Results 41 to 50 of about 13,265 (210)

Serum MASP-1 in complex with MBL activates endothelial cells. [PDF]

, 2014
The complement system plays an important role in the induction of inflammation. In this study we demonstrate that the initiation complexes of the lectin pathway, consisting of mannose-binding lectin (MBL) and associated serine proteases (MASPs) elicit ...
Ambrus, Balázs Major, Beinrohr, Dahl, Davis, Degn, Degn, Degn, Degn, Dobó, Dobó, Dobó, Endre Schwaner, Erika Kajdácsi, Gulla, Gál, Hansen, Heja, Heja, Hess, Jensenius, János Rigó, József Dobó, Kidmose, Kocsis, László Cervenak, Matsushita, Matsushita, Matsushita, Megyeri, Megyeri, Márton Megyeri, Møller-Kristensen, Oroszlán, Paréj, Paréj, Péter Gál, Péter K. Jani, Péter Závodszky, Ricklin, Saeed, Skjoedt, Steffen Thiel, Stover, Takahashi, Thiel, Thiel, Thiel, Thiel, Thiel, van der Pol   +50 more
core   +1 more source

Mannan‐Binding Lectin Inhibits Humoural Responses [PDF]

Scandinavian Journal of Immunology, 2004
Chronic hepatitis B virus (HBV) infection affects about 200–400 million people worldwide and represents one of the leading causes for liver cirrhosis and hepatocellular carcinoma. Control over the HBV infection is achieved mainly by vaccination with Hepatitis B surface antigen (HBsAg).
M. Ruseva, M. Gajdeva, K. Takahashi, A. Ezekowitz, S. Thiel, J. C. Jensenius   +5 more
openaire   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes. [PDF]

PLoS ONE, 2017
Deficiency of glucocerebrosidase (GBA) causes Gaucher disease (GD). In the common non-neuronopathic GD type I variant, glucosylceramide accumulates primarily in the lysosomes of visceral macrophages.
Wouter W Kallemeijn, Saskia Scheij, Sascha Hoogendoorn, Martin D Witte, Daniela Herrera Moro Chao, Cindy P A A van Roomen, Roelof Ottenhoff, Herman S Overkleeft, Rolf G Boot, Johannes M F G Aerts   +9 more
doaj   +1 more source

Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors [PDF]

, 2013
Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to ...
A Hurtado-Lorenzo, A Nanbo, A Puig-Kroger, A Sanchez, A Takada, A Takada, A Takada, A Yonezawa, AB Boldt, AD Hyatt, AG Bowie, AL Brass, Alan B. Ezekowitz, AM Kerrigan, Amel Omari, Anna Sokolovska, AS Kondratowicz, AS Powlesland, Ashish Sarraju, B Ghebrehiwet, BJ Shiell, BM Gunn, Bradley S. Schneider, Bruce A. Mungall, BT Rouse, CA Blanchong, CA Zampieri, Calli Lear, CD Collard, CF Spiropoulou, CL Hood, CL Hunt, Corinne Scully, CP Alvarez, D Dube, D Dube, Damon P. Eisen, Darrell N. Kotton, DJ Vigerust, DL Jack, DM Tobin, E Matei, E McGreal, E Mehlhop, Emmett V. Schmidt, G Catano, Gene G. Olinger, Gregory L. Stahl, Gregory T. Spear, H Feldmann, H Feldmann, H Zhang, HO Madsen, I-Chueh Huang, Ian C. Michelow, IC Michelow, IC Michelow, IJ de Messias-Reason, J Mercer, J Mercer, J Moffat, J Seyfarth, J Seyfarth, JE Lee, JH Kuhn, JL Casanova, JM Rojek, JR Francica, JS Towner, JT Denholm, K Chandran, K Li, K Quinn, K Saxena, K Schornberg, K Takahashi, Kazue Takahashi, L Kainulainen, L Xu, L. Michael Yantosca, LD Powell, LG Barrientos, Li Chen, Lynda Stuart, M Cote, M Dong, M Shimojima, M Super, M. Reza Zariffard, Marshall Karpel, Matthew Brudner, MC Pickering, MF Medina, MF Saeed, Michael Farzan, MS Maginnis, MT Ling, N Bayer, NJ Klein, O Dolnik, O Reynard, P Garred, P Phanuphak, R Pagh, R Steffensen, RA Ezekowitz, RA Hawkes, RL Kaletsky, RR Nepomuceno, S Bhattacharyya, S Thiel, S Thiel, S Thiel, SB Halstead, SJ Gardai, SL Hanna, T Bernig, T Vorup-Jensen, WA Williamson, WB Oswald, WJ Schwaeble, WK Ip, WK Ip, X Ji, Y Yang, YL Wu   +125 more
core   +9 more sources

