Results 81 to 90 of about 93,889 (197)
Chemical mapping of the colorectal cancer microenvironment via MALDI imaging mass spectrometry (MALDI-MSI) reveals novel cancer-associated field effects [PDF]
, 2013 Matrix‐assisted laser desorption ionisation imaging mass spectrometry (MALDI‐MSI) is a rapidly advancing technique for intact tissue analysis that allows simultaneous localisation and quantification of biomolecules in different histological regions of ...
Vorkas, PA +12 more
core +1 more source
Mass Spectrometry Imaging–Guided Proteomics, an Emerging Frontier in Spatial Biology
Mass Spectrometry Reviews, EarlyView.ABSTRACT Spatial heterogeneity is a defining feature of tissue organization, yet conventional proteomic analysis provides limited information about the spatial origins of identified proteins. Spatially guided proteomics addresses this limitation by using tissue imaging techniques to select regions of interest (ROIs) for localized analysis by liquid ...
Kenneth Weke +4 more
wiley +1 more source
, 2018 Immunotherapies are treatments that use a patient’s immune system to combat disease. One important type of immunotherapy employed in cancer treatments is the delivery of monoclonal antibodies to block growth receptors.
Amanda B. Hummon (1342524) +13 more
core +1 more source
Metabolites, 2014 Understanding the spatial distribution of bioactive small molecules is indispensable for elucidating their biological or pharmaceutical roles. Mass spectrometry imaging (MSI) enables determination of the distribution of ionizable molecules present in ...
Yoshinori Fujimura, Daisuke Miura
doaj +1 more source
Phytotherapy Research, EarlyView.Amomum villosum essential oil (AVEO) alleviates LPS‐induced neuroinflammation and cognitive and behavioral dysfunction by suppressing PI3K‐Akt and MAPK signaling pathways, modulating inflammatory responses, and restoring metabolic homeostasis, thereby exerting neuroprotective effects. ABSTRACT Amomum villosum Lour.
Hongjin Wang +11 more
wiley +1 more source
MALDI MSI for a fresh view on atherosclerotic plaque lipids [PDF]
Pflügers Archiv - European Journal of Physiology, 2021 Worthmann, Anna, Bartelt, Alexander
openaire +4 more sources
Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors
International Journal of Cancer, Volume 159, Issue 12, Page 3038-3048, 15 December 2026.ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan +6 more
wiley +1 more source
MALDI-MSI Analysis of Cytological Smears: The Study of Thyroid Cancer
, 2017 Fine needle aspiration (FNA) biopsies are the current gold-standard for the preoperative evaluation of thyroid nodules. However, a significant number of them (15-30%) are unable to be affirmatively diagnosed and are given an "indeterminate for malignancy" final report, meaning that the malignant nature of the thyroid nodule remains unknown and the ...
Mosele, N +4 more
openaire +2 more sources
Tumor classification with MALDI-MSI data of tissue microarrays: A case study
Methods, 2018 With mass spectrometry imaging (MSI) on tissue microarrays (TMAs) a large number of biomolecules can be studied for many patients at the same time, making it an attractive tool for biomarker discovery. Here we investigate whether lymph node metastasis can be predicted from MALDI-MSI data.
N.E. Mascini (Nadine) +4 more
openaire +2 more sources