Results 161 to 170 of about 6,162 (208)

Mannan-Binding lectin in asthma and allergy

Current Allergy and Asthma Reports, 2006
Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing ...
Kaur, S., Thiel, Steffen, Sarma, P.U., Madan, T.   +3 more
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Assays for the Mannan‐Binding Lectin Pathway

Current Protocols in Immunology, 2003
AbstractThis unit contains protocols that can be used to measure mannan‐binding lectin (MBL) levels and MBL pathway activity in human plasma or serum. Using a modification of the conventional ELISA, the detection reagent used in the methods described (e.g., an antibody or streptavidin) is labeled with Eu3+ instead of an enzyme.
Gadjeva, Mihaela, Thiel, Steffen, Jensenius, Jens Christian   +2 more
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Mannan-Binding Lectin and Mannan-Binding Lectin-Associated Serine Protease 2 in Acute Pancreatitis

Pancreas, 2011
Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and ...
Novovic, Srdan, Andersen, Anders Møller, Ersbøll, Annette Kjær, Jorgensen, Lars N, Nielsen, Hans J, Jensenius, Jens Christian, Hansen, Mark Berner   +6 more
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Mannan binding lectin and viral hepatitis

Immunology Letters, 2007
Mannan binding lectin (MBL) is a pattern recognition molecule of the innate immune system that binds to sugars on the surface of invading micro-organisms. Target binding, complement activation and other functions of MBL are dependent on the presence of multiple carbohydrate recognition domains.
Robert B. Sim, Timothy P. Hickling, William L. Irving, Stephen D. Ryder, Kristelle Brown   +4 more
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Recombinant expression of human mannan-binding lectin

International Immunopharmacology, 2001
Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance.
Vorup-Jensen, T, Sørensen, Esben Skipper, Jensen, Uffe Birk, Schwaeble, W, Kawasaki, T, Ma, Yong, Uemura, K, Wakamiya, N, Suzuki, Y, Jensen, T G, Takahashi, K, Ezekowitz, R A, Thiel, S, Jensenius, J C   +13 more
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Recombinant mannan-binding lectin (MBL) for therapy

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) is a plasma protein involved in the innate immune response. It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization. Clinical evidence indicates that in a variety of situations genetically determined low MBL levels are associated with ...
Jensenius, Jens Christian, Jensen, P H, McGuire, K, Larsen, J L, Thiel, S   +4 more
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Introduction to mannan-binding lectin

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) was first discovered as a plasma opsonin for baker's yeast and was independently characterized biochemically. It belongs to the small subfamily of collectins: C-type lectins possessing a collagen-like domain. MBL is synthesized by the liver and secreted into the bloodstream.
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Mannan‐Binding Lectin in Children with Chronic Gastritis

Scandinavian Journal of Immunology, 2006
AbstractThe involvement of mannan‐binding lectin (MBL) insufficiency in the pathogenesis of chronic gastritis (CG) in children was investigated. Blood samples were collected from 78 paediatric patients suffering from CG associated with Helicobacter pylori infection (group Hp+) and from 41 with the disease not associated with such an infection (group Hp–
Andrzej Kałużyński, Maciej Cedzynski, Janusz Szemraj, A. St. Swierzko, Krzysztof Zeman, Izabela Płaneta-Małecka, Leokadia Bak-Romaniszyn   +6 more
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Mannan-binding lectin and healing of a radiation-induced chronic ulcer – a case report on mannan-binding lectin replacement therapy [PDF]

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2011
Mannan-binding lectin is an important component of innate immunity, and insufficiency is associated with several clinical disorders. Recently, experimental replacement therapy with plasma-derived mannan-binding lectin has become an option. The current article presents the case of a patient with an insufficient level of mannan-binding lectin and a ...
Maaløe, Nanna, Bonde, C, Laursen, I, Christiansen, M., Hölmich, L R   +4 more
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Biochemistry and genetics of mannan-binding lectin (MBL)

Biochemical Society Transactions, 2003
Mannose- or mannan-binding lectin (MBL) is a member of the collectin protein family, which includes lung surfactant proteins SP-A and SP-D. Each member consists of similar or identical polypeptide chains with a region of collagen-like sequence followed by a C-type lectin domain.
M. Kojima, Julia S. Presanis, Robert B. Sim   +2 more
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