Results 81 to 90 of about 221,321 (308)

Key Gene and Functional Pathways Identified in Unexplained Recurrent Spontaneous Abortion Using Targeted RNA Sequencing and Clinical Analysis

Frontiers in Immunology, 2021
Identifying the mechanisms underlying unexplained recurrent spontaneous abortion (URSA) can help develop effective treatments. This study provides novel insights into the biological characteristics and related pathways of differentially expressed genes ...
Heng Gu, Longyu Li, Mengxuan Du, Mengxuan Du, Hang Xu, Hang Xu, Mengge Gao, Mengge Gao, Xiaohua Liu, Xiangcai Wei, Xiangcai Wei, Xingming Zhong, Xingming Zhong   +12 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The wild male mink as a sentinel for endocrine-disrupting chemicals and reproductive toxicity [PDF]

, 2013
Increasing evidence indicates that pollutants may affect the hormone system of humans and wildlife. These endocrine-disrupting chemicals are related to an increased risk of a variety of diseases and disorders, including adverse effects on the ...
Persson, Sara
core  

Studies of male reproduction in the Greater Bilby Macrotis lagotis

, 2010
Despite its vulnerable conservation status there is scant information on male Greater Bilby Macrotis lagotis reproduction. Observations of gross anatomy revealed a testis to body weight ratio of 0.08 - 0.17% (n = 4), the presence of a carrot shaped ...
Nicolson, V., Keeley, T., Keeley, Tamara, Stenzel, D., Blyde, D., Stenzel, Deborah, Nicholson, Vere, Rumph, C., Johnston, Steve, Lucht, M., Johnston, S. D.   +10 more
core   +1 more source

Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the age

Frontiers in Endocrinology, 2023
BackgroundKlinefelter’s syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this.
Huang Liu, Zhenhui Zhang, Yong Gao, Hai Lin, Zhiyong Zhu, Houbin Zheng, Wenjing Ye, Zefang Luo, Zhaohui Qing, Xiaolan Xiao, Lei Hu, Yu Zhou, Xinzong Zhang   +12 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Depigmented wing patch size is a condition-dependent indicator of viability in male collared flycatchers

, 2003
Honesty of sexual advertisement is thought to be the result of signalling costs. Because production costs of depigmented plumage patches are probably very low, their role as honest signals of individual quality has been questioned. Costs of bearing these
Hegyi, Gergely, T\uf6r\uf6k, Janos, Török, János, Garamszegi, L\ue1szl\uf3, Garamszegi, László Zsolt   +4 more
core   +1 more source

Heat Stress as a Barrier to Successful Reproduction and Potential Alleviation Strategies in Cattle

, 2023
In recent decades, the adverse effects of global warming on all living beings have been unanimously recognized across the world. A high environmental temperature that increases the respiration and rectal temperature of cattle is called heat stress (HS ...
Il-Keun Kong, Yun Seok Heo, Seo-Hyun Lee, Ghulam Nabi, Ayman Mesalam, Imran Khan   +5 more
core   +1 more source

EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner

Endocrine Connections, 2017
Human sperm cell function must be precisely regulated to achieve natural fertilization. Progesterone released by the cumulus cells surrounding the egg induces a Ca2+ influx into human sperm cells via the CatSper Ca2+-channel and thereby controls sperm ...
A Rehfeld, D L Egeberg, K Almstrup, J H Petersen, S Dissing, N E Skakkebæk   +5 more
doaj   +1 more source