The salivary scavenger and agglutinin (SALSA) binds MBL and regulates the lectin pathway of complement in solution and on surfaces

Frontiers in Immunology, 2012
The scavenger receptor cysteine-rich (SRCR) protein SALSA, also known as gp340, salivary agglutinin (SAG) and deleted in malignant brain tumor 1 (DMBT1), is a 340 kDa glycoprotein expressed on mucosal surfaces and secreted into several body fluids. SALSA
Martin eParnov Reichhardt, Vuokko eLoimaranta, Steffen eThiel, Jukka eFinne, Seppo eMeri, Seppo eMeri, Hanna eJarva, Hanna eJarva   +7 more
doaj   +1 more source

High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes

Frontiers in Immunology, 2022
IntroductionAccumulating evidence support that mannan-binding lectin (MBL) is a promising prognostic biomarker for risk-stratification of diabetic micro- and macrovascular complications.
G. H. Dørflinger, G. H. Dørflinger, P. H. Høyem, E. Laugesen, J. A. Østergaard, J. A. Østergaard, K. L. Funck, K. L. Funck, R. Steffensen, P. L. Poulsen, P. L. Poulsen, T. K. Hansen, M. Bjerre   +12 more
doaj   +1 more source

Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]

, 2016
AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke, B Ferwerda, BN Gantner, C Kuei, CA Johnston, CA Munro, CA Rappleye, CJ Barelle, CJ Heilmann, DH Owen, DO Inglis, E Leberer, FN Gravelat, G Bindea, GD Brown, GJ Sosinska, HJ Flint, I Jacobs, ID Iliev, IV Ene, IV Ene, IV Ene, IV Ene, JE Nett, JM Bain, K Lemaire, LE Lewis, LM Graham, M Galán-Díez, M Karababa, M Santos, MG Netea, MG Netea, MJ Marakalala, MM Maidan, MT Kelly, N Vieira, NAR Gow, P Shannon, PR Desai, RA Hall, RT Wheeler, RT Wheeler, RT Wheeler, S Lev, S Shahana, SdJ Carrion, SE Hardison, SM Noble, TR O'Meara, YL Chen   +50 more
core   +1 more source

Tackling the Legs of Mannan-Binding Lectin [PDF]

Structure, 2011
The recognition of pathogen surfaces by mannan-binding lectin activates MASP proteases, leading to complement activation. A crystal structure by Gingras et al. (2011) in this issue of Structure now shows how the collagen-like stems of mannan-binding lectin bind MASP-1 through a minimalist set of interactions.
openaire   +2 more sources

Nanoparticle‐Based Tolerogenic Vaccines: Next‐Generation Strategies for Autoimmune and Allergic Disease Therapies

Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.
Nanoparticle‐based tolerogenic vaccines harness controlled antigen delivery and immunomodulation to establish tolerance in autoimmunity and allergy. This review outlines how nanoparticle design (size, shape, composition, administration route) influences biodistribution and immune‐cell targeting.
Benjamin E. Nachod, Ajay S. Thatte, Rohan Palanki, Michael J. Mitchell   +3 more
wiley   +2 more sources