Results 31 to 40 of about 332 (158)
Synthesis of the WXYZA′ Domain of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 A synthesis of the WXYZA' domain (7) of the marine neurotoxin maitotoxin (1) is reported. The convergent synthetic strategy involves construction of key building blocks 11 and 12, their coupling, and the elaboration of the resulting ester (10) to the target molecule through a ring-closing metathesis and a hydroxy dithioketal cyclization as the key ...
K C, Nicolaou +2 more
openaire +2 more sources
, 2023 Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa.
core +1 more source
Maitotoxin, a potent, general activator of phosphoinositide breakdown [PDF]
FEBS Letters, 1989 Maitotoxin (MTX), a potent marine toxin, elicits a calcium‐dependent activation of cells that can be inhibited by calcium channel blockers like nifedipine. MTX also stimulates phosphoinositide breakdown in smooth muscle cells, NCB‐20 cells and PC12 cells through a nifedipine‐insensitive mechanism.
Gusovsky, Fabian +2 more
openaire +2 more sources
Alternative method to detect compounds produced by Gambierdiscus spp.
Frontiers in Marine Science, 2014 Ciguatoxins (CTXs) and CTX precursors are produced by several Gambierdiscus spp. These polyether toxins are associated to ciguatera fish poisoning (CFP). In addition to CTX, maitotoxins (MTX) and gambierol are also produced by these dinoflagellates.
Jon Andoni Sánchez
doaj +1 more source
Synthesis of the C′D′E′F′ Domain of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 A devised biomimetic strategy toward the C'D'E'F' domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all attempts to induce the desired cascade to form the targeted compound through a zip-type reaction under neutral or acidic conditions failed, prompting adoption of a linear stepwise approach to 6 ...
K C, Nicolaou +3 more
openaire +2 more sources
Further Advance of Gambierdiscus Species in the Canary Islands, with the First Report of Gambierdiscus belizeanus [PDF]
, 2020 Ciguatera Poisoning (CP) is a human food-borne poisoning that has been known since ancient times to be found mainly in tropical and subtropical areas, which occurs when fish or very rarely invertebrates contaminated with ciguatoxins (CTXs) are consumed ...
Andree, Karl B. +7 more
core +1 more source
Marine Toxins from Harmful Algae and Seafood Safety [PDF]
, 2023 The rapid expansion of aquaculture around the world is increasingly being impacted by toxins produced by harmful marine microalgae, which threaten the safety of seafood.
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Synthesis of the ABCDEFG Ring System of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 Maitotoxin (1) continues to fascinate scientists not only because of its size and potent neurotoxicity but also due to its molecular architecture. To provide further support for its structure and facilitate fragment-based biological studies, we developed an efficient chemical synthesis of the ABCDEFG segment 3 of maitotoxin.
K C, Nicolaou +3 more
openaire +2 more sources
Assessment of cytotoxicity in ten strains of Gambierdiscus australes from Macaronesian Islands by neuro-2a cell-based assays [PDF]
, 2018 Within the dinoflagellate genus Gambierdiscus several species are well-known producers of ciguatoxins (CTXs) and maitotoxins (MTXs). These compounds are potent marine toxins that accumulate through the food chain, leading to a foodborne disease known as ...
Andree, Karl B. +6 more
core +1 more source
Contribution to the risk assessment of ciguatera poisoning in europe (the balearic and Canary Islands and Madeira archipelago) [PDF]
, 2021 Actualment, la intoxicació alimentaria de la ciguatera (CP) es considera una malaltia emergent a les zones temperades d'Europa. La present tesi contribueix a l'avaluació del risc d'intoxicació per ciguatera a les Illes Balears (Mediterrània Occidental),
Tudó Casanova, Àngels
core