Results 21 to 30 of about 44,027 (268)

High normal TSH is associated with lower mannan-binding lectin in women of childbearing age. [PDF]

BMC Endocr Disord, 2020
BackgroundMannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Lower MBL levels are associated with, among other conditions, hypothyroidism and adverse pregnancy outcomes. In turn, adverse pregnancy outcomes and
Karbownik-Lewinska M, Stepniak J, Marcinkowska M, Krygier A, Lewinski A.   +4 more
europepmc   +2 more sources

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +6 more sources

A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs). [PDF]

Stem Cell Rev Rep, 2020
Delayed homing and engraftment of hematopoietic stem progenitor cells (HSPCs) or even failure to engraft at all is significant clinical problem after hematopoietic transplant.
Adamiak M, Cymer M, Anusz K, Tracz M, Ratajczak MZ.   +4 more
europepmc   +2 more sources

Direct Blood Culturing of Candida spp. on Solid Medium by a Rapid Enrichment Method with Magnetic Beads Coated with Recombinant Human Mannan-Binding Lectin. [PDF]

J Clin Microbiol, 2020
A rapid and accurate method to identify the species and antibiotic resistance of Candida spp. in blood is vital to increase the survival rates of patients with bloodstream infections. However, the extremely low levels of Candida spp.
Chen XL, Zheng H, Li WG, Zhong YH, Chen XP, Lu JX.   +5 more
europepmc   +2 more sources

Targeting of Liver Mannan-Binding Lectin-Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis. [PDF]

Immunohorizons, 2018
Mannan-binding lectin–associated serine protease 3 (MASP-3) regulates the alternative pathway of complement and is predominantly synthesized in the liver. The role of liver-derived MASP-3 in the pathogenesis of rheumatoid arthritis (RA) is unknown.
Banda NK, Desai D, Scheinman RI, Pihl R, Sekine H, Fujita T, Sharma V, Hansen AG, Garred P, Thiel S, Borodovsky A, Holers VM.   +11 more
europepmc   +2 more sources

A novel bifunctional hybrid with marine bacterium alkaline phosphatase and Far Eastern holothurian mannan-binding lectin activities. [PDF]

PLoS ONE, 2014
A fusion between the genes encoding the marine bacterium Cobetia marina alkaline phosphatase (CmAP) and Far Eastern holothurian Apostichopus japonicus mannan-binding C-type lectin (MBL-AJ) was performed. Expression of the fusion gene in E.
Larissa Balabanova, Vasily Golotin, Svetlana Kovalchuk, Alexander Bulgakov, Galina Likhatskaya, Oksana Son, Valery Rasskazov   +6 more
doaj   +2 more sources

Mannan-binding lectin suppresses growth of hepatocellular carcinoma by regulating hepatic stellate cell activation via the ERK/COX-2/PGE₂ pathway. [PDF]

Oncoimmunology, 2019
Mannan binding lectin (MBL), initially known to activate the complement lectin pathway and defend against infection, was recently shown to be potentially involved in the development of several types of cancer; however, its exact role in cancers ...
Li J, Li H, Yu Y, Liu Y, Liu Y, Ma Q, Zhang L, Lu X, Wang XY, Chen Z, Zuo D, Zhou J.   +11 more
europepmc   +2 more sources

Substitution of Mannan-Binding Lectin (MBL)-Deficient Serum With Recombinant MBL Results in the Formation of New MBL/MBL-Associated Serine Protease Complexes. [PDF]

Front Immunol, 2018
The lectin pathway (LP) of complement activation depends on the activation of the MBL-associated serine proteases (MASPs) circulating in complex with mannan-binding lectin (MBL).
Keizer MP, Kamp A, van Mierlo G, Kuijpers TW, Wouters D.   +4 more
europepmc   +2 more sources

Mannan binding lectin triggers mobilization of hematopoietic stem cells. [PDF]

Oncotarget, 2017
Mounting evidence has accumulated that mobilization of hematopoietic stem progenitor cells (HSPCs) from the bone marrow (BM) into peripheral blood (PB) is a part of the developmentally ancient inborn innate immunity response to i) systemic or local ...
Adamiak M, Abdel-Latif A, Ratajczak MZ.
europepmc   +2 more sources

Serum mannan-binding lectin in patients with pulmonary tuberculosis: Its lack of a relationship to the disease and response to treatment. [PDF]

Med J Islam Repub Iran, 2017
Background: Lectin pathway mediates complement activation, which is activated by many microorganisms. This study aimed at determining the serum levels of mannose-binding lectin (MBL) in patients with pulmonary tuberculosis, assessing its relationship to ...
Ahmadi F, Ghadiri A, NashibI R, Roozbeh F, Alizadeh-Navaei R.   +4 more
europepmc   +2 more sources