Results 21 to 30 of about 680,011 (354)

Modification of Cysteine Residues In Vitro and In Vivo Affects the Immunogenicity and Antigenicity of Major Histocompatibility Complex Class I–restricted Viral Determinants

Journal of Experimental Medicine, 1999
In studying the subdominant status of two cysteine-containing influenza virus nuclear protein (NP) determinants (NP39–47 and NP218–226) restricted by H-2Kd, we found that the antigenicity of synthetic peptides was enhanced 10–100-fold by treatment with ...
Weisan Chen, J. Yewdell, Rodney L. Levine, J. Bennink   +3 more
semanticscholar   +1 more source

Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males [PDF]

, 2013
Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring variability at key loci after mating. However, the role of these genetic benefits in cryptic female choice remains poorly understood. Female red junglefowl, Gallus
Alcaide M, Bakst MR, Burnham KP, Etches RJ, Janeway CA, Klein J, Olsson M, Parker GA, Trivers RL   +8 more
core   +1 more source

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B.   +3 more
core   +1 more source

The major histocompatibility complex of reindeer

Rangifer, 1990
The major histocompatibility complex (MHC) is a system of closely linked genes showing an extremely high degree of polymorphism. These genes are major elements in the government of specific immune reactions.
I. Olsaker, K. H. Røed
doaj   +1 more source

A Nonpolymorphic Class I Gene in the Murine Major Histocompatibility Complex [PDF]

, 1984
DNA sequence analysis of a class I gene (QlO), which maps to the Qa2,3 locus in the C57BL/lO (H- 2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library.
Flavell, Richard A., Jay, Gilbert, Kress, Michael, Mellor, Andrew L., Weiss, Elisabeth H.   +4 more
core   +1 more source

Major Histocompatibility Complex–Matched Arteries Have Similar Patency to Autologous Arteries in a Mauritian Cynomolgus Macaque Major Histocompatibility Complex–Defined Transplant Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Arterial bypass and interposition grafts are used routinely across multiple surgical subspecialties. Current options include both autologous and synthetic materials; however, each graft presents specific limitations.
John P. Maufort, Jacqueline S. Israel, Matthew E. Brown, Steve J. Kempton, Nicholas J. Albano, Weifeng Zeng, Laurel E. Kelnhofer, Matthew R. Reynolds, Elizabeth S. Perrin, Ruston J. Sanchez, Igor I. Slukvin, James A. Thomson, Samuel O. Poore   +12 more
doaj   +3 more sources

Congruence as a measurement of extended haplotype structure across the genome

Journal of Translational Medicine, 2012
Background Historically, extended haplotypes have been defined using only a few data points, such as alleles for several HLA genes in the MHC. High-density SNP data, and the increasing affordability of whole genome SNP typing, creates the opportunity to ...
Baschal Erin E, Jasinski Jean M, Boyle Theresa A, Fain Pamela R, Eisenbarth George S, Siebert Janet C   +5 more
doaj   +1 more source

A diploid assembly-based benchmark for variants in the major histocompatibility complex

Nature Communications, 2019
Most human genomes are characterized by aligning individual reads to the reference genome, but accurate long reads and linked reads now enable us to construct accurate, phased de novo assemblies.
C. Chin, Justin Wagner, Qiandong Zeng, Erik K. Garrison, S. Garg, Arkarachai Fungtammasan, M. Rautiainen, T. Marschall, Alexander T. Dilthey, J. Zook   +9 more
semanticscholar   +1 more source

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

Journal of Experimental Medicine, 1991
Interleukin 10 (IL-10) and viral IL-10 (v-IL-10) strongly reduced antigen-specific proliferation of human T cells and CD4+ T cell clones when monocytes were used as antigen-presenting cells.
R. D. Malefyt, J. Haanen, H. Spits, M. Roncarolo, A. Velde, C. Figdor, K. E. Johnson, R. Kastelein, H. Yssel, J. D. Vries   +9 more
semanticscholar   +1 more source

Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]

, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
core   +1 more source