Results 161 to 170 of about 6,257 (206)

Mannan-Binding Lectin and Mannan-Binding Lectin-Associated Serine Protease 2 in Acute Pancreatitis

Pancreas, 2011
Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and ...
Novovic, Srdan, Andersen, Anders Møller, Ersbøll, Annette Kjær, Jorgensen, Lars N, Nielsen, Hans J, Jensenius, Jens Christian, Hansen, Mark Berner   +6 more
openaire   +6 more sources

Mannan binding lectin and viral hepatitis

Immunology Letters, 2007
Mannan binding lectin (MBL) is a pattern recognition molecule of the innate immune system that binds to sugars on the surface of invading micro-organisms. Target binding, complement activation and other functions of MBL are dependent on the presence of multiple carbohydrate recognition domains.
Robert B. Sim, Timothy P. Hickling, William L. Irving, Stephen D. Ryder, Kristelle Brown   +4 more
openaire   +3 more sources

Recombinant expression of human mannan-binding lectin

International Immunopharmacology, 2001
Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance.
Vorup-Jensen, T, Sørensen, Esben Skipper, Jensen, Uffe Birk, Schwaeble, W, Kawasaki, T, Ma, Yong, Uemura, K, Wakamiya, N, Suzuki, Y, Jensen, T G, Takahashi, K, Ezekowitz, R A, Thiel, S, Jensenius, J C   +13 more
openaire   +4 more sources

Recombinant mannan-binding lectin (MBL) for therapy

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) is a plasma protein involved in the innate immune response. It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization. Clinical evidence indicates that in a variety of situations genetically determined low MBL levels are associated with ...
Jensenius, Jens Christian, Jensen, P H, McGuire, K, Larsen, J L, Thiel, S   +4 more
openaire   +3 more sources

Introduction to mannan-binding lectin

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) was first discovered as a plasma opsonin for baker's yeast and was independently characterized biochemically. It belongs to the small subfamily of collectins: C-type lectins possessing a collagen-like domain. MBL is synthesized by the liver and secreted into the bloodstream.
openaire   +3 more sources

Mannan‐Binding Lectin in Children with Chronic Gastritis

Scandinavian Journal of Immunology, 2006
AbstractThe involvement of mannan‐binding lectin (MBL) insufficiency in the pathogenesis of chronic gastritis (CG) in children was investigated. Blood samples were collected from 78 paediatric patients suffering from CG associated with Helicobacter pylori infection (group Hp+) and from 41 with the disease not associated with such an infection (group Hp–
Andrzej Kałużyński, Maciej Cedzynski, Janusz Szemraj, A. St. Swierzko, Krzysztof Zeman, Izabela Płaneta-Małecka, Leokadia Bak-Romaniszyn   +6 more
openaire   +3 more sources

Mannan-binding lectin and healing of a radiation-induced chronic ulcer – a case report on mannan-binding lectin replacement therapy [PDF]

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2011
Mannan-binding lectin is an important component of innate immunity, and insufficiency is associated with several clinical disorders. Recently, experimental replacement therapy with plasma-derived mannan-binding lectin has become an option. The current article presents the case of a patient with an insufficient level of mannan-binding lectin and a ...
Maaløe, Nanna, Bonde, C, Laursen, I, Christiansen, M., Hölmich, L R   +4 more
openaire   +3 more sources

Mannan binding lectin concentration and risk of miscarriage

Human Reproduction, 1999
Recurrent miscarriage is associated with low concentrations of mannan-binding lectin (MBL), but it is not known below which value relative MBL deficiency becomes a significant risk factor. The sera of 397 patients (male and female) suffering from recurrent miscarriage and 376 controls were assayed for MBL and the data analysed.
D.C. Kilpatrick, W.A. Liston, L. Starrs, S. Moore, V. Souter   +4 more
openaire   +3 more sources

Biochemistry and genetics of mannan-binding lectin (MBL)

Biochemical Society Transactions, 2003
Mannose- or mannan-binding lectin (MBL) is a member of the collectin protein family, which includes lung surfactant proteins SP-A and SP-D. Each member consists of similar or identical polypeptide chains with a region of collagen-like sequence followed by a C-type lectin domain.
M. Kojima, Julia S. Presanis, Robert B. Sim   +2 more
openaire   +3 more sources

Mannan-binding lectin?a soluble pattern recognition molecule

Molecular Immunology, 2004
The immune system must discriminate between self and non-self. Mannan-binding lectin (MBL) is a recognition molecule able to differentiate between the carbohydrates found on self glycoproteins and the carbohydrate patterns found on infectious non-self surfaces. It exists in a complex with MBL-associated serine proteases (MASPs).
Gadjeva, Mihaela, Takahashi, Kazue, Thiel, Steffen   +2 more
openaire   +5 more sources