Results 41 to 50 of about 991,100 (420)

Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]

, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
core   +1 more source

Population variability in the generation and thymic selection of T-cell repertoires [PDF]

PLoS Computational Biology 16(12) e1008394 (2020), 2020
The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented on the major histocompatibility complex.
arxiv   +1 more source

Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

Journal of Experimental Medicine, 2002
To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues.
L. Bonifaz, D. Bonnyay, K. Mahnke, M. Rivera, M. Nussenzweig, R. Steinman   +5 more
semanticscholar   +1 more source

Evolution of major histocompatibility complex gene copy number.

PLoS Computational Biology, 2019
MHC genes, which code for proteins responsible for presenting pathogen-derived antigens to the host immune system, show remarkable copy-number variation both between and within species.
Piotr Bentkowski, Jacek Radwan
doaj   +1 more source

The Marine Mammal Class II Major Histocompatibility Complex Organization

Frontiers in Immunology, 2019
Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system ...
André Luiz Alves de Sá, André Luiz Alves de Sá, Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz Schneider   +7 more
doaj   +1 more source

THE MAJOR HISTOCOMPATIBILITY COMPLEX OF THE RAT1

Transplantation, 1987
Thomas J. Gill, Heinz W. Kunz, Dhirendra N. Misra, Andrea L. Cortese Hassett   +3 more
openalex   +3 more sources

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Nature Communications, 2015
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive.
A. Cortes, S. Pulit, P. Leo, J. J. Pointon, P. Robinson, M. Weisman, Michael D. Ward, L. Gensler, Xiaodong Zhou, H. Garchon, G. Chiocchia, J. Nossent, B. Lie, Ø. Førre, J. Tuomilehto, K. Laiho, L. Bradbury, D. Elewaut, R. Burgos-Vargas, S. Stebbings, L. Appleton, C. Farrah, Jonathan Lau, N. Haroon, J. Mulero, F. Blanco, M. González-Gay, C. López-Larrea, P. Bowness, K. Gaffney, H. Gaston, D. Gladman, P. Rahman, W. Maksymowych, J. Crusius, I. E. van der Horst-Bruinsma, R. Valle-Oñate, C. Romero-Sánchez, I. M. Hansen, F. Pimentel-Santos, R. Inman, Javier Martín, M. Breban, Bryan Paul Wordsworth, J. Reveille, David M. Evans, P. D. de Bakker, M. Brown   +47 more
semanticscholar   +1 more source

Major Histocompatibility Complex (MHC) Markers in Conservation Biology [PDF]

, 2011
Human impacts through habitat destruction, introduction of invasive species and climate change are increasing the number of species threatened with extinction.
Acevedo-Whitehouse, Aguado, Aguilar, Aguilar, Alcaide, Alcaide, Alcaide, Aldridge, Archie, Babik, Babik, Beata Ujvari, Becker, Belov, Benacerraf, Bentley, Bernatchez, Blankenburg, Blumberg, Bollmer, Bouzat, Bowen, Bowen, Brindley, Browning, Clark, Cresswell, Cresswell, Dausset, De Groot, Doherty, Doherty, Drake, Edmands, Edwards, Eizaguirre, Ekblom, Ellegren, Evans, Fabrizio, Fernandez De Mera, Frankham, Frankham, Frankham, Frankham, Frankham, Frankham, Frankham, Frankham, Froeschke, Gilpin, Glatston, Glatston, Glatston, Go, Goda, Gomez-Mestre, Gorer, Gutierrez-Espleta, Hansen, Harf, Hedrick, Hedrick, Hedrick, Hedrick, Hedrick, Hedrick, Hedrick, Hedrick, Hedrick, Hughes, Huisinga, Kalbe, Kanthaswamy, Katherine Belov, Keller, Kelley, Kennedy, Kennedy, Kloch, Kohn, Kurbel, Land, Lekutis, Li, Lindblad-Toh, Luikart, Lynch, Madsen, Madsen, Madsen, Madsen, Madsen, Marsden, Mason, McAloose, McCallum, McKay, Mikko, Mikko, Milinski, Miller, Miller, Miller, Miller, Murgia, Olsson, Oosterhout, Ouborg, O’Brien, O’Brien, O’Brien, O’Brien, Palo, Paterson, Penn, Penn, Peters, Pfrender, Piertney, Pokorny, Potts, Radwan, Reed, Richardson, Richmond, Rietkerk, Saccheri, Salas, Schad, Schad, Schwensow, Seddon, Seddon, Shendure, Siddle, Siddle, Siddle, Slate, Smith, Smulders, Snell, Sommer, Sommer, Sommer, Spurgin, Stuglik, Tallmon, Thomas, Townsend, Trau, Ujvari, Ujvari, Vilà, Vrijenhoek, Wan, Weber, Wedekind, Wegner, Westemeier, Willi, Yang, Zagalska-Neubauer, Zhang, Zhu   +164 more
core   +3 more sources

Major histocompatibility complex and its importance towards controlling infection

Asian Journal of Medical Sciences, 2017
It is well documented that infectious pathogen burden and infected cell mass determine the clinical severity of infectious diseases, however, the ability of the host to recognize and process antigens to produce antibodies or the cellular immune response ...
Langamba Angom Longjam
doaj   +1 more source