Results 61 to 70 of about 242,210 (352)

Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO [PDF]

, 2000
Antigen presentation by major histocompatibility complex class II molecules is essential for antibody production and T cell activation. For most class II alleles, peptide binding depends on the catalytic action of human histocompatibility leukocyte ...
Adams, Avva, Bakke, Bowman, Denzin, Denzin, Denzin, Escola, Fernandez-Borja, Fling, Fremont, Geluk, Ghosh, Griffin, Heim, Karas, Kropshofer, Kropshofer, Lampson, Lanzavecchia, Liljedahl, Liljedahl, Lindner, Malcherek, Martin, Mellins, Mitchell, Miyazaki, Morris, Morton, Mosyak, Pieters, Pinet, Pinet, Pious, Roche, Sambrook, Sanderson, Sanderson, Sherman, Siemasko, Sloan, Tonnelle, van Ham, van Ham, Vestal, Weber, Young   +47 more
core   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species

mBio, 2017
Development of a vaccine to protect against cryptococcosis is a priority given the enormous global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery system, we previously demonstrated that mice vaccinated with crude ...
Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Jennifer K. Lodge, Ali Akalin, Jane Homan, Gary R. Ostroff, Stuart M. Levitz   +15 more
doaj   +1 more source

454 screening of individual MHC variation in an endemic island passerine [PDF]

, 2014
Genes of the major histocompatibility complex (MHC) code for receptors that are central to the adaptive immune response of vertebrates. These genes are therefore important genetic markers with which to study adaptive genetic variation in the wild.
Gonzalez Quevedo, Catalina, Phillips, Karl, Richardson, David, Spurgin, Lewis   +3 more
core   +2 more sources

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Characterization of the bovine major histocompatibility complex [PDF]

, 2013
Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the ...
McArthur, Monica
core   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Andrews, TD, Beck, S, Berlin, K, Cox, AV, Fischer, J, Gut, IG, Hildmann, T, Howe, KL, Lewin, J, Novik, KL, Olek, A, Otto, T, Rakyan, VK, Tost, J   +13 more
core  

Pretransplant HLA typing revealed loss of heterozygosity in the major histocompatibility complex in a patient with acute myeloid leukemia [PDF]

, 2019
Introduction Chromosomal abnormalities are frequent events in hematological malignancies. The degree of HLA compatibility between donor and recipient in hematopoietic stem cell transplantation is critical.
Breman, Amy M., Britton, Rebecca M., Cui, Connie P., Farag, Sherif S., Kashi, Zahra, Krueger-Sersen, Mary, Littrell, Courtney A., Lobashevsky, Andrew L., Martin, Russ K., Singh, Susmita, Vance, Gail H.   +10 more
core   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source