Results 41 to 50 of about 6,162 (208)

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes. [PDF]

PLoS ONE, 2017
Deficiency of glucocerebrosidase (GBA) causes Gaucher disease (GD). In the common non-neuronopathic GD type I variant, glucosylceramide accumulates primarily in the lysosomes of visceral macrophages.
Wouter W Kallemeijn, Saskia Scheij, Sascha Hoogendoorn, Martin D Witte, Daniela Herrera Moro Chao, Cindy P A A van Roomen, Roelof Ottenhoff, Herman S Overkleeft, Rolf G Boot, Johannes M F G Aerts   +9 more
doaj   +1 more source

The salivary scavenger and agglutinin (SALSA) binds MBL and regulates the lectin pathway of complement in solution and on surfaces

Frontiers in Immunology, 2012
The scavenger receptor cysteine-rich (SRCR) protein SALSA, also known as gp340, salivary agglutinin (SAG) and deleted in malignant brain tumor 1 (DMBT1), is a 340 kDa glycoprotein expressed on mucosal surfaces and secreted into several body fluids. SALSA
Martin eParnov Reichhardt, Vuokko eLoimaranta, Steffen eThiel, Jukka eFinne, Seppo eMeri, Seppo eMeri, Hanna eJarva, Hanna eJarva   +7 more
doaj   +1 more source

High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes

Frontiers in Immunology, 2022
IntroductionAccumulating evidence support that mannan-binding lectin (MBL) is a promising prognostic biomarker for risk-stratification of diabetic micro- and macrovascular complications.
G. H. Dørflinger, G. H. Dørflinger, P. H. Høyem, E. Laugesen, J. A. Østergaard, J. A. Østergaard, K. L. Funck, K. L. Funck, R. Steffensen, P. L. Poulsen, P. L. Poulsen, T. K. Hansen, M. Bjerre   +12 more
doaj   +1 more source

Hormonal regulation of mannan-binding lectin synthesis in hepatocytes [PDF]

Clinical and Experimental Immunology, 2006
SummaryActivation of the complement system via the plasma protein mannan-binding lectin (MBL) provides a first line of defence against infections. The plasma level of MBL is, in part, determined genetically, but may also be influenced by different hormones in vivo.
Sørensen, C M, Hansen, T K, Steffensen, R, Jensenius, Jens Christian, Thiel, S   +4 more
openaire   +4 more sources

Thyroid hormone increases mannan-binding lectin levels [PDF]

European Journal of Endocrinology, 2005
Background: Recent studies have indicated the existence of causal links between the endocrine and immune systems and cardiovascular disease. Mannan-binding lectin (MBL), a protein of the innate immune system, may constitute a connection between these fields.
Riis, Anne Lene Dalkjaer, Hansen, Troels Krarup, Thiel, Steffen, Gravholt, Claus Højbjerg, Gjedde, Signe, Gormsen, Lars Christian, Jørgensen, Jens Otto Lunde, Weeke, Jørgen, Møller, Niels   +8 more
openaire   +4 more sources

Synthesis of Rhamnose‐Modified Lewis‐X‐Containing Saponins

European Journal of Organic Chemistry, EarlyView.
The synthesis of triterpenoid saponins bearing a Lewis‐X trisaccharide analogue, in which the fucose residue is replaced by a rhamnose, is presented. These saponins, designed as negative controls in dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing nonintegrin‐targeted therapeutic applications, are prepared through iterative and ...
Oscar Javier Gamboa Marin, Nitish Verma, Maude Cloutier, Charles Gauthier   +3 more
wiley   +1 more source

Lewis‐X‐Containing Triterpenoid Saponins Inhibit DC‐SIGN‐ and L‐SIGN‐Mediated Transfer of HIV‐1 Infection

Chemistry – A European Journal, Volume 31, Issue 32, June 6, 2025.
The convergent synthesis of Lewis‐X‐containing betulinic acid and echinocystic acid saponins (1 and 2) is presented. The synthetic saponins were shown to inhibit, at the low micromolar range, the DC‐SIGN‐ and L‐SIGN‐mediated transfer of HIV‐1 infection to CD4‐positive cells, whereas free Lewis‐X, aglycones, and structurally similar triterpenoid ...
Oscar Javier Gamboa Marin, Kurtis Ng, Nitish Verma, Assi Gérard Flavien Yapi, Ralph Pantophlet, Charles Gauthier   +5 more
wiley   +1 more source

Mannan‐Binding Lectin Inhibits Humoural Responses [PDF]

Scandinavian Journal of Immunology, 2004
Chronic hepatitis B virus (HBV) infection affects about 200–400 million people worldwide and represents one of the leading causes for liver cirrhosis and hepatocellular carcinoma. Control over the HBV infection is achieved mainly by vaccination with Hepatitis B surface antigen (HBsAg).
Jens Chr. Jensenius, Marieta M. Ruseva, Alan Ezekowitz, Steffen Thiel, Kazue Takahashi, M. Gajdeva   +5 more
openaire   +2 more sources

Herpes simplex encephalitis in adult patients with MASP-2 deficiency.

PLoS Pathogens, 2019
We report here two cases of Herpes simplex virus encephalitis (HSE) in adult patients with very rare, previously uncharacterized, non synonymous heterozygous G634R and R203W substitution in mannan-binding lectin serine protease 2 (MASP2), a gene encoding
Stéphanie Bibert, Jocelyne Piret, Mathieu Quinodoz, Emilie Collinet, Vincent Zoete, Olivier Michielin, Rafik Menasria, Pascal Meylan, Titus Bihl, Véronique Erard, Florence Fellmann, Carlo Rivolta, Guy Boivin, Pierre-Yves Bochud   +13 more
doaj   +1 more source

Interaction of C1q and Mannan-Binding Lectin with Viruses

Immunobiology, 2002
As soluble recognition molecules of innate immunity, C1q and MBL are able to bind directly to various viruses, including retroviruses and influenza viruses. Interaction of C1q with retroviruses and certain infected cells was shown to involve the globular region of C1q and viral envelope glycoproteins, such as p15E of MuLV, gp41 and gp120 of HIV-1, gp21
Pascale Tacnet-Delorme, Gérard J. Arlaud, Nicole M. Thielens   +2 more
openaire   +3 more sources