Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition [PDF]
Heliyon, 2023 Mannan-binding lectin (MBL) is a pattern-recognition molecule that plays a crucial role in innate immunity. MBL deficiency correlates with an increased risk of chronic kidney disease (CKD). However, the molecular mechanisms are not fully defined.
Li Xu +8 more
doaj +4 more sources
Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin [PDF]
Journal of Diabetes Research, 2017 Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of ...
Esben Axelgaard +3 more
doaj +6 more sources
Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein [PDF]
Fluids and Barriers of the CNS, 2012 Background Mannan-binding lectin (MBL), a protein of the innate immune response is attracting increasing clinical interest, in particularly in relation to its deficiency.
Reiber Hansotto +3 more
doaj +8 more sources
Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells [PDF]
Mediators of Inflammation, 2019 Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response. NK cell effector functions are regulated and fine-tuned by various immune modulators.
Jia Zhou +8 more
doaj +3 more sources
Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes [PDF]
Mediators of Inflammation, 2017 Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the ...
Esben Axelgaard +4 more
doaj +4 more sources
Decreased mannan-binding lectin level in adults with hypopituitarism; dependence on appropriate hormone replacement therapies [PDF]
Frontiers in Immunology, 2023 BackgroundMannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Although there are some studies showing links between endocrine and immune systems, the ones concerning hypopituitarism are limited. The aim of this
Aleksandra E. Matusiak +5 more
doaj +2 more sources
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis [PDF]
Frontiers in Immunology, 2019 Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of arthritis. However,
Lijun Dong +18 more
doaj +2 more sources
Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses [PDF]
Mediators of Inflammation, 2019 Peptidoglycan (PGN), as the major components of the bacterial cell wall, is known to cause excessive proinflammatory cytokine production. Toll-like receptor 2 (TLR2) is abundantly expressed on immune cells and has been shown to be involved in PGN-induced
Fanping Wang +16 more
doaj +2 more sources
Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin. [PDF]
PLoS ONE, 2014 Lysyl hydroxylase 3 (LH3) is a multifunctional protein with lysyl hydroxylase, galactosyltransferase and glucosyltransferase activities. The LH3 has been shown to modify the lysine residues both in collagens and also in some collagenous proteins. In this
Maija Risteli +5 more
doaj +2 more sources
Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. [PDF]
PLoS ONE, 2015 Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a ...
Shushimita Shushimita +5 more
doaj +2 more sources