Results 101 to 110 of about 14,274 (254)

High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients: A retrospective cohort study

Heliyon
Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization ...
Lorena Viana de Andrade, Mirela Vanessa de Souza Sá, Beatriz Vasconcelos, Luydson Richardson Silva Vasconcelos, Ricardo Khouri, Carlos Dornels Freire de Souza, Anderson da Costa Armstrong, Rodrigo Feliciano do Carmo   +7 more
doaj   +1 more source

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Kidney International Reports, 2018
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering   +9 more
doaj   +1 more source

MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

Frontiers in Immunology, 2020
It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma, Felix Poppelaars, Wendy Dam, Anita H. Meter-Arkema, Romain R. Vivès, Peter Gál, Geert-Jan Boons, Geert-Jan Boons, Pradeep Chopra, Annamaria Naggi, Marc A. Seelen, Stephan P. Berger, Mohamed R. Daha, Coen A. Stegeman, Jacob van den Born, the COMBAT Consortium   +15 more
doaj   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics

The Scientific World Journal, 2013
The innate immune system is evolutionary and ancient and is the pivotal line of the host defense system to protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effector
Ingrid Evans-Osses, Iara de Messias-Reason, Marcel I. Ramirez   +2 more
doaj   +1 more source

Sugary interfaces mitigate contact damage where stiff meets soft [PDF]

, 2016
The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device.
A Miserez, AM Smith, AN Zelensky, B Bar-On, B Bhushan, BP Lee, C Sun, D Gourdon, DS Hwang, E Hennebert, ED Reedy Jr, EJ Evans, GL Nicolson, H Lee, H Silverman, H Zeng, H Zhao, J Israelachvili, JH Waite, JH Waite, JH Zettl, JJ Wilker, JM Mascolo, K Ohkawa, K Ono, KJ Coyne, LA Burzio, LL Hench, M Benjamin, M Wiegemann, MA Paz, MJ Harrington, MJ Harrington, MK Kwak, MS Stanley, N Bandara, N Holten-Andersen, N Poulsen, P Fratzl, S Menon, S Suresh, T Pearce, T Pearce, WC Oliver, X-X Qin, Y Zhou   +45 more
core   +3 more sources

Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross‐Pathogen Diagnostic Universality

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Modular nanosensing platforms utilize nanomaterials and functionalized interfaces to amplify trace different pathogens (like tuberculosis) antigen capture, suppress matrix interference, and enable multiplex detection. Their portability and cost‐effectiveness support rapid screening in resource‐limited settings and real‐time monitoring, advancing high ...
Mei Li, Yuxin Luo, Wenqiang Li, Yiqing Wang, Yunze Tai, Zhiping Deng, Yao Luo   +6 more
wiley   +1 more source

MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors. [PDF]

, 2016
It had been thought that complement factor D (FD) is activated at the site of synthesis, and only FD lacking a propeptide is present in blood. The serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and has ...
Andrea Kocsis, Anne Zeck, Dávid Szakács, Elod Kortvely, Gábor Oroszlán, Gábor Pál, József Dobó, Marius Ueffing, Péter Gál, Péter Závodszky, Sascha Dammeier   +10 more
core   +1 more source

Zymoseptoria tritici stealth infection is facilitated by stage‐specific downregulation of a β‐glucanase

New Phytologist, Volume 248, Issue 6, Page 3191-3207, December 2025.
Summary Plant cell walls constitute a major defence barrier against pathogens, although it is unclear how specific cell wall components impact pathogen colonisation. Pathogens secrete cell wall‐degrading enzymes (CWDEs) to facilitate plant colonisation, but damaged or infected cells are often a source of cell wall‐derived oligosaccharides that trigger ...
Diego Rebaque, Cristian Carrasco‐López, Parvathy Krishnan, Gemma López, Sergio López‐Cobos, Felipe de Salas, Lukas Meile, Cécile Lorrain, Asier Largo‐Gosens, Bruce A. McDonald, Francisco Vilaplana, María Jesús Martínez, Hugo Mélida, Antonio Molina, Andrea Sánchez‐Vallet   +14 more
wiley   +1 more source