Results 61 to 70 of about 2,239,293 (272)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

COGENT programming manual [PDF]

, 1969
COGENT /COmpiler and GENeralized Translator/ programming system is a compiler whose input language enables a description of symbolic and linguistic manipulation algorithms.
Reynolds, J. C.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Influence of Lithography Process Parameters on Continuous Surface Diffractive Optical Elements for Laser Beam Shaping

Micromachines
To address the demand for laser beam-shaping techniques, we developed a one-step exposure process based on moving-mask lithography for the fabrication of a continuous-surface diffractive optical element (DOE) for laser beam shaping.
Wenjing Liu, Axiu Cao, Junbo Liu, Hui Pang, Qiling Deng, Jian Wang, Song Hu   +6 more
doaj   +1 more source

Manipulating Biphotonic Qutrits [PDF]

Physical Review Letters, 2008
4 pages, 4 ...
Lanyon, BP, Langford, NK, Weinhold, TJ, O'Brien, JL, Resch, KJ, Gilchrist, A, White, AG   +6 more
openaire   +4 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Manipulation Robustness of Collaborative Filtering Systems

, 2009
A collaborative filtering system recommends to users products that similar users like. Collaborative filtering systems influence purchase decisions, and hence have become targets of manipulation by unscrupulous vendors.
Van Roy, Benjamin, Yan, Xiang
core   +4 more sources

Opto‐Thermal‐Tension Mediated Precision Large‐Scale Particle Manipulation and Flexible Patterning

Advanced Science
Large‐scale particle manipulation with single‐particle precision and further flexible patterning into functional structures is of huge potentials in many fields including bio‐optoelectronic sensing, colloidal lithography, and wearable devices.
Ziyi He, Jianyun Xiong, Yang Shi, Guoshuai Zhu, Xing Li, Ting Pan, Baojun Li, Hongbao Xin   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Research progress on the microbial metabolism and transport of polyamines and their roles in animal gut homeostasis

Journal of Animal Science and Biotechnology
Polyamines (putrescine, spermidine, and spermine) are aliphatic compounds ubiquitous in prokaryotes and eukaryotes. Positively charged polyamines bind to negatively charged macromolecules, such as nucleic acids and acidic phospholipids, and are involved ...
Chong Zhang, Yongkang Zhen, Yunan Weng, Jiaqi Lin, Xinru Xu, Jianjun Ma, Yuhong Zhong, Mengzhi Wang   +7 more
doaj   +1 more source