Results 61 to 70 of about 991,100 (420)

Peptide Immunization Indicates that CD8+ T Cells are the Dominant Effector Cells in Trinitrophenyl-Specific Contact Hypersensitivity [PDF]

, 2000
The identity of the effector T cell population involved in contact hypersensitivity is still questionable with evidence promoting both CD4+ or CD8+ T cells.
Delattre, Virginie, Kohler, Jochen, Lappin, Michael B., Leicht, Cornelia, Martin, Stefan, Preckel, Tobias, Simon, Jan C., Weltzien, Hans Ulrich   +7 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

HLA-check: evaluating HLA data from SNP information

BMC Bioinformatics, 2017
Background The major histocompatibility complex (MHC) region of the human genome, and specifically the human leukocyte antigen (HLA) genes, play a major role in numerous human diseases.
Marc Jeanmougin, Josselin Noirel, Cédric Coulonges, Jean-François Zagury   +3 more
doaj   +1 more source

PCR-based isolation of multigene families: Lessons from the avian MHC class IIB [PDF]

, 2013
The amount of sequence data available today highly facilitates the access to genes from many gene families. Universal primers amplifying the desired genes over a range of species are readily obtained by aligning conserved gene regions, and laborious gene isolation procedures can often be replaced by quicker PCR-based approaches.
arxiv   +1 more source

What cleaves? Is proteasomal cleavage prediction reaching a ceiling? [PDF]

arXiv, 2022
Epitope vaccines are a promising direction to enable precision treatment for cancer, autoimmune diseases, and allergies. Effectively designing such vaccines requires accurate prediction of proteasomal cleavage in order to ensure that the epitopes in the vaccine are presented to T cells by the major histocompatibility complex (MHC).
arxiv  

Major Histocompatibility Complex and Cell Cooperation [PDF]

, 2017
We have studied the role of major histocompatibility antigens on cell cooperation in the immune response of the chicken. In the 1970's, shortly after the initial discoveries in the mouse, we demonstrated that the T cell-B cell interaction is major ...
TOIVANEN, AULI, TOIVANEN, PAAVO, VAINIO, OLLI   +2 more
core  

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

On the Border of the Amyloidogenic Sequences: Prefix Analysis of the Parallel Beta Sheets in the PDB\_Amyloid Collection [PDF]

arXiv, 2020
The Protein Data Bank (PDB) today contains more than 153,000 entries with the 3-dimensional structures of biological macromolecules. Using the rich resources of this repository, it is possible identifying subsets with specific, interesting properties for different applications.
arxiv  

PeptX: Using Genetic Algorithms to optimize peptides for MHC binding [PDF]

, 2011
Background The binding between the major histocompatibility complex and the presented peptide is an indispensable prerequisite for the adaptive immune response.
A Logean, AS Parker, AW Purcell, B Knapp, B Knapp, B Knapp, B Knapp, B Peters, Bernhard Knapp, C Lundegaard, D Rognan, DH Ackley, DR Flower, EM Lafuente, F Sieker, GA Lazar, GE Crooks, H Tsurui, HG Rammensee, HH Lin, HH Lin, I Dimitrov, IA Doytchinova, J Alexander, J Alexander, J Wan, J Xu, JC Tong, JC Tong, JE Baker, JH Holland, JM Wisniewska, K Falk, K Roomp, M Bhasin, M Larche, M Larche, M Larche, MG Rudolph, MN Davies, MN Davies, NC Toussaint, O Schueler-Furman, P Donnes, P Guan, P Saxova, P Wang, PA Reche, Q Zhang, R Vita, R Wang, Reiner Ribarics, S Mishra, T Baeck, U Gowthaman, VA Walshe, Verena Giczi, Wolfgang Schreiner, X Shang, Y El-Manzalawy   +59 more
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source