Results 121 to 130 of about 43,444 (345)

Degradable Alternating Copolymers With Strained Cyclobutane Backbones via Photocontrolled RAFT Polymerization

Angewandte Chemie, EarlyView.
A photocontrolled RAFT strategy enables the alternating copolymerization of 1,3‐disubstituted bicyclo[1.1.0]butanes with electron‐deficient comonomers, affording well‐defined copolymers bearing strained cyclobutane backbones. A high degree of alternation, tunable molecular weights, and excellent end‐group fidelity are achieved through a CTA‐mediated ...
Xia Hu, Hongsik Kim, Lianqian Wu, Yi Jiang, Tae‐Lim Choi   +4 more
wiley   +2 more sources

THERMALLY CLEAVABLE HYBRID MATERIALS

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
Thermally cleavable hybrid materials were prepared by the Diels-Alder cycloaddition reaction of poly(vinyl furfural) to N phenylmaleimido-N’-(triethoxysilylpropyl)urea followed by the sol-gel condensation reaction of trietoxysilyl groups with water and ...
Constantin Gaina, Oana Ursache, Viorica Gaina   +2 more
doaj  

Quantum‐Trained AI Enables Inverse Design of Organic Frontier Orbitals at Billion‐Scale

Advanced Science, EarlyView.
Quantum‐trained AI links molecular substructures to frontier‐orbital energetics and enables interpretable screening across nearly one billion GDB‐13 molecules. By combining fragment‐ and ring‐level insights with donor–acceptor energy alignment against ITIC, the framework narrows an immense chemical space to a small set of promising candidates and ...
Yeongnam Ko, Se Jin Kim, Ki Chul Kim
wiley   +1 more source

High-performance electro-optic materials featuring enhanced thermal stability through dual-donor structural crosslinking engineering. [PDF]

Smart Mol
A groundbreaking dual‐donor crosslinking strategy was reported to significantly enhance the thermal stability, achieving remarkable EO coefficients (257–301 pm/V), glass transition temperatures (Tg) ranging from 107–187°C, and ultrahigh chromophore densities (3.73–4.26 × 10²⁰ molecules/cm³) with exceptional long‐term stability after 500 h at 85°C ...
Zhang Y, Zheng Z, Huang Z, Liu Z, Chen Y, Huo F, Liu F, Xu X.   +7 more
europepmc   +2 more sources

Novel Functionalised Modifiers for Bis-Maleimide Polymers. [PDF]

, 2019
A number of functionalised cyanate esters are synthesised and characterised. These functionalised cyanate esters are investigated in resin blends with commercial bis-maleimide and cyanate ester resins in an attempt to improve the Mode I fracture ...
Stedman, J. C.
core  

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

An Enzymatic Platform for Late‐Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases

Angewandte Chemie, EarlyView.
State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson, Ulrich Kauhl, Martin R. Edelmann, Florian P. Seebeck   +3 more
wiley   +2 more sources

Radical-Mediated Degradation of Thiol-Maleimide Hydrogels [PDF]

Michael addition between thiol- and maleimide-functionalized molecules is a long-standing approach used for bioconjugation, hydrogel crosslinking, and the functionalization of other advanced materials.
Benoit, Danielle S W, Kirkpatrick, Bruce E, Fairbanks, Benjamin D, Hebner, Tayler S, Bowman, Christopher, Anseth, Kristi S   +5 more
core   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Long-Term Stabilization of Maleimide–Thiol Conjugates

, 2016
Michael-addition of a thiol to a maleimide is commonly used for bioconjugation of drugs to macromolecules. Indeed, both current FDA-approved antibody–drug conjugatesBrentuximab vedotin and Trastuzumab emtansineand one approved PEGylated conjugate ...
Gary W. Ashley (1653217), Daniel V. Santi (59082), Shaun D. Fontaine (1342392), Ralph Reid (59081), Louise Robinson (124623)   +4 more
core   +1 more source