Results 11 to 20 of about 2,057 (163)

Structural Alterations Associated With Cardiovascular Autonomic Failure in Multiple System Atrophy. [PDF]

Eur J Neurol
ABSTRACT Background Early severe autonomic failure (AF) in multiple system atrophy (MSA) is a risk factor for poor survival. Postmortem studies suggested that AF is related to the degeneration of preganglionic autonomic neurons of the brainstem and spinal cord. Objectives Characterize cerebral alterations on brain imaging associated with cardiovascular
Georges C, Arribarat G, Kermorgant M, Bonneville F, Fabbri M, Foubert A, Meissner W, Rascol O, Traon AP, Péran P.   +9 more
europepmc   +2 more sources

Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment

BMC Biology, 2023
Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis. While P2Y12-R
Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés, Véronique Pons   +8 more
doaj   +1 more source

Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex

Cells, 2023
In humans and animal models, intermittent fasting (IF) interventions promote body weight loss, improve metabolic health, and are thought to lower cardiovascular disease risk.
Jules Mérian, Lamia Ghezali, Charlotte Trenteseaux, Thibaut Duparc, Diane Beuzelin, Vanessa Bouguetoch, Guillaume Combes, Nabil Sioufi, Laurent O. Martinez, Souad Najib   +9 more
doaj   +1 more source

Ibrutinib does not prevent kidney fibrosis following acute and chronic injury

Scientific Reports, 2021
Recent studies suggested that ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, developed for the treatment of chronic lymphocytic leukemia, may prevent NLRP3 inflammasome activation in macrophages, IL-1β secretion and subsequent development of ...
Julie Belliere, Audrey Casemayou, Eloïse Colliou, Hélène El Hachem, Clément Kounde, Alexis Piedrafita, Guylène Feuillet, Joost P. Schanstra, Stanislas Faguer   +8 more
doaj   +1 more source

Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests

eLife, 2023
The rod-shaped adult cardiomyocyte (CM) harbors a unique architecture of its lateral surface with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) with unknown role.
Clement Karsenty, Celine Guilbeau-Frugier, Gaël Genet, Marie-Helene Seguelas, Philippe Alzieu, Olivier Cazorla, Alexandra Montagner, Yuna Blum, Caroline Dubroca, Julile Maupoint, Blandine Tramunt, Marie Cauquil, Thierry Sulpice, Sylvain Richard, Silvia Arcucci, Remy Flores-Flores, Nicolas Pataluch, Romain Montoriol, Pierre Sicard, Antoine Deney, Thierry Couffinhal, Jean-Michel Senard, Celine Galés   +22 more
doaj   +1 more source

Obésité et maladies cardiovasculaires [PDF]

médecine/sciences, 2003
Available evidence clearly indicates a rapid progression in the prevalence of obesity worldwide. As a consequence, there has also been a marked increase in the prevalence of type 2 diabetes all over the world and this chronic metabolic disease is now considered as a coronary heart disease risk equivalent.
Poirier, Paul, Després, Jean-Pierre
openaire   +2 more sources

Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias

Cells, 2021
Both inherited and acquired cardiac arrhythmias are often associated with the abnormal functional expression of ion channels at the cellular level. The complex machinery that continuously traffics, anchors, organizes, and recycles ion channels at the ...
Camille E. Blandin, Basile J. Gravez, Stéphane N. Hatem, Elise Balse   +3 more
doaj   +1 more source

Diuretic dose is a strong prognostic factor in ambulatory patients awaiting heart transplantation

ESC Heart Failure, Volume 10, Issue 5, Page 2843-2852, October 2023., 2023
Abstract Aims The prognostic value of ‘high dose’ loop diuretics in advanced heart failure outpatients is unclear. We aimed to assess the prognosis associated with loop diuretic dose in ambulatory patients awaiting heart transplantation (HT). Methods and results All ambulatory patients (n = 700, median age 55 years and 70% men) registered on the French
Guillaume Baudry, Guillaume Coutance, Richard Dorent, Fabrice Bauer, Katrien Blanchart, Aude Boignard, Céline Chabanne, Clément Delmas, Nicolas D'Ostrevy, Eric Epailly, Vlad Gariboldi, Philippe Gaudard, Céline Goéminne, Sandrine Grosjean, Julien Guihaire, Romain Guillemain, Mathieu Mattei, Karine Nubret, Sabine Pattier, Emmanuelle Vermes, Laurent Sebbag, Kevin Duarte, Nicolas Girerd, Marie‐France Seronde, Pauline Fournier, Caroline Augier   +25 more
wiley   +1 more source

The Sexual Dimorphism of Human Adipose Depots

Biomedicines, 2022
The amount and the distribution of body fat exhibit trajectories that are sex- and human species-specific and both are determinants for health. The enhanced accumulation of fat in the truncal part of the body as a risk factor for cardiovascular and ...
Nathalie Boulet, Anais Briot, Jean Galitzky, Anne Bouloumié   +3 more
doaj   +1 more source

Antithrombotic Treatment in Patients With Hemophilia: an EHA‐ISTH‐EAHAD‐ESO Clinical Practice Guidance

HemaSphere, Volume 7, Issue 6, June 2023., 2023
Cardiovascular disease is an emerging medical issue in patients with hemophilia (PWH) and its prevalence is increasing up to 15% in PWH in the United States. Atrial fibrillation, acute and chronic coronary syndromes, venous thromboembolism, and cerebral thrombosis are frequent thrombotic or prothrombotic situations, which require a careful approach to ...
Roger E.G. Schutgens, Victor Jimenez‐Yuste, Miguel Escobar, Anna Falanga, Bruna Gigante, Robert Klamroth, Riitta Lassila, Frank W.G. Leebeek, Michael Makris, Tarek Owaidah, Michelle Sholzberg, Andreas Tiede, David J. Werring, H. Bart van der Worp, Jerzy Windyga, Giancarlo Castaman   +15 more
wiley   +1 more source