Results 51 to 60 of about 14,274 (254)

Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. [PDF]

, 2006
Hepatic sinusoidal endothelial cells are unique among endothelial cells in their ability to internalize and process a diverse range of antigens. DC-SIGNR, a type 2 C-type lectin expressed on liver sinusoids, has been shown to bind with high affinity to ...
Adam Jennings, Alvarez, Appelmelk, Bartosch, Bashirova, Cormier, Cormier, Crispe, David H. Adams, Ebner, Engering, Feinberg, Flint, Gardner, Geijtenbeek, Grant, Guo, Halary, Hsu, Jameson, Jane A. McKeating, Jie Zhang, Klimstra, Knolle, Krutzik, Lalor, Lasala, Lee, Limmer, Lindenbach, Lindenbach, Lozach, Lozach, Lozach, Ludwig, Maeda, Marzi, McCully, Mitchell, Mukhtar, Patricia F. Lalor, Phoebe J. Sun, Pileri, Pohlmann, Pohlmann, Pohlmann, Pohlmann, Puig-Kroger, Relloso, Romani, Seternes, Simmons, Soilleux, Stefan Hubscher, Tassaneetrithep, Trumpfheller, Turville, Wai K. Lai, Wakita, Yang, Zhang, Zhong   +61 more
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High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300 [PDF]

, 2016
To characterize the interaction potential of the human vaginal isolate Lactobacillus plantarum CMPG5300, its genome was mined for genes encoding lectin-like proteins.
Balzarini, Jan, Imholz, Nicole CE, Lebeer, Sarah, Liekens, Sandra, Malik, Shweta, Noppen, Sam, Petrova, Mariya I, Schols, Dominique, Van Damme, Els, Vanderleyden, Jos, Verhoeven, Tine LA   +10 more
core   +1 more source

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes. [PDF]

PLoS ONE, 2017
Deficiency of glucocerebrosidase (GBA) causes Gaucher disease (GD). In the common non-neuronopathic GD type I variant, glucosylceramide accumulates primarily in the lysosomes of visceral macrophages.
Wouter W Kallemeijn, Saskia Scheij, Sascha Hoogendoorn, Martin D Witte, Daniela Herrera Moro Chao, Cindy P A A van Roomen, Roelof Ottenhoff, Herman S Overkleeft, Rolf G Boot, Johannes M F G Aerts   +9 more
doaj   +1 more source

Serum MASP-1 in complex with MBL activates endothelial cells. [PDF]

, 2014
The complement system plays an important role in the induction of inflammation. In this study we demonstrate that the initiation complexes of the lectin pathway, consisting of mannose-binding lectin (MBL) and associated serine proteases (MASPs) elicit ...
Ambrus, Balázs Major, Beinrohr, Dahl, Davis, Degn, Degn, Degn, Degn, Dobó, Dobó, Dobó, Endre Schwaner, Erika Kajdácsi, Gulla, Gál, Hansen, Heja, Heja, Hess, Jensenius, János Rigó, József Dobó, Kidmose, Kocsis, László Cervenak, Matsushita, Matsushita, Matsushita, Megyeri, Megyeri, Márton Megyeri, Møller-Kristensen, Oroszlán, Paréj, Paréj, Péter Gál, Péter K. Jani, Péter Závodszky, Ricklin, Saeed, Skjoedt, Steffen Thiel, Stover, Takahashi, Thiel, Thiel, Thiel, Thiel, Thiel, van der Pol   +50 more
core   +1 more source

The salivary scavenger and agglutinin (SALSA) binds MBL and regulates the lectin pathway of complement in solution and on surfaces

Frontiers in Immunology, 2012
The scavenger receptor cysteine-rich (SRCR) protein SALSA, also known as gp340, salivary agglutinin (SAG) and deleted in malignant brain tumor 1 (DMBT1), is a 340 kDa glycoprotein expressed on mucosal surfaces and secreted into several body fluids. SALSA
Martin eParnov Reichhardt, Vuokko eLoimaranta, Steffen eThiel, Jukka eFinne, Seppo eMeri, Seppo eMeri, Hanna eJarva, Hanna eJarva   +7 more
doaj   +1 more source

High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes

Frontiers in Immunology, 2022
IntroductionAccumulating evidence support that mannan-binding lectin (MBL) is a promising prognostic biomarker for risk-stratification of diabetic micro- and macrovascular complications.
G. H. Dørflinger, G. H. Dørflinger, P. H. Høyem, E. Laugesen, J. A. Østergaard, J. A. Østergaard, K. L. Funck, K. L. Funck, R. Steffensen, P. L. Poulsen, P. L. Poulsen, T. K. Hansen, M. Bjerre   +12 more
doaj   +1 more source

Tackling the Legs of Mannan-Binding Lectin [PDF]

Structure, 2011
The recognition of pathogen surfaces by mannan-binding lectin activates MASP proteases, leading to complement activation. A crystal structure by Gingras et al. (2011) in this issue of Structure now shows how the collagen-like stems of mannan-binding lectin bind MASP-1 through a minimalist set of interactions.
openaire   +2 more sources

Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]

, 2016
AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke, B Ferwerda, BN Gantner, C Kuei, CA Johnston, CA Munro, CA Rappleye, CJ Barelle, CJ Heilmann, DH Owen, DO Inglis, E Leberer, FN Gravelat, G Bindea, GD Brown, GJ Sosinska, HJ Flint, I Jacobs, ID Iliev, IV Ene, IV Ene, IV Ene, IV Ene, JE Nett, JM Bain, K Lemaire, LE Lewis, LM Graham, M Galán-Díez, M Karababa, M Santos, MG Netea, MG Netea, MJ Marakalala, MM Maidan, MT Kelly, N Vieira, NAR Gow, P Shannon, PR Desai, RA Hall, RT Wheeler, RT Wheeler, RT Wheeler, S Lev, S Shahana, SdJ Carrion, SE Hardison, SM Noble, TR O'Meara, YL Chen   +50 more
core   +1 more source

Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection [PDF]

, 2005
Little is known about the innate immune response to severe acute respiratory syndrome (SARS) coronavirus (CoV) infection. Mannose-binding lectin (MBL), a key molecule in innate immunity, functions as an ante-antibody before the specific antibody response.
Chan, EYT, Chow, EY, Ip, WKE, Jensenius, JC, Ka, LA, Kong, EKP, Kwok, HC, Law, HKW, Lim, W, Peiris, JSM, Tso, GHW, Turner, MW, Wong, WHS, Yu, LL, Yuk, FT, Yung, RWH   +15 more
core   +1 more source

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors [PDF]

, 2006
Peer reviewedPublisher ...
Bates, Steven, Bertram, Gwyneth, Brown, Alistair James Petersen, Buurman, Ed T, Collins, Claire, Ferwerda, Gerben, Gijzen, Karlijn, Gow, Neil Andrew Robert, Hobson, Richard Patrick, Hughes, Huw Bleddyn, Jacobs, Liesbeth, Jansen, Trees, Kullberg, Bart Jan, MacCallum, Donna Margaret, McKinnon, Alistair, Munro, Carol Anne, Netea, Mihai G, Odds, Frank Christopher, Torensma, Ruurd, Van der Meer, Jos W.M., Williams, David L.   +20 more
core   +2 more sources