Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin. [PDF]
PLoS ONE, 2014 Lysyl hydroxylase 3 (LH3) is a multifunctional protein with lysyl hydroxylase, galactosyltransferase and glucosyltransferase activities. The LH3 has been shown to modify the lysine residues both in collagens and also in some collagenous proteins. In this
Maija Risteli +5 more
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Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1. [PDF]
J Neuroinflammation, 2016 Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of ischemic ...
Orsini F +8 more
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Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes [PDF]
Journal of Diabetes Research, 2017 Objective. Mannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk of diabetic nephropathy.
Gry Høst Dørflinger +4 more
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Therapeutic applications of mannan-binding lectin [PDF]
The Biochemist, 2003 Mannan-binding lectin (MBL) is perhaps the best known of the collectins, a subfamily of C-type lectins possessing an additional collagen-like domain. MBL is thought to be an important component of innate immunity. Since the discovery, around 15 years ago, that MBL was identical to a factor responsible for the opsonization of baker's yeast in vitro, a ...
David C. Kilpatrick
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Clinical manifestations of mannan-binding lectin deficiency
Molecular Immunology, 2005 Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune system.
Steffen Thiel +2 more
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Mannan-Binding Lectin Is Associated with Inflammation and Kidney Damage in a Mouse Model of Type 2 Diabetes. [PDF]
Int J Mol SciDørflinger GH +5 more
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Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. [PDF]
Front ImmunolHymøller KM +5 more
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Recognition of <i>Staphylococcus aureus</i> by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. [PDF]
Front ImmunolHymøller KM +5 more
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Mannan-binding lectin in cardiovascular disease. [PDF]
Biomed Res Int, 2014 Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to
Pągowska-Klimek I, Cedzyński M.
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Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury. [PDF]
J NeuroinflammationMercurio D +12 more
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