Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition [PDF]
Heliyon, 2023 Mannan-binding lectin (MBL) is a pattern-recognition molecule that plays a crucial role in innate immunity. MBL deficiency correlates with an increased risk of chronic kidney disease (CKD). However, the molecular mechanisms are not fully defined.
Li Xu +8 more
doaj +5 more sources
Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin [PDF]
Journal of Diabetes Research, 2017 Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of ...
Esben Axelgaard +3 more
doaj +7 more sources
Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein [PDF]
Fluids and Barriers of the CNS, 2012 Background Mannan-binding lectin (MBL), a protein of the innate immune response is attracting increasing clinical interest, in particularly in relation to its deficiency.
Reiber Hansotto +3 more
doaj +11 more sources
Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells [PDF]
Mediators of Inflammation, 2019 Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response. NK cell effector functions are regulated and fine-tuned by various immune modulators.
Jia Zhou +8 more
doaj +4 more sources
Decreased mannan-binding lectin level in adults with hypopituitarism; dependence on appropriate hormone replacement therapies [PDF]
Frontiers in Immunology, 2023 BackgroundMannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Although there are some studies showing links between endocrine and immune systems, the ones concerning hypopituitarism are limited. The aim of this
Aleksandra E. Matusiak +5 more
doaj +3 more sources
Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes [PDF]
Mediators of Inflammation, 2017 Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the ...
Esben Axelgaard +4 more
doaj +5 more sources
Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition [PDF]
Kidney International Reports, 2018 IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas +9 more
doaj +5 more sources
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis [PDF]
Frontiers in Immunology, 2019 Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of arthritis. However,
Lijun Dong +18 more
doaj +3 more sources
Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses [PDF]
Mediators of Inflammation, 2019 Peptidoglycan (PGN), as the major components of the bacterial cell wall, is known to cause excessive proinflammatory cytokine production. Toll-like receptor 2 (TLR2) is abundantly expressed on immune cells and has been shown to be involved in PGN-induced
Fanping Wang +16 more
doaj +3 more sources
Plasma levels of mannan-binding lectin-associated serine proteases are increased in type 1 diabetes patients with insulin resistance. [PDF]
Clin Exp Immunol, 2023 Activation of the lectin pathway of the complement system, as demonstrated by elevated levels of mannan-binding lectin proteins (MBL), contributes to vascular pathology in type 1 diabetes (T1D). Vascular complications are greatest in T1D individuals with
Kietsiriroje N +5 more
europepmc +2 more sources