Results 61 to 70 of about 1,065,944 (354)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Association between single nucleotide polymorphisms, TGF-β1 promoter methylation, and polycystic ovary syndrome

BMC Pregnancy and Childbirth
Background Polycystic ovarian syndrome (PCOS) is a common endocrine and metabolic disease in women. Hyperandrogenaemia (HA) and insulin resistance (IR) are the basic pathophysiological characteristics of PCOS.
Mengge Gao, Xiaohua Liu, Heng Gu, Hang Xu, Wenyao Zhong, Xiangcai Wei, Xingming Zhong   +6 more
doaj   +1 more source

Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid

Environment International, 2022
Objective: To examine whether selected endocrine disrupting chemicals were present in pregnant women and passed through the placental barrier to amniotic fluid, potentially exposing the developing fetus.
Elvira V. Bräuner, Cecilie S. Uldbjerg, Youn-Hee Lim, Laura S. Gregersen, Marianna Krause, Hanne Frederiksen, Anna-Maria Andersson   +6 more
doaj   +1 more source

Estrogens and male reproduction [PDF]

, 2016
n males, estrogens exert pleiotropic effects by acting on several tissue and organs, including the male reproductive system. The action of estrogens is manifest from prenatal life during which the exposure to estrogen excess might influence the ...
Carani, Cesare, Diazzi, Chiara, Madeo, Bruno, Rochira, Vincenzo, Santi, Daniele, Zirilli, Lucia   +5 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Deletion in the uridine diphosphate glucuronyltransferase 2B17 gene is associated with delayed pubarche in healthy boys

Endocrine Connections, 2018
Objective: Only a few genetic loci are known to be associated with male pubertal events. The ability of excreting testosterone (T) and other steroids in the urine depends on sulfation and glucuronidation.
Annette Mouritsen, Alexander Siegfried Busch, Lise Aksglaede, Ewa Rajpert-De Meyts, Anders Juul   +4 more
doaj   +1 more source

The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]

, 1989
Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F., Bannister P., Bardin C. W., Booth A. N., Cardon S. B., Chamness G. C., D. H. Van Thiel, D. Kahn, Eagon P. K., Eisenfeld A. J., Farrell G. C., Francavilla A., Francavilla A., Gustafsson J. A., H. Lai, Higgins E. M., L. Makowka, Lowry O. H., M. Kajani, P. K. Eagon, Q. Zeng, Starzl T. E., T. E. Starzl, Van DH Thiel, Van DH Thiel   +24 more
core   +1 more source

Annual variation in the levels of transcripts of sex-specific genes in the mantle of the common mussel, Mytilus edulis [PDF]

, 2012
Mytilus species are used as sentinels for the assessment of environmental health but sex or stage in the reproduction cycle is rarely considered even though both parameters are likely to influence responses to pollution.
A Gorbman, A Hines, A Hines, A Scarpato, A Tanguy, A Viarengo, A Wacker, AM Debruyn, B Gaylord, BE Galindo, CM Ciocan, CM Ciocan, CM Ciocan, D de Longcamp, D Fernandes, D Le Guellec, DE Morse, DJ Waxman, DR Livingstone, ED Goldberg, F Gazeau, GG Lauenstein, GN Eick, HG Choi, I Zorita, J Burger, Jack Anthony Gilbert, JF Narbonne, John A. Craft, K Inoue, K Ramu, KC Srivastava, KJ Livak, M Banni, M Banni, M Brown, M Ortiz-Zarragoitia, M Osada, M Shoji, M Torrado, MF Martinez, MH Devier, PP Fong, PP Fong, PS York, R Barra, R Lazzara, RT Counihan, S Carreau, S Fasulo, Sandhya Anantharaman, SF Cummins, SP Boyle, T Matsutani, T Onitsuka, T Takagi, T Tanabe, VD Vacquier, W Sedik   +58 more
core   +7 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Advances in Contraceptive Vaccine Development: A Comprehensive Review

Vaccines
The issues of uncontrolled global population growth and unintended pregnancies are severe, and the existing contraceptive methods have numerous limitations, making the development of novel contraceptive technologies urgent. Contraceptive vaccines offer a
Wen Gao, Xiaoting Shen, Peipei Li, Chanchan Xiao, Yongxia Wang   +4 more
doaj   +1 more source