, an endocannabinoid neurotransmitter implicated in many physiological and pathological processes, such as pain ...
BONONI, GIULIA
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, 2022 Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder characterized by intrusive memories among other symptoms. Fear conditioning is an associative learning paradigm used as an animal model for PTSD.
Farooq, Muhammad Ali
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Monoacylglycerol lipase ZmMAGL is required to maintain photosynthesis and growth at low temperature
Crop JournalThe monoacylglycerol lipase (MAGL) is a key enzyme in the lipid metabolism pathway which products fatty acids and could play an important role in plant growth and stimulus response.
Ming Yang +9 more
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Discovery and optimization of benzoylpiperidine derivatives as new reversible, potent and selective MAGL inhibitors [PDF]
, 2018 The serine hydrolase monoacylglycerol lipase (MAGL) is the main responsible of the degradation of 2-arachidonoylglycerol, an endocannabinoid implicated in several physiological processes.
Filippo Minutolo +5 more
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