Multiple Loci within the major histocompatibility complex confer risk of psoriasis. [PDF]
PLoS Genetics, 2009 Psoriasis is a common inflammatory skin disease characterized by thickened scaly red plaques. Previously we have performed a genome-wide association study (GWAS) on psoriasis with 1,359 cases and 1,400 controls, which were genotyped for 447,249 SNPs. The
Bing-Jian Feng +13 more
doaj +6 more sources
A nonpolymorphic class I gene in the murine major histocompatibility complex [PDF]
, 1984 DNA sequence analysis of a class I gene (QlO), which maps to the Qa2,3 locus in the C57BL/lO (H- 2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library.
Andrew L. Mellor +4 more
openalex +3 more sources
Major Histocompatibility Complex-B haplotype and ovarian graft response
Poultry Science, 2023 : Gonadal tissue transfer is considered one of the best methods to preserve genetic variability. Poultry hosts can receive a gonad from a donor of a different genetic background, sustain the growth of this graft, and produce gametes from it ...
Chi Cuong Quach +5 more
doaj +1 more source
Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]
, 1994 Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold +45 more
core +1 more source
Impact of Antigen Presentation Mechanisms on Immune Response in Autoimmune Hepatitis
Frontiers in Immunology, 2022 The liver is a very tolerogenic organ. It is continually exposed to a multitude of antigens and is able to promote an effective immune response against pathogens and simultaneously immune tolerance against self-antigens. In spite of strong peripheral and
Rossella Fasano +10 more
doaj +1 more source
Cholesterol lowering drug may influence cellular immune response by altering MHC II function[S]
Journal of Lipid Research, 2013 Major histocompatibility complex class II (MHC II) expressed on the surface of antigen-presenting cells (APCs) displays peptides to CD4+ T cells. Depletion of membrane cholesterol from APCs by methyl β-cyclodextrin treatment compromises peptide-MHC II ...
Koushik Roy +4 more
doaj +1 more source
Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males [PDF]
, 2013 Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring variability at key loci after mating. However, the role of these genetic benefits in cryptic female choice remains poorly understood. Female red junglefowl, Gallus
Alcaide M +8 more
core +1 more source
Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]
, 2004 Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Araibi, E.H. +3 more
core +1 more source
Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation
Frontiers in Veterinary Science, 2022 Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu +43 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Arterial bypass and interposition grafts are used routinely across multiple surgical subspecialties. Current options include both autologous and synthetic materials; however, each graft presents specific limitations.
John P. Maufort +12 more
doaj +3 more sources