Results 71 to 80 of about 770,892 (320)

Sirtuins in mammals: insights into their biological function.

Biochemical Journal, 2007
Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin, Sir2 (silent information regulator 2) of Saccharomyces cerevisiae, from which the family derives its name, regulates ribosomal DNA recombination, gene ...
Shaday Michán, D. Sinclair
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Discomfort-related changes of call rate and acoustic variables of ultrasonic vocalizations in adult yellow steppe lemmings Eolagurus luteus

Scientific Reports, 2021
Potential of ultrasonic vocalizations (USVs) to reflect a degree of discomfort of a caller is mostly investigated in laboratory rats and mice but poorly known in other rodents.
Anna V. Klenova, Ilya A. Volodin, Olga G. Ilchenko, Elena V. Volodina   +3 more
doaj   +1 more source

Automatic Recognition of Mammal Genera on Camera-Trap Images using Multi-Layer Robust Principal Component Analysis and Mixture Neural Networks [PDF]

arXiv, 2017
The segmentation and classification of animals from camera-trap images is due to the conditions under which the images are taken, a difficult task. This work presents a method for classifying and segmenting mammal genera from camera-trap images. Our method uses Multi-Layer Robust Principal Component Analysis (RPCA) for segmenting, Convolutional Neural ...
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Evolutionary drivers, morphological evolution and diversity dynamics of a surviving mammal clade: cainotherioids at the Eocene--Oligocene transition [PDF]

Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2021, 288 (1952), pp.20210173. \&\#x27E8;10.1098/rspb.2021.0173\&\#x27E9, 2021
The Eocene--Oligocene transition (EOT) represents a period of global environmental changes particularly marked in Europe and coincides with a dramatic biotic turnover. Here, using an exceptional fossil preservation, we document and analyse the diversity dynamics of a mammal clade, Cainotherioidea (Artiodactyla), that survived the EOT and radiated ...
arxiv  

Functions of Polyamines in Mammals*

Journal of Biological Chemistry, 2016
The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis.
A. Pegg
semanticscholar   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Ontogeny of audible squeaks in yellow steppe lemming Eolagurus luteus: trend towards shorter and low-frequency calls is reminiscent of those in ultrasonic vocalization

BMC Zoology, 2021
Background Rodents are thought to be produced their human-audible calls (AUDs, below 20 kHz) with phonation mechanism based on vibration of the vocal folds, whereas their ultrasonic vocalizations (USVs, over 20 kHz) are produced with aerodynamic whistle ...
Ilya A. Volodin, Daria D. Yurlova, Olga G. Ilchenko, Elena V. Volodina   +3 more
doaj   +1 more source

Assessing Marine Mammal Abundance: A Novel Data Fusion [PDF]

arXiv, 2023
Marine mammals are increasingly vulnerable to human disturbance and climate change. Their diving behavior leads to limited visual access during data collection, making studying the abundance and distribution of marine mammals challenging. In theory, using data from more than one observation modality should lead to better informed predictions of ...
arxiv