The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]
PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali +15 more
doaj +6 more sources
Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. [PDF]
PLoS ONE, 2015 Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a ...
Shushimita Shushimita +5 more
doaj +9 more sources
Therapeutic applications of mannan-binding lectin [PDF]
The Biochemist, 2003 Mannan-binding lectin (MBL) is perhaps the best known of the collectins, a subfamily of C-type lectins possessing an additional collagen-like domain. MBL is thought to be an important component of innate immunity. Since the discovery, around 15 years ago, that MBL was identical to a factor responsible for the opsonization of baker's yeast in vitro, a ...
David C. Kilpatrick
openalex +2 more sources
Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin. [PDF]
PLoS ONE, 2014 Lysyl hydroxylase 3 (LH3) is a multifunctional protein with lysyl hydroxylase, galactosyltransferase and glucosyltransferase activities. The LH3 has been shown to modify the lysine residues both in collagens and also in some collagenous proteins. In this
Maija Risteli +5 more
doaj +2 more sources
Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes [PDF]
Journal of Diabetes Research, 2017 Objective. Mannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk of diabetic nephropathy.
Gry Høst Dørflinger +4 more
doaj +2 more sources
Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells [PDF]
Mediators of Inflammation, 2019 Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response. NK cell effector functions are regulated and fine-tuned by various immune modulators.
Jia Zhou +8 more
doaj +2 more sources
Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes [PDF]
Mediators of Inflammation, 2017 Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the ...
Esben Axelgaard +4 more
doaj +2 more sources
Plasma levels of mannan-binding lectin-associated serine proteases are increased in type 1 diabetes patients with insulin resistance. [PDF]
Clin Exp Immunol, 2023 Kietsiriroje N +5 more
europepmc +3 more sources
Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer
Swiss Medical Weekly, 2011 QUESTIONS UNDER STUDY: Mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are two key components of the lectin-pathway of complement-activation. Information on the potential role of lectin-pathway components in carcinogenesis
UP Fisch +6 more
doaj +3 more sources
Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model [PDF]
Journal of Diabetes Research, 2016 Background. Diabetic kidney disease is the leading cause of end-stage renal failure despite intensive treatment of modifiable risk factors. Identification of new drug targets is therefore of paramount importance.
Jakob Appel Østergaard +6 more
doaj +2 more sources