Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes [PDF]
Mediators of Inflammation, 2017 Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the ...
Esben Axelgaard +4 more
doaj +2 more sources
Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes [PDF]
Journal of Diabetes Research, 2017 Objective. Mannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk of diabetic nephropathy.
Gry Høst Dørflinger +4 more
doaj +2 more sources
Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells [PDF]
Mediators of Inflammation, 2019 Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response. NK cell effector functions are regulated and fine-tuned by various immune modulators.
Jia Zhou +8 more
doaj +2 more sources
Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition [PDF]
Kidney International Reports, 2018 IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas +9 more
doaj +2 more sources
Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model [PDF]
Journal of Diabetes Research, 2016 Background. Diabetic kidney disease is the leading cause of end-stage renal failure despite intensive treatment of modifiable risk factors. Identification of new drug targets is therefore of paramount importance.
Jakob Appel Østergaard +6 more
doaj +2 more sources
Mannan-binding lectin in cardiovascular disease. [PDF]
Biomed Res Int, 2014 Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to
Pągowska-Klimek I, Cedzyński M.
europepmc +5 more sources
3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors
Frontiers in Molecular Biosciences, 2021 Humans and other mammals resist exogenous pathogens by recognizing them as non-self. How do they do this? The answer lies in the recognition by mammalian lectin receptors of glycans usually found on the surface of pathogens and whose chemical structure ...
Noriyoshi Manabe, Yoshiki Yamaguchi
doaj +1 more source
A novel bifunctional hybrid with marine bacterium alkaline phosphatase and Far Eastern holothurian mannan-binding lectin activities. [PDF]
PLoS ONE, 2014 A fusion between the genes encoding the marine bacterium Cobetia marina alkaline phosphatase (CmAP) and Far Eastern holothurian Apostichopus japonicus mannan-binding C-type lectin (MBL-AJ) was performed. Expression of the fusion gene in E.
Larissa Balabanova +6 more
doaj +1 more source
Thyroid hormone increases mannan-binding lectin levels [PDF]
European Journal of Endocrinology, 2005 Background: Recent studies have indicated the existence of causal links between the endocrine and immune systems and cardiovascular disease. Mannan-binding lectin (MBL), a protein of the innate immune system, may constitute a connection between these fields.
Riis, Anne Lene Dalkjaer +8 more
openaire +3 more sources
Letter to the Editor: LO2, a misidentified cell line: Some data should be interpreted with caution
, 2022 Hepatology, EarlyView.
Ralf Weiskirchen
wiley +1 more source