Results 71 to 80 of about 2,403,839 (289)

A Review of Pavement Condition Evaluation Index Systems in China and Abroad

Zhongwai Gonglu
With the increasingly complex operating conditions of roads, it has become a consensus among countries to improve the accuracy and systematicness of maintenance decisions.
CHEN Leilei, YANG-LI Wenyun, LI Wei, Muhammad Thlha, QIAN Zhendong   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Automated preventive maintenance program [PDF]

, 1971
Maintenance program which is concise and inexpensive to operate adapts to almost any system that has a FORTRAN compiler. Program operates on a stored data base with an output consisting of scheduling information and various management ...
Cea, E. J., Grieger, T. H.
core   +1 more source

VLED and formula LED in the management of type 2 diabetes: defining the clinical need and research requirements [PDF]

, 2011
It has been known for many years that substantial weight loss, achieved by bariatric surgery or non-surgical means can mean normalise glucose tolerance.
Lean, M.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

MODERN MANAGEMENT METHODS FOR EQUIPMENT MAINTENANCE [PDF]

The concept of maintenance in the field of complex equipment wasdeveloped in the USA being quickly adopted by European countries and Japan. TheAmerican maintenance concept has the significance of creating a support system forindustrial equipment ...
Ciprian Cucu, Ioan Cucu
core  

The Unseen Face of E-Business Project Development [PDF]

, 2003
The purpose of this paper is intent on identify and analyze the unseen factors of successful or failure of e-business project development. The IT managers must take into account both all costs involved in e-business development and all phases (analysis ...
A Drobik, C T Coward, D. -E-Business Chaffey, Gabriela Mesnita, J Charvart, J N Luftman, J Ryan, J Treese, M V Deise, P D Dutton, P Kulik, R Kalakota, R Kalakota, R Plant, S S Hejazi, Standish Group, Tiberiu Vasilica, Z Gordjin   +17 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Performance Rate Analysis in Photovoltaic Solar Plants by Machine Learning

Advanced Energy & Sustainability Research
Photovoltaic (PV) solar plants require conditions monitoring systems and advanced analytics to enhance performance and reliability. Supervisory control and data acquisition systems are widely applied in PV solar plants to ensure suitable maintenance ...
Alba Muñoz del Rio, Isaac Segovia Ramírez, Fausto Pedro García Márquez   +2 more
doaj   +1 more source