Results 31 to 40 of about 14,274 (254)

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

Altered profile of glycosylated proteins in serum samples obtained from patients with Hashimoto′s thyroiditis following depletion of highly abundant proteins

Frontiers in Immunology, 2023
ObjectivesHashimoto’s thyroiditis (HT) is one of the most common autoimmune disorders; however, its underlying pathological mechanisms remain unclear. Although aberrant glycosylation has been implicated in the N-glycome of immunoglobulin G (IgG), changes
Yaozheng Xu, Yaozheng Xu, Jiawen Huo, Jiawen Huo, Ruili Nie, Ruili Nie, Lili Ge, Lili Ge, Chonghong Xie, Chonghong Xie, Yuan Meng, Yuan Meng, Jianhua Liu, Jianhua Liu, Lina Wu, Lina Wu, Xiaosong Qin, Xiaosong Qin   +17 more
doaj   +1 more source

Cell-surface protein YwfG of Lactococcus lactis binds to α-1,2-linked mannose.

PLoS ONE, 2023
Lactococcus lactis strains are used as starter cultures in the production of fermented dairy and vegetable foods, but the species also occurs in other niches such as plant material. Lactococcus lactis subsp. lactis G50 (G50) is a plant-derived strain and
Wataru Tsuchiya, Zui Fujimoto, Noritoshi Inagaki, Hiroyuki Nakagawa, Miwa Tanaka, Hiromi Kimoto-Nira, Toshimasa Yamazaki, Chise Suzuki   +7 more
doaj   +2 more sources

Mannan binding lectin: a two-faced regulator of renal allograft injury? [PDF]

Kidney International, 2013
Complement activation plays an important role in the pathogenesis of renal allograft injury after kidney transplantation. There are three known pathways of complement activation, namely, classical, alternative, and lectin pathways. In renal allograft injury, contradictory results were reported about the role of the lectin pathway activated via mannan ...
Damman, Jeffrey, Seelen, Marc A.
openaire   +3 more sources

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble, Brodsky-Doyle, Chen, Chen, Christopher Furze, Daniel A. Mitchell, Doliana, Emsley, Fan, Feinberg, Girija, Haurum, Heise, Hohenester, Hoppe, Jensenius, Julia Toth, Kaufman, Kurata, Phillips, Porter, Reid, Reid, Reid, Russell Wallis, Scherer, Shoulders, Sim, Strang, Teillet, Uemura, Umakhanth Venkatraman Girija, Wallis, Wallis, Wallis, Wallis, Wallis, Wallis, Wilhelm J. Schwaeble   +38 more
core   +2 more sources

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

Frontiers in Immunology, 2023
IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus.
Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Federica Mescia, Laura Bergamaschi, Laura Bergamaschi, Blanka Mező, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Paul A. Lyons, Paul A. Lyons, Erik J. M. Toonen, Zoltán Prohászka, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Paul A. Lyons, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Laura Bergamaschi, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Federica Mescia, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova   +174 more
doaj   +1 more source

Proteins of the Lectin Pathway of complement activation at the site of injury in subarachnoid hemorrhage compared with peripheral blood

Brain and Behavior, 2020
Background A subarachnoid hemorrhage (SAH) is a debilitating stroke. Activation of the lectin pathway (LP) of the complement system in SAH patients could worsen the prognosis; however, conflicting results have been reported.
Thorkil Anker‐Møller, Anne‐Mette Hvas, Niels Sunde, Steffen Thiel, Anne Troldborg   +4 more
doaj   +1 more source

Characterization of a Novel Mannose-Binding Lectin with Antiviral Activities from Red Alga, Grateloupia chiangii

Biomolecules, 2020
Lectins have the ability to bind specific carbohydrates and they have potential applications as medical and pharmacological agents. The unique structure and usefulness of red algal lectin have been reported, but these lectins are limited to a few marine ...
Hyun-Ju Hwang, Jin-Wook Han, Hancheol Jeon, Kichul Cho, Ju-hee Kim, Dae-Sung Lee, Jong Won Han   +6 more
doaj   +1 more source

Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis

Renal Failure, 2022
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima, Dan Inoue, Takeaki Wajima, Takahiro Uchida, Muneharu Yamada, Isao Ohsawa, Takashi Oda   +6 more
doaj   +1 more source

Mannan binding lectin deficiency and concomitant immunodefects [PDF]

Archives of Disease in Childhood, 1998
To determine the prevalence of a mannan binding lectin (MBL) deficiency in children with increased susceptibility to infections and to investigate whether other coexisting immunodeficiencies affecting opsonisation are needed to render MBL deficiency clinically significant.343 serum samples were collected from 266 children with repeated infections, a ...
J, Aittoniemi, M, Baer, E, Soppi, T, Vesikari, A, Miettinen   +4 more
openaire   +2 more sources