Results 91 to 100 of about 13,265 (210)

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Covalent Activation of the C‐type Lectin DC‐SIGN

Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.
We introduce the first covalent activators of a C‐type lectin. Using orthogonal functional assays, NMR, MS/MS, and computational modeling, we delineate mechanisms from a functional electrophile‐first screen on dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) that yields two modes: N‐hydroxysuccinimide (NHS ...
Jonathan Lefèbre, Maurice Besch, Noémi Csorba, Kristóf Garami, Zoltán Orgován, Gitta Schlosser, Iris Bermejo, Péter Ábrányi‐Balogh, György M. Keserű, Christoph Rademacher   +9 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Inherited deficiency of the initiator molecules of the lectin-complement pathway [PDF]

, 2010
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open)The complement system is an important immune system. Its activation results in membranolytic elimination of microbes and opsonization.
Björn Rúnar Lúðvíksson, Helga Bjarnadóttir   +1 more
core  

LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae [PDF]

, 2017
The human fungal microbiota known as mycobiota is increasingly recognized as a critical factor in human gut health and disease. Non-pathogenic commensal yeasts such as Saccharomyces cerevisiae promote homeostasis in the gut, whereas dysbiosis of the gut ...
Brown, Cadwell, Cambi, Chu, Cuskin, Delgado, Dooley Hannah, Feinberg, Hall, Ifrim, Iliev, Joffe, Kanayama, Kelesidis, Kohatsu, Laroux, Li, Ma, Macauley, Martinez, Martinez, Martinez, McGreal, Netea, Robinson, Saijo, Salehi, Sanjuan, Sato, Sokol, Tam, Underhill, van Kooyk, Viriyakosol, Wagener, Wang, Wells, West, Wex, Wheeler, Wirnsberger, Wittmann, Yonekawa, Yuan, Zhu   +44 more
core   +2 more sources

Glycan‐Mediated Grafting of Extracellular Matrix Proteins for Stable Biofunctionalization of Polystyrene Surfaces

Advanced Materials Interfaces, Volume 13, Issue 1, 7 January 2026.
We present a glycan‐mediated strategy for covalent grafting of extracellular matrix proteins onto polystyrene surfaces. This approach preserves protein bioactivity and enhances cell adhesion and viability. Using fibronectin and vitronectin, we demonstrate stable immobilization via glycosylation sites, offering a promising route for advanced ...
Mathilde Hindié, Damien Seyer, Ousmane Ba, Anthony C. Duncan, Arnaud Ponche, Olivier Gallet, Karine Anselme   +6 more
wiley   +1 more source

High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients: A retrospective cohort study

Heliyon
Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization ...
Lorena Viana de Andrade, Mirela Vanessa de Souza Sá, Beatriz Vasconcelos, Luydson Richardson Silva Vasconcelos, Ricardo Khouri, Carlos Dornels Freire de Souza, Anderson da Costa Armstrong, Rodrigo Feliciano do Carmo   +7 more
doaj   +1 more source

MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

Frontiers in Immunology, 2020
It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma, Felix Poppelaars, Wendy Dam, Anita H. Meter-Arkema, Romain R. Vivès, Peter Gál, Geert-Jan Boons, Geert-Jan Boons, Pradeep Chopra, Annamaria Naggi, Marc A. Seelen, Stephan P. Berger, Mohamed R. Daha, Coen A. Stegeman, Jacob van den Born, the COMBAT Consortium   +15 more
doaj   +1 more source

MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors. [PDF]

, 2016
It had been thought that complement factor D (FD) is activated at the site of synthesis, and only FD lacking a propeptide is present in blood. The serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and has ...
Andrea Kocsis, Anne Zeck, Dávid Szakács, Elod Kortvely, Gábor Oroszlán, Gábor Pál, József Dobó, Marius Ueffing, Péter Gál, Péter Závodszky, Sascha Dammeier   +10 more
core   +1 more source

Urinary Peptidomic Profiling In Post‐Acute Sequelae of SARS‐CoV‐2 Infection: A Case‐Control Study

PROTEOMICS, Volume 26, Issue 1, Page 32-43, January 2026.
ABSTRACT Post‐acute sequelae of severe acute respiratory syndrome coronavirus 2‐infection (PASC) is challenging to diagnose and treat, and its molecular pathophysiology remains unclear. Urinary peptidomics can provide valuable information on urine peptides that may enable improved and specified PASC diagnosis.
Dilara Gülmez, Justyna Siwy, Katharina Kurz, Ralph Wendt, Miroslaw Banasik, Björn Peters, Emmanuel Dudoignon, Francois Depret, Mercedes Salgueira, Elena Nowacki, Amelie Kurnikowski, Sebastian Mussnig, Simon Krenn, Samuel Gonos, Judith Löffler‐Ragg, Günter Weiss, Harald Mischak, Manfred Hecking, Eva Schernhammer, Joachim Beige, UriCoV Working Group   +20 more
wiley   +1 more source