Results 171 to 180 of about 13,265 (210)

RECOMBINANT HUMAN MANNAN-BINDING LECTIN

1999
The present invention relates to methods of producing and/or isolating MEL compositions. In particular the inven­tion relates to methods of producing and/or isolating novel recombinant human MEL preparations with high similarity to natural human MEL.
Vorup-Jensen, Thomas, Thiel, S., Jensenius, J.C.   +2 more
openaire   +2 more sources

Biochemistry and genetics of mannan-binding lectin (MBL)

Biochemical Society Transactions, 2003
Mannose- or mannan-binding lectin (MBL) is a member of the collectin protein family, which includes lung surfactant proteins SP-A and SP-D. Each member consists of similar or identical polypeptide chains with a region of collagen-like sequence followed by a C-type lectin domain.
J S, Presanis, M, Kojima, R B, Sim
openaire   +2 more sources

Genetic influences on mannan‐binding lectin (MBL) and mannan‐binding lectin associated serine protease‐2 (MASP‐2) activity

Genetic Epidemiology, 2006
AbstractThe lectin pathway of the complement system is activated when Mannan‐binding lectin (MBL) in complex with MASP‐2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease.
Sorensen, Grith L, Petersen, Inge, Thiel, Steffen, Fenger, Mogens, Christensen, Kaare, Kyvik, Kirsten O, Sørensen, Thorkild I A, Holmskov, Uffe, Jensenius, Jens Christian   +8 more
openaire   +5 more sources

Mannan-binding lectin (MBL) production from human plasma

Biochemical Society Transactions, 2003
Individuals with low levels of mannan-binding lectin (MBL) appear to be susceptible to infectious diseases. This suggests that substitution therapy with MBL might be a beneficial treatment of patients with MBL deficiency. A production process for an MBL product has been developed from a fraction II+III precipitate obtained by ethanol fractionation of ...
openaire   +2 more sources

Mannan binding lectin and the sudden infant death syndrome

Forensic Science International, 1998
Mannan binding lectin (MBL) may be important for innate immunity and some cases of sudden infant death syndrome (SIDS) may be preceded by bacterial infection. Therefore, relative MBL deficiency might be associated with susceptibility to SIDS. We measured MBL concentrations in 46 SIDS infants and 26 controls.
D C, Kilpatrick, V S, James, C C, Blackwell, D M, Weir, N F, Hallam, A, Busuttil   +5 more
openaire   +2 more sources

Mannan-Binding Lectin of the Sea Urchin Strongylocentrotus nudus

Marine Biotechnology, 2012
A novel lectin specific to low-branched mannans (MBL-SN) was isolated from coelomic plasma of the sea urchin Strongylocentrotus nudus by combining anion-exchange liquid chromatography on DEAE Toyopearl 650 M, affinity chromatography on mannan-Sepharose and gel filtration on the Sephacryl S-200.
Aleksandr A, Bulgakov, Marina G, Eliseikina, Svetlana N, Kovalchuk, Irina Yu, Petrova, Galina N, Likhatskaya, Ekaterina V, Shamshurina, Valery A, Rasskazov   +6 more
openaire   +2 more sources

Mannan-binding protein, a complement activating animal lectin

Immunopharmacology, 1992
Mannan-binding protein is an animal serum lectin (i.e. a molecule with the ability to bind specifically to certain carbohydrate structures). The relevant carbohydrate ligands are found on many pathogenic microorganisms. After binding to suitable carbohydrate ligands, mannan-binding protein is found to be an activator of the classical pathway of ...
openaire   +3 more sources

Phospholipid-binding activity of human mannan-binding lectin

Immunology Letters, 1998
Some C-type lectins possess phospholipid-binding ability, which may be of physiological importance. Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. This property was inhibited by
openaire   +2 more sources

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

Signal Transduction and Targeted Therapy, 2022
Lin Zhu, Shoudeng Chen, Xiu-Wu Bian
exaly  

Mannan-Binding Lectin Polymorphisms and Infectious Diseases

2008
Møller-Kristensen, Mette, Thiel, Steffen, Jensenius, Jens Christian   +2 more
openaire   +3 more sources