Results 111 to 120 of about 39,650 (248)
, 2015 The Diels-Alder reaction between furan and maleimide moieties is a well-known and widely used strategy to build bio-based macromolecular structures with peculiar properties.
GIOIA, CLAUDIO +11 more
core +1 more source
Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly
Bulletin of the Korean Chemical Society, EarlyView.Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim +7 more
wiley +1 more source
Crosslinked polyimides prepared from N-(3-ethynylphenyl)maleimide [PDF]
, 1993 The compound N-(3-ethynylphenyl)maleimide (NEPMI) was used to prepare thermally stable, glassy polyimides which did not exhibit glass transition temperatures below 500 C.
Gerber, Margaret K., St.clair, Terry L.
core
, 2016 Improved methodology to prepare maleimide-functionalized, water-soluble, small (
Pierangelo Gobbo (1443952) +1 more
core +1 more source
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Oligonucleotide cyclization: The thiol-maleimide reaction revisited
A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol ...
Grandas Sagarra, Anna +2 more
core
, 2012 Improved methodology to prepare maleimide-functionalized, water-soluble, small (
Gobbo P, Workentin MS
core +1 more source
Harnessing bacterial extracellular vesicles for bone and cartilage organoids
BMEMat, EarlyView.This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu +8 more
wiley +1 more source
BMEMat, EarlyView.A defined 700 nm low‐density nanotopographical interface mechanically primes MSCs through the integrin β1–focal adhesion–Akt–Rab27a‐dependent pathway, enhancing exosome secretion and osteoinductive potency. Enrichment of miR‐548d‐5p in these exosomes promotes osteogenic differentiation and bone regeneration, establishing nanotopography‐guided MSC ...
Ziqi Zhang +12 more
wiley +1 more source
N-(3-ethynylphenyl)maleimide [PDF]
, 1990 Acetylene terminated aspartimides are prepared using two methods. In the first, an amino-substituted aromatic acetylene is reacted with an aromatic bismaleimide in a solvent of glacial acetic acid and/or m-cresol.
Hergenrother, Paul M. +2 more
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