Results 1 to 10 of about 165,249 (191)
SIRT1 negatively regulates the mammalian target of rapamycin. [PDF]
PLoS ONE, 2010 The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+ dependent deacetylase that is known to regulate caloric restriction mediated longevity in model
Hiyaa Singhee Ghosh +2 more
doaj +4 more sources
Mammalian Target of Rapamycin in Inflammatory Skin Conditions
European Journal of Inflammation, 2014 The conserved serine/threonine kinase mammalian target of rapamycin (mTOR) is a major regulator of survival growth, proliferation and motility, in response to mitogens, energy and nutrient levels.
A. Balato +9 more
doaj +2 more sources
Recent Advances in the Development of PI3K/mTOR-Based Anticancer Agents: A Mini Review [PDF]
Folia Medica, 2021 Cancer refers to the group of diseases characterized by uncontrolled growth of abnormal cells. It spreads throughout the body which makes this disease one of the huge global threats to mankind.
Ishan Panchal +4 more
doaj +3 more sources
Iranian Journal of Allergy, Asthma and Immunology, 2020 Mouse model of multiple sclerosis (MS) is used for the inflammatory demyelinating disease. Rapamycin (RAPA) may contribute to the reduction of inflammatory responses to experimental autoimmune encephalomyelitis (EAE).
Soheila Rezapour-Firouzi +4 more
doaj +1 more source
The Complexes of Mammalian Target of Rapamycin [PDF]
Current Protein & Peptide Science, 2010 The mammalian target of rapamycin (mTOR) has attracted substantial attention because of its involvement in a variety of diseases, such as cancer, cardiac hypertrophy, diabetes and obesity. Current knowledge indicates that mTOR functions as two distinct multiprotein complexes, mTORC1 and mTORC2.
Hongyu, Zhou, Shile, Huang
openaire +2 more sources
Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression.
Yan Gao, Yi Zhang, Yangyang Fan
doaj +1 more source
Case Reports in Oncology, 2021 Through elucidating the genetic mechanisms of drug sensitivity, precision medicine aims to improve patient selection and response to therapy. Exceptional responders are patients that exhibit exquisite and durable responses to targeted therapy, providing ...
Amanda Pilling +7 more
doaj +1 more source
Insulin signaling in insulin resistance states and cancer: A modeling analysis [PDF]
, 2016 Insulin resistance is the common denominator of several diseases including type 2 diabetes and cancer, and investigating the mechanisms responsible for insulin signaling impairment is of primary importance.
Bertuzzi, Alessandro +5 more
core +14 more sources
Haematologica, 2009 Background The mammalian target of rapamycin is a conserved protein kinase known to regulate protein synthesis, cell size and proliferation. Aberrant regulation of mammalian target of rapamycin activity has been observed in hematopoietic malignancies ...
Christian R. Geest +4 more
doaj +1 more source
Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D +4 more
core +2 more sources