Results 161 to 170 of about 13,265 (210)

Mannan binding lectin and viral hepatitis

Immunology Letters, 2007
Mannan binding lectin (MBL) is a pattern recognition molecule of the innate immune system that binds to sugars on the surface of invading micro-organisms. Target binding, complement activation and other functions of MBL are dependent on the presence of multiple carbohydrate recognition domains.
Kristelle S, Brown, Stephen D, Ryder, William L, Irving, Robert B, Sim, Timothy P, Hickling   +4 more
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Mannan-Binding lectin in asthma and allergy

Current Allergy and Asthma Reports, 2006
Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing ...
Kaur, S., Thiel, Steffen, Sarma, P.U., Madan, T.   +3 more
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Assays for the Mannan‐Binding Lectin Pathway

Current Protocols in Immunology, 2003
AbstractThis unit contains protocols that can be used to measure mannan‐binding lectin (MBL) levels and MBL pathway activity in human plasma or serum. Using a modification of the conventional ELISA, the detection reagent used in the methods described (e.g., an antibody or streptavidin) is labeled with Eu3+ instead of an enzyme.
Gadjeva, Mihaela, Thiel, Steffen, Jensenius, Jens Christian   +2 more
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Recombinant expression of human mannan-binding lectin

International Immunopharmacology, 2001
Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance.
Vorup-Jensen, T, Sørensen, Esben Skipper, Jensen, Uffe Birk, Schwaeble, W, Kawasaki, T, Ma, Yong, Uemura, K, Wakamiya, N, Suzuki, Y, Jensen, T G, Takahashi, K, Ezekowitz, R A, Thiel, S, Jensenius, J C   +13 more
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Recombinant mannan-binding lectin (MBL) for therapy

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) is a plasma protein involved in the innate immune response. It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization. Clinical evidence indicates that in a variety of situations genetically determined low MBL levels are associated with ...
Jensenius, Jens Christian, Jensen, P H, McGuire, K, Larsen, J L, Thiel, S   +4 more
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Introduction to mannan-binding lectin

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) was first discovered as a plasma opsonin for baker's yeast and was independently characterized biochemically. It belongs to the small subfamily of collectins: C-type lectins possessing a collagen-like domain. MBL is synthesized by the liver and secreted into the bloodstream.
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Mannan-binding lectin?a soluble pattern recognition molecule

Molecular Immunology, 2004
The immune system must discriminate between self and non-self. Mannan-binding lectin (MBL) is a recognition molecule able to differentiate between the carbohydrates found on self glycoproteins and the carbohydrate patterns found on infectious non-self surfaces. It exists in a complex with MBL-associated serine proteases (MASPs).
Gadjeva, Mihaela, Takahashi, Kazue, Thiel, Steffen   +2 more
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Mannan-binding lectin: clinical significance and applications

Biochimica et Biophysica Acta (BBA) - General Subjects, 2002
Mannan-binding lectin (MBL) is a collectin (protein with both collagen-like and C-type lectin domains) synthesised in the liver and secreted into the bloodstream. Its plasma concentration is for the most part genetically determined by a series of allelic dimorphisms located both in the structural gene and in the promoter region.
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Mannan‐Binding Lectin in Children with Chronic Gastritis

Scandinavian Journal of Immunology, 2006
AbstractThe involvement of mannan‐binding lectin (MBL) insufficiency in the pathogenesis of chronic gastritis (CG) in children was investigated. Blood samples were collected from 78 paediatric patients suffering from CG associated with Helicobacter pylori infection (group Hp+) and from 41 with the disease not associated with such an infection (group Hp–
L, Bak-Romaniszyn, M, Cedzyński, J, Szemraj, A, St Swierzko, K, Zeman, A, Kałuzyński, I, Płaneta-Małecka   +6 more
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Mannan binding lectin concentration and risk of miscarriage

Human Reproduction, 1999
Recurrent miscarriage is associated with low concentrations of mannan-binding lectin (MBL), but it is not known below which value relative MBL deficiency becomes a significant risk factor. The sera of 397 patients (male and female) suffering from recurrent miscarriage and 376 controls were assayed for MBL and the data analysed.
D C, Kilpatrick, L, Starrs, S, Moore, V, Souter, W A, Liston   +4 more
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