Results 21 to 30 of about 991,100 (420)

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products

Journal of Experimental Medicine, 1995
We have previously demonstrated that human peripheral blood low density mononuclear cells cultured in granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4 develop into dendritic cells (DCs) that are extremely efficient in ...
F. Sallusto, M. Cella, Carlo Danieli, A. Lanzavecchia   +3 more
semanticscholar   +1 more source

Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]

, 1994
Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold, Billingham, Billingham, Billingham, Calne, Calne, Cohen, Corry, Coutinho, Dahmen, Davies, Demetris, Demetris, Garnier, Goulmy, Hoffmann, Houssaint, Jerne, Kamada, Liegeois, Liegeois, Mayumi, Monaco, Monaco, Murase, Ono, Peacock, Perelson, Qian, Rao, Russell, Russell, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steinman, Steinman, Strelein, Thomas, Wood, Zimmerman   +45 more
core   +1 more source

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Frontiers in Immunology, 2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek, Esam T. Abualrous, J. Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, F. Noé, C. Freund   +6 more
semanticscholar   +1 more source

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B.   +3 more
core   +1 more source

A diploid assembly-based benchmark for variants in the major histocompatibility complex

Nature Communications, 2019
Most human genomes are characterized by aligning individual reads to the reference genome, but accurate long reads and linked reads now enable us to construct accurate, phased de novo assemblies.
C. Chin, Justin Wagner, Qiandong Zeng, Erik K. Garrison, S. Garg, Arkarachai Fungtammasan, M. Rautiainen, T. Marschall, A. Dilthey, J. Zook   +9 more
semanticscholar   +1 more source

Major Histocompatibility Complex–Matched Arteries Have Similar Patency to Autologous Arteries in a Mauritian Cynomolgus Macaque Major Histocompatibility Complex–Defined Transplant Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Arterial bypass and interposition grafts are used routinely across multiple surgical subspecialties. Current options include both autologous and synthetic materials; however, each graft presents specific limitations.
John P. Maufort, Jacqueline S. Israel, Matthew E. Brown, Steve J. Kempton, Nicholas J. Albano, Weifeng Zeng, Laurel E. Kelnhofer, Matthew R. Reynolds, Elizabeth S. Perrin, Ruston J. Sanchez, Igor I. Slukvin, James A. Thomson, Samuel O. Poore   +12 more
doaj   +3 more sources

Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations [PDF]

, 2012
The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle.
A Ding, B Koskella, C Berenos, C Eizaguirre, C Eizaguirre, C Hess, C Loiseau, CM Lively, E Decaestecker, G Sorci, H Westerdahl, J Lohm, J Robinson, KM Wegner, L Bernatchez, L Van Valen, LG Spurgin, M Kalbe, M Milinski, N Charbonnel, N Takahata, R Ekblom, RD Schulte, RDH Barrett, RJ De Boer, RS Howard, RW Slade, SV Edwards, TL Lenz, TL Lenz, W Hamilton, WD Hamilton   +31 more
core   +2 more sources

Congruence as a measurement of extended haplotype structure across the genome

Journal of Translational Medicine, 2012
Background Historically, extended haplotypes have been defined using only a few data points, such as alleles for several HLA genes in the MHC. High-density SNP data, and the increasing affordability of whole genome SNP typing, creates the opportunity to ...
Baschal Erin E, Jasinski Jean M, Boyle Theresa A, Fain Pamela R, Eisenbarth George S, Siebert Janet C   +5 more
doaj   +1 more source

Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation

Frontiers in Veterinary Science, 2022
Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Honghao Yu, Shuhan Chen, Shuhan Chen, Shuhan Chen, Yaxuan Zhang, Yaxuan Zhang, Yaxuan Zhang, Jianxiong Guo, Jianxiong Guo, Chang Yang, Chang Yang, Deling Jiao, Deling Jiao, Deling Jiao, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Heng Zhao, Heng Zhao, Heng Zhao, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Taiyun Wei, Taiyun Wei, Honghui Li, Honghui Li, Honghui Li, Baoyu Jia, Baoyu Jia, Baoyu Jia, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Hong-Ye Zhao, Hong-Ye Zhao, Xingxu Huang, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +43 more
doaj   +1 more source

Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males [PDF]

, 2013
Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring variability at key loci after mating. However, the role of these genetic benefits in cryptic female choice remains poorly understood. Female red junglefowl, Gallus
Alcaide M, Bakst MR, Burnham KP, Etches RJ, Janeway CA, Klein J, Olsson M, Parker GA, Trivers RL   +8 more
core   +1 more source