Congruence as a measurement of extended haplotype structure across the genome
Journal of Translational Medicine, 2012 Background Historically, extended haplotypes have been defined using only a few data points, such as alleles for several HLA genes in the MHC. High-density SNP data, and the increasing affordability of whole genome SNP typing, creates the opportunity to ...
Baschal Erin E +5 more
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A Nonpolymorphic Class I Gene in the Murine Major Histocompatibility Complex [PDF]
, 1984 DNA sequence analysis of a class I gene (QlO), which maps to the Qa2,3 locus in the C57BL/lO (H- 2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library.
Flavell, Richard A. +4 more
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Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]
, 2018 CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar +7 more
core +6 more sources
Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]
, 2004 Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
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Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA [PDF]
, 1986 Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC ...
Boral, Anthony +11 more
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Journal of Lipid Research, 2006 Although the immune system, inflammation, and cellular metabolism are linked to diseases associated with dyslipidemias, the mechanism(s) remain unclear.
S.C. Schweitzer +7 more
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Two polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteins [PDF]
, 2014 Major histocompatibility complex class I molecules (MHC I) present peptides to cytotoxic T-cells at the surface of almost all nucleated cells. The function of MHC I molecules is to select high affinity peptides from a large intracellular pool and they ...
Bailey, Alistair +3 more
core +3 more sources
Трансплантология (Москва), 2023 Aim. To reveal the significance of the major histocompatibility complex and the human leukocyte antigen evolutionary divergence in transplantation of allogeneic hematopoietic stem cells.
F. A. Omarova +2 more
doaj +1 more source
Evolution of major histocompatibility complex gene copy number.
PLoS Computational Biology, 2019 MHC genes, which code for proteins responsible for presenting pathogen-derived antigens to the host immune system, show remarkable copy-number variation both between and within species.
Piotr Bentkowski, Jacek Radwan
doaj +1 more source
MHC Class I+/II− Dendritic Cells Induce Hapten-Specific Immune Responses In Vitro and In Vivo [PDF]
, 1978 Activation requirements and biologic properties of hapten-specific, major histocompatibility complex class I-restricted CD8+ T lymphocytes are not fully understood.
Andrea Kolesaric +25 more
core +1 more source