Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin. [PDF]
PLoS ONE, 2014 Lysyl hydroxylase 3 (LH3) is a multifunctional protein with lysyl hydroxylase, galactosyltransferase and glucosyltransferase activities. The LH3 has been shown to modify the lysine residues both in collagens and also in some collagenous proteins. In this
Maija Risteli +5 more
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Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition [PDF]
Kidney International Reports, 2018 IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas +9 more
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Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes [PDF]
Journal of Diabetes Research, 2017 Objective. Mannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk of diabetic nephropathy.
Gry Høst Dørflinger +4 more
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A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin. [PDF]
J Biol Chem, 2023 Iqbal H +6 more
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Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model [PDF]
Journal of Diabetes Research, 2016 Background. Diabetic kidney disease is the leading cause of end-stage renal failure despite intensive treatment of modifiable risk factors. Identification of new drug targets is therefore of paramount importance.
Jakob Appel Østergaard +6 more
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Therapeutic applications of mannan-binding lectin [PDF]
The Biochemist, 2003 Mannan-binding lectin (MBL) is perhaps the best known of the collectins, a subfamily of C-type lectins possessing an additional collagen-like domain. MBL is thought to be an important component of innate immunity. Since the discovery, around 15 years ago, that MBL was identical to a factor responsible for the opsonization of baker's yeast in vitro, a ...
David C. Kilpatrick
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Clinical manifestations of mannan-binding lectin deficiency
Molecular Immunology, 2005 Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune system.
Steffen Thiel +2 more
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Mannan-Binding Lectin Is Associated with Inflammation and Kidney Damage in a Mouse Model of Type 2 Diabetes. [PDF]
Int J Mol SciDørflinger GH +5 more
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Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. [PDF]
Front ImmunolHymøller KM +5 more
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Recognition of <i>Staphylococcus aureus</i> by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. [PDF]
Front ImmunolHymøller KM +5 more
europepmc +2 more sources