Results 71 to 80 of about 13,706 (225)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

On the properties of single-separator MHS equilibria and the nature of separator reconnection [PDF]

, 2015
This thesis considers the properties of MHS equilibria formed through non-resistive MHD relaxation of analytical non-potential magnetic field models, which contain two null points connected by a generic separator. Four types of analytical magnetic fields
Stevenson, Julie E. H.
core  

Gyrofluid simulations of collisionless reconnection in the presence of diamagnetic effects [PDF]

, 2010
International audienceThe effects of the ion Larmor radius on magnetic reconnection are investigated by means of numerical simulations, with a Hamiltonian gyrofluid model. In the linear regime, it is found that ion diamagnetic effects decrease the growth
Tassi, Emanuele, Grasso, D., F L Waelbroeck, Waelbroeck, F., D Grasso, Tassi, Emanuele Giovanni, E Tassi, Waelbroeck, F.L., Grasso, Daniela, Waelbroeck F. L.   +9 more
core   +1 more source

Radiative Signatures of Magnetic Reconnection: An Approach to Remote Probing of Reconnection Dynamics

The Astrophysical Journal
Magnetic reconnection drives a wide range of astrophysical phenomena, including geomagnetic storms, solar flares, and activity in blazars. However, direct measurement of key reconnection observables remains challenging due to the remote and extreme ...
Sergey K. Ermakov, Michael Bussmann, Alexander Debus, Richard Pausch, Ulrich Schramm, René Widera, Klaus Steiniger   +6 more
doaj   +1 more source

Impact of Carina Width on Re‐Ablation Rate of Atrial Fibrillation After Primary Cryoballoon‐Ablation

Journal of Cardiovascular Electrophysiology, EarlyView.
Right side carina width is associated with the incidence of reconnection of RPVs and re‐ablation. Increased left side carina width was associated with re‐ablation rate, but there was no association with reconnection of the LPVs. ABSTRACT Background Reconnection of the pulmonary veins (PVs) is the primary cause of atrial fibrillation (AF) episodes after
Miriam Müller, Marja Hedman, Marianne Heikkilä, Juhani Junttila   +3 more
wiley   +1 more source

Design and construction of Keda collisionless Reconnection eXperiment

地球与行星物理论评
The collisionless Keda Reconnection eXperiment (KRX) is a comprehensive platform for ground-base simulations of basic physical processes in a space environment.
Qiaofeng Zhang, Jinlin Xie, Longlong Sang, Fa Yang, Lei Tang, Ziyi Bai, Youran Liu, Shihang Hu, Quanming Lu   +8 more
doaj   +1 more source

Navigating the Zero Fluoroscopy Frontier: Current Tools, Evidence and Future Directions in Electrophysiology Procedures

Pacing and Clinical Electrophysiology, EarlyView.
Graphical Abstract ABSTRACT Fluoroscopy has traditionally been the mainstay imaging technique for guidance during electrophysiology (EP) ablation procedures. The numerous disadvantages associated with radiation exposure for both operators and patients have created the need for zero‐fluoroscopy (ZF) approaches. Today, electrophysiologists have access to
Dimitrios Kotzadamis, Georgios Giannopoulos, Vaios Schismenos, Alexandros Evangeliou, Prokopios Mamolis, Antonios Antoniadis, Vassilios Vassilikos   +6 more
wiley   +1 more source

Current sheet formation and nonideal behavior at three-dimensional magnetic null points [PDF]

, 2007
The nature of the evolution of the magnetic field, and of current sheet formation, at three-dimensional (3D) magnetic null points is investigated. A kinematic example is presented that demonstrates that for certain evolutions of a 3D null (specifically ...
Bhattacharjee, A., Pontin, D. I., Pontin, DI., D. I. Pontin, A. Bhattacharjee, Bhattacharjee, Amitava, Galsgaard, Klaus, K. Galsgaard   +7 more
core   +1 more source

Magnetohydrodynamics simulation of magnetic reconnection process based on the laser-driven Helmholtz capacitor-coil targets

Frontiers in Physics
Magnetic reconnection is an important rapid energy release mechanism in astrophysics. Magnetic energy can be effectively converted into plasma kinetic energy, thermal energy, and radiation energy.
Chunqing Xing, Yongli Ping, Yongli Ping, Xu Zhao, Xu Zhao, Weiming An, Weiming An, Jiayong Zhong, Jiayong Zhong   +8 more
doaj   +1 more source

Recent Progress in Understanding Solar Magnetic Reconnection [PDF]

Journal of Astronomy and Space Sciences, 2015
Magnetic reconnection is a fundamental process occurring in a wide range of astrophysical, heliospheric and laboratory plasmas. This process alters magnetic topology and triggers rapid conversion of magnetic energy into thermal heating and nonthermal ...
Jeongwoo Lee
doaj   +1 more source