Results 171 to 180 of about 6,257 (206)

An assay for the mannan-binding lectin pathway of complement activation

Journal of Immunological Methods, 2001
The mannan-binding lectin (MBL) pathway of complement activation has been established as the third pathway of complement activation. MBL is a carbohydrate-binding serum protein, which circulates in complex with serine proteases known as mannan-binding lectin associated serine proteases (MASPs).
Petersen, Steen Vang, Thiel, S, Jensen, L, Steffensen, R, Jensenius, J C   +4 more
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The mannan-binding-lectin pathway of the innate immune response

Current Opinion in Immunology, 2001
Dramatic progress has been achieved during the past year in our understanding of how the complement system is activated via the mannan-binding-lectin pathway. Surprising discoveries have changed our concepts of the complexes that are formed upon engagement of mannan-binding lectin with its serine proteases.
Gadjeva, M., Thiel, S., Jensenius, J.C.
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Mannan-binding lectin: clinical significance and applications

Biochimica et Biophysica Acta (BBA) - General Subjects, 2002
Mannan-binding lectin (MBL) is a collectin (protein with both collagen-like and C-type lectin domains) synthesised in the liver and secreted into the bloodstream. Its plasma concentration is for the most part genetically determined by a series of allelic dimorphisms located both in the structural gene and in the promoter region.
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The effect of mannan-binding lectin on opsonophagocytosis of Neisseria meningitidis

Immunopharmacology, 1997
Mannan-binding lectin (MBL), an acute phase protein with a structure and a function very similar to that of C1q, is known to act as an opsonin binding to a number of microorganisms. In order to investigate the effect of MBL on the phagocytic killing of meningococci, a serogroup B meningococcal strain (H44/76) and its unencapsulated variant v24, as well
Drogari-Apiranthitou, M, Fijen, C A, Thiel, S, Platonov, A, Jensen, L, Dankert, J, Kuijper, E J   +6 more
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Genetic influences on mannan‐binding lectin (MBL) and mannan‐binding lectin associated serine protease‐2 (MASP‐2) activity

Genetic Epidemiology, 2006
AbstractThe lectin pathway of the complement system is activated when Mannan‐binding lectin (MBL) in complex with MASP‐2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease.
Sorensen, Grith L, Petersen, Inge, Thiel, Steffen, Fenger, Mogens, Christensen, Kaare, Kyvik, Kirsten O, Sørensen, Thorkild I A, Holmskov, Uffe, Jensenius, Jens Christian   +8 more
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Mannan binding lectin and the sudden infant death syndrome

Forensic Science International, 1998
Mannan binding lectin (MBL) may be important for innate immunity and some cases of sudden infant death syndrome (SIDS) may be preceded by bacterial infection. Therefore, relative MBL deficiency might be associated with susceptibility to SIDS. We measured MBL concentrations in 46 SIDS infants and 26 controls.
V. S. James, Anthony Busuttil, Donald M. Weir, D.C Kilpatrick, N.F Hallam, C. Caroline Blackwell   +5 more
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Mannan-Binding Lectin of the Sea Urchin Strongylocentrotus nudus

Marine Biotechnology, 2012
A novel lectin specific to low-branched mannans (MBL-SN) was isolated from coelomic plasma of the sea urchin Strongylocentrotus nudus by combining anion-exchange liquid chromatography on DEAE Toyopearl 650 M, affinity chromatography on mannan-Sepharose and gel filtration on the Sephacryl S-200.
Ekaterina V. Shamshurina, Ekaterina V. Shamshurina, M. G. Eliseikina, Galina N. Likhatskaya, Valery A. Rasskazov, Svetlana N. Kovalchuk, Svetlana N. Kovalchuk, Irina Yu Petrova, A. A. Bulgakov   +8 more
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RECOMBINANT HUMAN MANNAN-BINDING LECTIN

1999
The present invention relates to methods of producing and/or isolating MEL compositions. In particular the inven­tion relates to methods of producing and/or isolating novel recombinant human MEL preparations with high similarity to natural human MEL.
Vorup-Jensen, Thomas, Thiel, S., Jensenius, J.C.   +2 more
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Single-nucleotide polymorphisms in porcine mannan-binding lectin A

Immunogenetics, 2006
The MBL1 and MBL2 genes encode mannan-binding lectins (MBL) A and C, respectively, that are collagenous lectins (collectins) produced mainly by the liver. Several single-nucleotide polymorphisms (SNPs) in the human MBL2 gene are responsible for various innate immune dysfunctions due to abnormal structure or expression of human MBL-C.
Lillie, B., Keirstead, N., Squires, E., Hayes, M.   +3 more
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Mannan-binding protein, a complement activating animal lectin

Immunopharmacology, 1992
Mannan-binding protein is an animal serum lectin (i.e. a molecule with the ability to bind specifically to certain carbohydrate structures). The relevant carbohydrate ligands are found on many pathogenic microorganisms. After binding to suitable carbohydrate ligands, mannan-binding protein is found to be an activator of the classical pathway of ...
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