Results 71 to 80 of about 1,065,944 (354)

High Throughput scRNA-Seq Provides Insights Into Leydig Cell Senescence Induced by Experimental Autoimmune Orchitis: A Prominent Role of Interstitial Fibrosis and Complement Activation

Frontiers in Immunology, 2022
Leydig cells (Lc), located in the interstitial space of the testis between seminiferous tubules, produce 95% of testosterone in male individuals, which is pivotal for male sexual differentiation, spermatogenesis, and maintenance of the male secondary sex
Yinchuan Li, Yinchuan Li, Panpan Mi, Jiabao Wu, Yunge Tang, Xiaohua Liu, Jinmei Cheng, Yingying Huang, Weibing Qin, C. Yan Cheng, Fei Sun   +10 more
doaj   +1 more source

Paternal effects correlate with female reproductive stimulation in the polyandrous ladybird Cheilomenes sexmaculata [PDF]

, 2014
Citation: Mirhosseini, M., Michaud, J., Jalali, M., & Ziaaddini, M. (2014). Paternal effects correlate with female reproductive stimulation in the polyandrous ladybird Cheilomenes sexmaculata. Bulletin of Entomological Research, 104(4), 480-485. https:
Jalali, M. A., Michaud, J. P., Mirhosseini, M. A., Ziaaddini, M.   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila [PDF]

, 2012
Conclusions: Our study presents evidence that Est-6 plays a role in the physiological and behavioral dynamics of sex pheromone response in Drosophila males and supports a role of Est-6 as an odorant-degrading enzyme (ODE) in male antennae.
Chertemps, Thomas, Dekker, Teun, Durand, Nicolas, Francois, Adrien, Lucas, Philippe, Maibeche-Coisne, Martine, Rosell, Gloria   +6 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Key Gene and Functional Pathways Identified in Unexplained Recurrent Spontaneous Abortion Using Targeted RNA Sequencing and Clinical Analysis

Frontiers in Immunology, 2021
Identifying the mechanisms underlying unexplained recurrent spontaneous abortion (URSA) can help develop effective treatments. This study provides novel insights into the biological characteristics and related pathways of differentially expressed genes ...
Heng Gu, Longyu Li, Mengxuan Du, Mengxuan Du, Hang Xu, Hang Xu, Mengge Gao, Mengge Gao, Xiaohua Liu, Xiangcai Wei, Xiangcai Wei, Xingming Zhong, Xingming Zhong   +12 more
doaj   +1 more source

Movement ecology and sex are linked to barn owl microbial community composition. [PDF]

, 2020
The behavioural ecology of host species is likely to affect their microbial communities, because host sex, diet, physiology, and movement behaviour could all potentially influence their microbiota.
Bowie, Rauri CK, Charter, Motti, Corl, Ammon, Getz, Wayne M, Kamath, Pauline L, Nathan, Ran, Rozman, Gabe, Toledo, Sivan, Turjeman, Sondra   +8 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the age

Frontiers in Endocrinology, 2023
BackgroundKlinefelter’s syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this.
Huang Liu, Zhenhui Zhang, Yong Gao, Hai Lin, Zhiyong Zhu, Houbin Zheng, Wenjing Ye, Zefang Luo, Zhaohui Qing, Xiaolan Xiao, Lei Hu, Yu Zhou, Xinzong Zhang   +12 more
doaj   +1 more source

Cichlids do not adjust reproductive skew to the availability of independent breeding options [PDF]

, 2017
Helpers in cooperatively breeding species forego all or part of their reproduction when remaining at home and assisting breeders to raise offspring. Different models of reproductive skew generate alternative predictions about the share of reproduction ...
Bachar, Zina, Bergmüller, Ralph, Bonfils, Danielle, Burri, Reto, Heckel, Gerald, Heg, Dik, Otti, Oliver, Taborsky, Michael   +7 more
core