Results 21 to 30 of about 6,257 (206)

Mannan-binding lectin in cardiovascular disease. [PDF]

Biomed Res Int, 2014
Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to
Pągowska-Klimek I, Cedzyński M.
europepmc   +5 more sources

Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury. [PDF]

J Neuroinflammation
Mercurio D, Pischiutta F, Seminara S, Tribuzio F, Lisi I, Pasetto L, Bonetto V, De Simoni MG, Schwaeble W, Yaseen S, Dudler T, Zanier ER, Fumagalli S.   +12 more
europepmc   +2 more sources

3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors

Frontiers in Molecular Biosciences, 2021
Humans and other mammals resist exogenous pathogens by recognizing them as non-self. How do they do this? The answer lies in the recognition by mammalian lectin receptors of glycans usually found on the surface of pathogens and whose chemical structure ...
Noriyoshi Manabe, Yoshiki Yamaguchi
doaj   +1 more source

Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis [PDF]

Infection and Immunity, 2001
ABSTRACTLevels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonizedLeishmania chagasipromastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites.
Isabel Kinney Ferreira de Miranda Santos, Carlos Henrique Nery Costa, Henrique Krieger, Mary F. Feitosa, David Zurakowski, Babak Fardin, Régis Gomes, Debra L. Weiner, Donald A. Harn, R. Alan B. Ezekowitz, Judith E. Epstein   +10 more
openalex   +4 more sources

Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels.

PLoS Neglected Tropical Diseases, 2020
BackgroundDeposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement.
Hellen Weinschutz Mendes, Angelica Beate Winter Boldt, Ewalda von Rosen Seeling Stahlke, Jens Christian Jensenius, Steffen Thiel, Iara J Taborda Messias-Reason   +5 more
doaj   +1 more source

Dengue and the Lectin Pathway of the Complement System

Viruses, 2021
Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4).
Romchat Kraivong, Nuntaya Punyadee, M. Kathryn Liszewski, John P. Atkinson, Panisadee Avirutnan   +4 more
doaj   +1 more source

Mannan-binding lectin and hepatitis C infection [PDF]

Clinical and Experimental Immunology, 2003
SUMMARY Japanese patients with chronic hepatitis C infection unresponsive to treatment with interferon possessed genotypes disproportionately conferring low mannan-binding lectin (MBL) concentrations. Our aims were to confirm or refute this finding in European patients at the MBL protein level, and to investigate whether a low ...
Kilpatrick, D.C., Delahooke, T.E., Koch, C., Turner, M.L., Hayes, P.C.   +4 more
openaire   +4 more sources

Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway–mediated disorders

Frontiers in Immunology, 2023
IntroductionOveractivation of the lectin pathway of complement plays a pathogenic role in a broad range of immune-mediated and inflammatory disorders; mannan-binding lectin-associated serine protease-2 (MASP-2) is the key effector enzyme of the lectin ...
Thomas Dudler, Sadam Yaseen, W. Jason Cummings   +2 more
doaj   +1 more source

Letter to the Editor: LO2, a misidentified cell line: Some data should be interpreted with caution

, 2022
Hepatology, EarlyView.
Ralf Weiskirchen
wiley   +1 more source

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +1 more source