Results 171 to 180 of about 6,162 (208)

Mannan binding lectin concentration and risk of miscarriage

Human Reproduction, 1999
Recurrent miscarriage is associated with low concentrations of mannan-binding lectin (MBL), but it is not known below which value relative MBL deficiency becomes a significant risk factor. The sera of 397 patients (male and female) suffering from recurrent miscarriage and 376 controls were assayed for MBL and the data analysed.
D.C. Kilpatrick, W.A. Liston, L. Starrs, S. Moore, V. Souter   +4 more
openaire   +3 more sources

Mannan-binding lectin?a soluble pattern recognition molecule

Molecular Immunology, 2004
The immune system must discriminate between self and non-self. Mannan-binding lectin (MBL) is a recognition molecule able to differentiate between the carbohydrates found on self glycoproteins and the carbohydrate patterns found on infectious non-self surfaces. It exists in a complex with MBL-associated serine proteases (MASPs).
Gadjeva, Mihaela, Takahashi, Kazue, Thiel, Steffen   +2 more
openaire   +5 more sources

The mannan-binding-lectin pathway of the innate immune response

Current Opinion in Immunology, 2001
Dramatic progress has been achieved during the past year in our understanding of how the complement system is activated via the mannan-binding-lectin pathway. Surprising discoveries have changed our concepts of the complexes that are formed upon engagement of mannan-binding lectin with its serine proteases.
Gadjeva, M., Thiel, S., Jensenius, J.C.
openaire   +5 more sources

An assay for the mannan-binding lectin pathway of complement activation

Journal of Immunological Methods, 2001
The mannan-binding lectin (MBL) pathway of complement activation has been established as the third pathway of complement activation. MBL is a carbohydrate-binding serum protein, which circulates in complex with serine proteases known as mannan-binding lectin associated serine proteases (MASPs).
Petersen, Steen Vang, Thiel, S, Jensen, L, Steffensen, R, Jensenius, J C   +4 more
openaire   +5 more sources

Mannan-binding lectin: clinical significance and applications

Biochimica et Biophysica Acta (BBA) - General Subjects, 2002
Mannan-binding lectin (MBL) is a collectin (protein with both collagen-like and C-type lectin domains) synthesised in the liver and secreted into the bloodstream. Its plasma concentration is for the most part genetically determined by a series of allelic dimorphisms located both in the structural gene and in the promoter region.
openaire   +3 more sources

The effect of mannan-binding lectin on opsonophagocytosis of Neisseria meningitidis

Immunopharmacology, 1997
Mannan-binding lectin (MBL), an acute phase protein with a structure and a function very similar to that of C1q, is known to act as an opsonin binding to a number of microorganisms. In order to investigate the effect of MBL on the phagocytic killing of meningococci, a serogroup B meningococcal strain (H44/76) and its unencapsulated variant v24, as well
Drogari-Apiranthitou, M, Fijen, C A, Thiel, S, Platonov, A, Jensen, L, Dankert, J, Kuijper, E J   +6 more
openaire   +4 more sources

Genetic influences on mannan‐binding lectin (MBL) and mannan‐binding lectin associated serine protease‐2 (MASP‐2) activity

Genetic Epidemiology, 2006
AbstractThe lectin pathway of the complement system is activated when Mannan‐binding lectin (MBL) in complex with MASP‐2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease.
Sorensen, Grith L, Petersen, Inge, Thiel, Steffen, Fenger, Mogens, Christensen, Kaare, Kyvik, Kirsten O, Sørensen, Thorkild I A, Holmskov, Uffe, Jensenius, Jens Christian   +8 more
openaire   +6 more sources

Mannan binding lectin and the sudden infant death syndrome

Forensic Science International, 1998
Mannan binding lectin (MBL) may be important for innate immunity and some cases of sudden infant death syndrome (SIDS) may be preceded by bacterial infection. Therefore, relative MBL deficiency might be associated with susceptibility to SIDS. We measured MBL concentrations in 46 SIDS infants and 26 controls.
V. S. James, Anthony Busuttil, Donald M. Weir, D.C Kilpatrick, N.F Hallam, C. Caroline Blackwell   +5 more
openaire   +3 more sources

Mannan-Binding Lectin of the Sea Urchin Strongylocentrotus nudus

Marine Biotechnology, 2012
A novel lectin specific to low-branched mannans (MBL-SN) was isolated from coelomic plasma of the sea urchin Strongylocentrotus nudus by combining anion-exchange liquid chromatography on DEAE Toyopearl 650 M, affinity chromatography on mannan-Sepharose and gel filtration on the Sephacryl S-200.
Ekaterina V. Shamshurina, Ekaterina V. Shamshurina, M. G. Eliseikina, Galina N. Likhatskaya, Valery A. Rasskazov, Svetlana N. Kovalchuk, Svetlana N. Kovalchuk, Irina Yu Petrova, A. A. Bulgakov   +8 more
openaire   +3 more sources

RECOMBINANT HUMAN MANNAN-BINDING LECTIN

1999
The present invention relates to methods of producing and/or isolating MEL compositions. In particular the inven­tion relates to methods of producing and/or isolating novel recombinant human MEL preparations with high similarity to natural human MEL.
Vorup-Jensen, Thomas, Thiel, S., Jensenius, J.C.   +2 more
openaire   +2 more sources