Results 71 to 80 of about 60,982 (185)
Infectious Agents and Cancer, 2012 Background Controversy exists as to the ability of human gammaherpesviruses to cause or exacerbate breast cancer disease in patients. The difficulty in conducting definitive human studies can be overcome by investigating developing breast cancer in a ...
Chauhan Vinita S +4 more
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Maternal Obesity and MicroRNAs in Breast Milk: Implications for Infant Developmental Programming
Obesity Reviews, EarlyView.ABSTRACT This review explores the relationship between maternal obesity and alterations in the expression of microRNAs (miRNAs) in breast milk, highlighting how these changes may influence the developmental programming of the infant. Evidence suggests that maternal obesity can affect the bioactive composition of breast milk, including miRNA profiles ...
Gyslane M. Santos +2 more
wiley +1 more source
The Regulation and Function of Hippo/YAP Pathway in Cancer
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh +3 more
wiley +1 more source
A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus
mBio, 2019 Complex human-pathogenic retroviruses cause high morbidity and mortality worldwide, but resist antiviral drugs and vaccine development due to evasion of the immune response.
Gurvani B. Singh +8 more
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The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
International Journal of Biological Sciences, 2007 To characterize the role of BRCA1 in mammary gland development and tumor suppression, a transgenic mouse model of BRCA1 overexpression was developed. Using the mouse mammary tumor virus (MMTV) promoter/enhancer, transgenic mice expressing human BRCA1 or ...
Arichika Hoshino, Cindy J. Yee, Mel Campbell, Randall L. Woltjer, Rebecca L. Townsend, Riet van der Meer, Yu Shyr, Jeffrey T. Holt, Harold L. Moses, Roy A. Jensen
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Neoplasia: An International Journal for Oncology Research, 2008 Distant metastases of human breast cancers have been suggested to be more different from each other than from their respective primary tumors, based on expression profiling.
Shixia Huang +3 more
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AnimalsCompared to the number of studies on the neoplasms of laboratory rodents, fewer studies have focused on spontaneous neoplasms in pet rodents. Notably, the mouse mammary tumor virus (MMTV) is associated with mammary tumors in rodents.
Ya-Mei Chen, Jia-Ling Wu, Wei-Hao Lin
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Mouse Mammary Tumor Virus: New Tumor Virus or Just a Rumor Virus? [PDF]
JNCI Journal of the National Cancer Institute, 2009 W hen German microbiologist Harald zur Hausen, M.D., D.Sc., hypothesized in 1974 that human papillomavirus (HPV) played a central role in causing cervical cancer, few took him seriously. But in 1983 he discovered HPV-16, and a year later, HPV-18 in tumors of cervical cancer patients — findings that led eventually to the first preventive cancer vaccine ...
openaire +1 more source