Malonates in Cyclocondensation Reactions [PDF]
Molecules, 2001 The use of malonates such as diethyl malonates 9, (chlorocarbonyl)ketenes 15 and bis(2,4,6-trichlorophenyl) malonates 18 as reagents for cyclocondensation with 1,3-dinucleophiles to give six-membered heterocycles is described.
Thomas Kappe +4 more
exaly +5 more sources
Synthesis of chiral malonates by α-alkylation of 2,2-diphenylethyl tert-butyl malonates via enantioselective phase-transfer catalysis [PDF]
Frontiers in Chemistry, 2023 An efficient synthetic approach for chiral malonates was established via enantioselective phase transfer catalysis. The α-alkylation of 2,2-diphenylethyl tert-butyl α-methylmalonates with (S,S)-3,4,5-trifluorophenyl-NAS bromide as a phase-transfer ...
Zhibin Guo +5 more
doaj +2 more sources
Dimerization/Elimination of β-Styrylmalonates under Action of TiCl4 [PDF]
Molecules, 2022 A new type of dimerization of dimethyl (β-styryl)malonates in the presence of TiCl4 accompanied by elimination of a methanol molecule was discovered.
D. D. Borisov +4 more
doaj +2 more sources
Enantioselective γ-Alkylation of α,β-Unsaturated Malonates and Ketoesters by a Sequential Ir-Catalyzed Asymmetric Allylic Alkylation/Cope Rearrangement [PDF]
Journal of the American Chemical Society, 2016 A catalytic, enantioselective γ-alkylation of α,β-unsaturated malonates and ketoesters is reported. This strategy entails a highly regio- and enantioselective iridium-catalyzed α-alkylation of an extended enolate, and a subsequent translocation of ...
Wen-bo Liu, Eric J Alexy, Allen Y Hong
exaly +6 more sources
Targeting undruggable carbohydrate recognition sites through focused fragment library design. [PDF]
Commun Chem, 2022 Carbohydrate-protein interactions are key for cell-cell and host-pathogen recognition and thus, emerged as viable therapeutic targets. However, their hydrophilic nature poses major limitations to the conventional development of drug-like inhibitors. To
Shanina E +11 more
europepmc +6 more sources
Melaminium hydrogen malonate [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 The melaminium (2,4,6-triamino-1,3,5-triazin-1-ium) cation in the title compound, C3H7N6+·C3H3O4−, is essentially planar, with a r.m.s. deviation of the non-H atoms of 0.0085 Å. Extensive hydrogen bonding of the types N—H...N and N—H...O between cations and cations and between cations and hydrogen malonate (2-carboxyethanoate) anions leads to the ...
Matthias Weil, Barbara Froschauer
openaire +4 more sources
Recent Advances in Asymmetric Organocatalyzed Conjugate Additions to Nitroalkenes [PDF]
, 2017 The asymmetric conjugate addition of carbon and heteroatom nucleophiles to nitroalkenes is a very interesting tool for the construction of highly functionalized synthetic building blocks.
Alonso, Diego A. +6 more
core +6 more sources
Molbank, 2023 This paper presents the discovery and development of antifungal agents against Fusarium oxysporum (Fox), a devastating plant pathogen. Diethyl 2-((arylamino)methylene)malonates (DAMMs) were formed as side-products during the synthesis of polysubstituted ...
Willy-Fernando Cely-Veloza +2 more
doaj +1 more source
Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A
Molecules, 2021 SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents.
Eva-Maria Dürr, Joanna F. McGouran
doaj +1 more source
Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure [PDF]
, 2011 Novel beta-aminocyclobutanecarboxylic acid derivatives were prepared via a sequential solvent-free aza-Michael addition of benzophenone imine across 3-halopropylidenemalonates and base-induced ring closure.
Aitken +44 more
core +1 more source