Results 91 to 100 of about 93,889 (197)

Application of Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging in Food Authenticity Assessment and Variety Identification [PDF]

Shipin Kexue
Food authenticity assessment and variety identification are crucial for ensuring food safety and protecting consumer rights. Traditional analytical techniques provide qualitative and quantitative information on target compounds, forming an essential ...
SHAO Zhenchao, PANG Bo, REN Yulong, DI Shuangshuang, LIAN Jie, NIE Honggang
doaj   +1 more source

A guide to laser microdissection‐based proteomics

The FEBS Journal, Volume 293, Issue 21, Page 6308-6318, November 2026.
This review takes researchers through the full laser microdissection proteomics workflow—from tissue preparation and image analysis to sample processing and mass spectrometry—offering practical solutions to common challenges at each step. Real‐world examples from across the field illustrate how the technology is being applied to disease tissue, making ...
Cheng Shen, Kael Schoffer, Charlotte Williams, Maria C. Tanzer   +3 more
wiley   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, Volume 179, Issue 3, Page 418-433, November 2026.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant

, 2017
Study of skin penetration and distribution of the drug compounds in the skin is a major challenge in the development of topical drug products for treatment of skin diseases.
Janfelt, Christian, Nina Ø. Knudsen, Eriksson, André H, Christian Janfelt, Anders J. Pedersen, Knudsen, Nina Ø, Isabella S. Sørensen, Nielsen, Mette Marie B, Mortensen, Rasmus W, Mette Marie B. Nielsen, Nielsen, Kim T, Kim T. Nielsen, André H. Eriksson, Rasmus W. Mortensen, Sørensen, Isabella S, Pedersen, Anders J   +15 more
core   +1 more source

Site-to-Site Reproducibility and Spatial Resolution in MALDI-MSI of Peptides from Formalin-Fixed Paraffin-Embedded Samples.

, 2019
To facilitate the transition of MALDI-MS Imaging (MALDI-MSI) from basic science to clinical application, it is necessary to analyze formalin-fixed paraffin-embedded (FFPE) tissues.
Ly, Alice;Longuespée, Rémi;Casadonte, Rita;Wandernoth, Petra;Schwamborn, Kristina;Bollwein, Christine;Marsching, Christian;Kriegsmann, Katharina;Hopf, Carsten;Weichert, Wilko;Kriegsmann, Jörg;Schirmacher, Peter;Kriegsmann, Mark;Deininger, Sören-Oliver
core   +1 more source

Innovations in MALDI MSI

This thesis focuses on the development of instruments and methods to improve mass spectrometry imaging (MSI). MSI enables simultaneous detection and localization of molecules in samples such as tissues or single cells. The ion source presented in this thesis improves spatial resolution in MSI experiments, enabling smaller pixel sizes. Coupling the mass
openaire   +2 more sources

Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination with machine learning

Scientific Reports
Cutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and do not provide metabolomic insight.
Lauritz F. Brorsen, James S. McKenzie, Mette F. Tullin, Katja M. S. Bendtsen, Fernanda E. Pinto, Henrik E. Jensen, Merete Haedersdal, Zoltan Takats, Christian Janfelt, Catharina M. Lerche   +9 more
doaj   +1 more source

Development of matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) for plant metabolite analysis [PDF]

, 2015
This thesis presents efforts to improve the methodology of matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) as a method for analysis of metabolites from plant tissue samples.
Korte, Andrew
core   +1 more source

Examining Plasma Polymer‐Coated Indium Tin Oxide Slides to Enhance Analyte Detection in Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Chemistry–Methods
Analyte delocalization is a significant challenge in matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI). In this study, we present a novel approach to decrease this phenomenon and improve analyte detection by modifying ...
Parul Mittal, Iliana Delcheva, Jens Soltwisch, Peter Hoffmann, Melanie MacGregor, Manuela Klingler‐Hoffmann   +5 more
doaj   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances
Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues.
Toufik Mahamdi, Oscar Yanes
doaj   +1 more source