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MAIT cells as attractive vaccine targets
FEBS Letters, 2019Mucosal‐associated invariant T (MAIT) cells are a subset of T cells that perform innate‐like immunity functions upon recognition of small molecule vitamin B metabolites presented by the MHC, class I‐related protein‐1 (MR1). MAIT cells are profuse in humans, but especially abundant in blood, liver, lungs, and mucosal layers.
A. Michael Downey +2 more
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MAIT cells and MR1-antigen recognition
Current Opinion in Immunology, 2017Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector ...
Andrew N, Keller +4 more
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AbstractIn humans, MAIT cells represent the most abundant T‐cell subset reacting against bacteria. MAIT cells belong to the evolutionarily conserved family of “preset” T cells that includes also NKT cells. Both subsets are selected by double positive thymocytes leading to common features such as PLZF expression.
Olivier Lantz, François Legoux
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MAIT Cell Activation by Fungal Pathogens
2019MAIT cells can recognize and respond to several pathogens in a distinct manner. However, many studies are focused on activation by bacteria and by viruses, while reports about molds and MAIT cells are rare. Here, we describe a method to investigate MAIT cell interaction with filamentous fungi from Aspergillus and Mucorales species.
Susanne, Jahreis +2 more
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Activation and Function of iNKT and MAIT Cells
2015Over the last two decades, it has been established that peptides are not the only antigens recognized by T lymphocytes. Here, we review information on two T lymphocyte populations that recognize nonpeptide antigens: invariant natural killer T cells (iNKT cells), which respond to glycolipids, and mucosal associated invariant T cells (MAIT cells), which ...
Shilpi, Chandra, Mitchell, Kronenberg
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Reprogramming of MAIT Cells to Pluripotency and Redifferentiation
2019Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) consists in dedifferentiation of the cells into the pluripotent state, i.e., stem cells. Since T cells play a pivotal role in our immune system, T cell reprogramming into iPSCs and subsequent redifferentiation of iPSCs toward the original cells hold a great promise for ...
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Charting MAIT cell development
Science, 2019T Cells Mucosal-associated invariant T (MAIT) cells are a distinct subset of T cells that recognize vitamin B metabolites presented by major histocompatibility complex class I–related protein (MR1). Koay et al. used bulk and single-cell RNA sequencing and flow cytometric analysis to characterize the development of murine and human MAIT cells.
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Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin
Cell, 2023Benjamin Ruf, Lichun Ma, Mahler Revsine
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