Results 71 to 80 of about 221,321 (308)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Male-killing bacteria in insects: mechanisms, incidence and implications

, 2000
Bacteria that are vertically transmitted through female hosts and kill male hosts that inherit them were first recorded in insects during the 1950s. Recent studies have shown these "male-killers" to be diverse and have led to a reappraisal of the biology
Hurst, GDD, Jiggins, FM, Gregory D.D. Hurst, Francis M. Jiggins   +3 more
core   +1 more source

Do female association preferences predict the likelihood of reproduction? [PDF]

, 2010
Sexual selection acting on male traits through female mate choice is commonly inferred from female association preferences in dichotomous mate choice experiments.
Metcalfe, N.B., Lindstrom, J., Walling, C.A., Royle, N.J.   +3 more
core   +1 more source

Advances in Contraceptive Vaccine Development: A Comprehensive Review

Vaccines
The issues of uncontrolled global population growth and unintended pregnancies are severe, and the existing contraceptive methods have numerous limitations, making the development of novel contraceptive technologies urgent. Contraceptive vaccines offer a
Wen Gao, Xiaoting Shen, Peipei Li, Chanchan Xiao, Yongxia Wang   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A life history perspective on strategic mating effort in male scorpionflies

, 2002
Engqvist L, Sauer KP. A life history perspective on strategic mating effort in male scorpionflies. Behavioral Ecology. 2002;13(5):632-636.In species with high male mating effort, there is a trade-off between mating effort spent in a current mating and ...
Sauer, Klaus Peter, Engqvist, Leif ; https://orcid.org/   +1 more
core   +1 more source

Butterfly fitness under changing food qualities [PDF]

, 2014
The present thesis investigates how different food qualities over the whole life cycle and across generations affect butterfly development and reproduction, and addresses the following main questions: (1) What effects have varying nitrogen ...
Cahenzli, Fabian
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Estrogens and male reproduction

, 2009
The chapter deals with the study of estrogen role in male reproduction, in particulare the role on hypothalamic-pituitary-gonadal ...
ZIRILLI, Lucia, Matteo Fabbi, ROCHIRA, Vincenzo, Elena Valassi, Bruno Madeo, Vincenzo Rochira, Cesare Carani, MADEO, Bruno, CARANI, Cesare   +8 more
core   +1 more source

Estrogens, Male Reproduction and Beyond [PDF]

, 2023
In males, estrogens exert pleiotropic effects by acting on several tissue and organs, including the male reproductive system. The action of estrogens is manifest from prenatal life during which the exposure to estrogen excess might influence the ...
V. Rochira, C. Carani
core