Results 31 to 40 of about 6,162 (208)

Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury. [PDF]

J Neuroinflammation
Mercurio D, Pischiutta F, Seminara S, Tribuzio F, Lisi I, Pasetto L, Bonetto V, De Simoni MG, Schwaeble W, Yaseen S, Dudler T, Zanier ER, Fumagalli S.   +12 more
europepmc   +2 more sources

3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors

Frontiers in Molecular Biosciences, 2021
Humans and other mammals resist exogenous pathogens by recognizing them as non-self. How do they do this? The answer lies in the recognition by mammalian lectin receptors of glycans usually found on the surface of pathogens and whose chemical structure ...
Noriyoshi Manabe, Yoshiki Yamaguchi
doaj   +1 more source

A novel bifunctional hybrid with marine bacterium alkaline phosphatase and Far Eastern holothurian mannan-binding lectin activities. [PDF]

PLoS ONE, 2014
A fusion between the genes encoding the marine bacterium Cobetia marina alkaline phosphatase (CmAP) and Far Eastern holothurian Apostichopus japonicus mannan-binding C-type lectin (MBL-AJ) was performed. Expression of the fusion gene in E.
Larissa Balabanova, Vasily Golotin, Svetlana Kovalchuk, Alexander Bulgakov, Galina Likhatskaya, Oksana Son, Valery Rasskazov   +6 more
doaj   +1 more source

Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis [PDF]

Infection and Immunity, 2001
ABSTRACTLevels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonizedLeishmania chagasipromastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites.
Isabel Kinney Ferreira de Miranda Santos, Carlos Henrique Nery Costa, Henrique Krieger, Mary F. Feitosa, David Zurakowski, Babak Fardin, Régis Gomes, Debra L. Weiner, Donald A. Harn, R. Alan B. Ezekowitz, Judith E. Epstein   +10 more
openalex   +4 more sources

Mannan-binding lectin and hepatitis C infection [PDF]

Clinical and Experimental Immunology, 2003
SUMMARY Japanese patients with chronic hepatitis C infection unresponsive to treatment with interferon possessed genotypes disproportionately conferring low mannan-binding lectin (MBL) concentrations. Our aims were to confirm or refute this finding in European patients at the MBL protein level, and to investigate whether a low ...
Kilpatrick, D.C., Delahooke, T.E., Koch, C., Turner, M.L., Hayes, P.C.   +4 more
openaire   +4 more sources

Proteins of the Lectin Pathway of complement activation at the site of injury in subarachnoid hemorrhage compared with peripheral blood

Brain and Behavior, 2020
Background A subarachnoid hemorrhage (SAH) is a debilitating stroke. Activation of the lectin pathway (LP) of the complement system in SAH patients could worsen the prognosis; however, conflicting results have been reported.
Thorkil Anker‐Møller, Anne‐Mette Hvas, Niels Sunde, Steffen Thiel, Anne Troldborg   +4 more
doaj   +1 more source

Tackling the Legs of Mannan-Binding Lectin [PDF]

Structure, 2011
The recognition of pathogen surfaces by mannan-binding lectin activates MASP proteases, leading to complement activation. A crystal structure by Gingras et al. (2011) in this issue of Structure now shows how the collagen-like stems of mannan-binding lectin bind MASP-1 through a minimalist set of interactions.
openaire   +3 more sources

The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models

Frontiers in Immunology, 2018
The injection of mannan into mice can result in the development of psoriasis (Ps) and psoriatic arthritis (PsA), whereas co-injection with antibodies toward collagen type II leads to a chronic rheumatoid-like arthritis.
Cecilia Hagert, Cecilia Hagert, Outi Sareila, Outi Sareila, Tiina Kelkka, Tiina Kelkka, Sirpa Jalkanen, Rikard Holmdahl, Rikard Holmdahl   +8 more
doaj   +1 more source

Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls.

PLoS Pathogens, 2020
During the course of fungal infection, pathogen recognition by the innate immune system is critical to initiate efficient protective immune responses. The primary event that triggers immune responses is the binding of Pattern Recognition Receptors (PRRs),
Ingrida Vendele, Janet A Willment, Lisete M Silva, Angelina S Palma, Wengang Chai, Yan Liu, Ten Feizi, Maria Spyrou, Mark H T Stappers, Gordon D Brown, Neil A R Gow   +10 more
doaj   +1 more source

Mannan binding lectin deficiency and concomitant immunodefects [PDF]

Archives of Disease in Childhood, 1998
To determine the prevalence of a mannan binding lectin (MBL) deficiency in children with increased susceptibility to infections and to investigate whether other coexisting immunodeficiencies affecting opsonisation are needed to render MBL deficiency clinically significant.343 serum samples were collected from 266 children with repeated infections, a ...
Baer M, Timo Vesikari, A Miettinen, E Soppi, Janne Aittoniemi   +4 more
openaire   +3 more sources