Decreased mannan-binding lectin level in adults with hypopituitarism; dependence on appropriate hormone replacement therapies [PDF]
Frontiers in Immunology, 2023 BackgroundMannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Although there are some studies showing links between endocrine and immune systems, the ones concerning hypopituitarism are limited. The aim of this
Aleksandra E. Matusiak +5 more
doaj +4 more sources
Mannan-binding lectin in cardiovascular disease. [PDF]
Biomed Res Int, 2014 Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to
Pągowska-Klimek I, Cedzyński M.
europepmc +7 more sources
Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein [PDF]
Fluids and Barriers of the CNS, 2012 Background Mannan-binding lectin (MBL), a protein of the innate immune response is attracting increasing clinical interest, in particularly in relation to its deficiency.
Reiber Hansotto +3 more
doaj +8 more sources
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition [PDF]
Heliyon, 2023 Mannan-binding lectin (MBL) is a pattern-recognition molecule that plays a crucial role in innate immunity. MBL deficiency correlates with an increased risk of chronic kidney disease (CKD). However, the molecular mechanisms are not fully defined.
Li Xu +8 more
doaj +2 more sources
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis ProgressionSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Liver fibrosis represents a hallmark of most chronic liver diseases (CLD) triggered by recurrent liver injury and subsequent myofibroblast transdifferentiations of resident hepatic stellate cells (HSCs). Mannan-binding lectin (MBL)
Jialiang Luo +10 more
doaj +2 more sources
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis [PDF]
Frontiers in Immunology, 2019 Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of arthritis. However,
Lijun Dong +18 more
doaj +2 more sources
Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin [PDF]
Journal of Diabetes Research, 2017 Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of ...
Esben Axelgaard +3 more
doaj +2 more sources
Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses [PDF]
Mediators of Inflammation, 2019 Peptidoglycan (PGN), as the major components of the bacterial cell wall, is known to cause excessive proinflammatory cytokine production. Toll-like receptor 2 (TLR2) is abundantly expressed on immune cells and has been shown to be involved in PGN-induced
Fanping Wang +16 more
doaj +2 more sources
Mannan-binding lectin and hepatitis C infection [PDF]
Clinical and Experimental Immunology, 2003 SUMMARY Japanese patients with chronic hepatitis C infection unresponsive to treatment with interferon possessed genotypes disproportionately conferring low mannan-binding lectin (MBL) concentrations. Our aims were to confirm or refute this finding in European patients at the MBL protein level, and to investigate whether a low ...
David C. Kilpatrick +4 more
openalex +5 more sources
A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin. [PDF]
J Biol Chem, 2023 Iqbal H +6 more
europepmc +2 more sources