Results 101 to 110 of about 44,027 (268)

Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle‐Based Vaccines for Cancer Immunotherapy

Cancer Medicine, Volume 14, Issue 19, October 2025.
This study explores how antigen peptides and sugar chains affect the efficacy of glyco‐nanovaccines (iGN) in cancer immunotherapy. We show that antigen peptides, rather than sugar chains, are key to nanoparticle uptake and immune activation, with sialic acid‐modified iGN showing similar anti‐cancer efficacy to α‐mannose‐modified iGN in a mouse model ...
Narumi Harada, Mayumi Niimura, Yasuhisa Sakamoto, Akihiro Nita, Mayuko Shimoda, Shiho Wada, Koki Murata, Masahiro Wakao, Tomomi Kamba, Hiroyuki Shinchi, Toshiro Moroishi   +10 more
wiley   +1 more source

Activation of complement system by mannan pathway and Mbl2 genotypes in patients with type 2 diabetes and nephropathy

Zdravniški Vestnik, 2014
To add new evidence that complement activation by the mannan (lectin) pathway is involved in the pathogenesis of nephropathy in patients with type 2 diabetes, we collected blood and urine samples from 20 patients with type 2 diabetes and nephropathy and ...
Tjaša Cerar, Draženka Pongrac Barlovič, Anže Zorin, Nadan Gregorič, Vladimir Kotnik   +4 more
doaj  

Mannan-binding lectin regulates dendritic cell maturation and cytokine production induced by lipopolysaccharide

BMC Immunology, 2011
Background Mannan-binding lectin (MBL) is a pattern-recognition molecule present in serum, which is involved in the innate immune defense by activating complement and promoting opsonophagocytosis. Dendritic cells (DCs) are professional antigen presenting
Zhang Liyun, Chen Yue, Zhang Yani, Wang Mingyong, Lu Xiao, Chen Zhengliang   +5 more
doaj   +1 more source

MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes. [PDF]

PLoS ONE, 2014
Microbial infection urges prompt intervention by the immune system. The complement cascade and neutrophil granulocytes are the predominant contributors to this immediate anti-microbial action.
Péter K Jani, Erika Kajdácsi, Márton Megyeri, József Dobó, Zoltán Doleschall, Krisztina Futosi, Csaba I Tímár, Attila Mócsai, Veronika Makó, Péter Gál, László Cervenak   +10 more
doaj   +1 more source

Mannan‐binding lectin deficiency exacerbates sterile liver injury in mice through enhancing hepatic neutrophil recruitment

Journal of Leukocyte Biology, 2018
Noninfectious liver injury, including the effects of drugs and diet, is a major cause of liver diseases worldwide. The innate inflammatory response to hepatocyte death plays a crucial role in the outcome of liver injury.
Jia Zhou, Junru Li, Yu Yu, Yan Liu, Huifang Li, Yunzhi Liu, Jun Wang, Li-yun Zhang, Xiao Lu, Zhengliang Chen, Daming Zuo   +10 more
semanticscholar   +1 more source

Hybrid Extracellular Vesicles With Combined Functional Properties From Mesenchymal Stem Cells and Astrocytes for Targeted Neurodegenerative Disease Applications

Journal of Extracellular Vesicles, Volume 14, Issue 10, October 2025.
In this study, we established an extracellular vesicle (EV) engineering platform through membrane fusion of distinct EV populations for multifaceted therapeutic applications. Placenta‐derived mesenchymal stem cell EVs fused with astrocyte EVs were characterized by proteomic and functional profiling, revealing merged protein profiles and superior brain ...
David Wang, Kaitlin Clark, Kyle C. Rouen, Grace Baird, Tara N. Polackal, Priyadarsini Kumar, Yofiel Wyle, Diana L. Farmer, Randy P. Carney, Aijun Wang   +9 more
wiley   +1 more source

Mannan-Binding Lectin Serum Levels in 593 Healthy Iranian Children and Adults

Iranian Journal of Allergy, Asthma and Immunology, 2014
Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization.
Sara Zahedifard, Elahe Rashidi, Sedigheh Shams, Shiva Saghafi, Mohammadreza Fazlollahi, Azadeh Talebzadeh, Anoushirvan Kazemnejad, Ahmad Soltani, Zahra Pourpak   +8 more
doaj  

The C-type lectin receptor SIGNR3 binds to fungi present in commensal microbiota and influences immune regulation in experimental colitis [PDF]

, 2013
Inflammatory bowel disease is a condition of acute and chronic inflammation of the gut. An important factor contributing to pathogenesis is a dysregulated mucosal immunity against commensal bacteria and fungi.
Eriksson, Magdalena, Gruber, Achim Dieter, Johannssen, Timo, Lepenies, Bernd, Seeberger, Peter H., Smolinski, Dorthe von   +5 more
core   +1 more source

Systemic inflammatory biomarkers in relation to lung function and exercise‐induced bronchoconstriction in adolescents

Pediatric Allergy and Immunology, Volume 36, Issue 10, October 2025.
Abstract Introduction The forced oscillation technique (FOT) complements spirometry in assessing lung function, with higher sensitivity to small airway dysfunction. Systemic inflammation is thought to influence lung development and exercise‐induced bronchoconstriction (EIB), but its relationship to circulating inflammatory proteins in adolescents is ...
Karin Ersson, Kjell Alving, Margareta Emtner, Christer Janson, Henrik Johansson, Andrei Malinovschi   +5 more
wiley   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source