Results 61 to 70 of about 6,257 (206)

MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes. [PDF]

PLoS ONE, 2014
Microbial infection urges prompt intervention by the immune system. The complement cascade and neutrophil granulocytes are the predominant contributors to this immediate anti-microbial action.
Péter K Jani, Erika Kajdácsi, Márton Megyeri, József Dobó, Zoltán Doleschall, Krisztina Futosi, Csaba I Tímár, Attila Mócsai, Veronika Makó, Péter Gál, László Cervenak   +10 more
doaj   +1 more source

Activation of the Complement/Lectin Pathway, Angiopoietin/Tie‐2/VEGF‐System, Cytokines and Chemokines in Different Angioedema Subtypes

European Journal of Immunology, Volume 55, Issue 7, July 2025.
Biomarkers of vascular integrity and inflammatory processes are involved in different types of angioedema, highlighting the potential importance of complement/lectin system interactions with granulocytes in understanding angioedema triggers. The C1s/C1‐INHc‐to‐MASP‐1/C1‐INHc ratio could be used as a diagnostic tool to distinguish C1‐INH‐HAE from other ...
Katharina Marlies Duda, Manuela Gehring, Bettina Wedi   +2 more
wiley   +1 more source

Mannan-Binding Lectin Serum Levels in 593 Healthy Iranian Children and Adults

Iranian Journal of Allergy, Asthma and Immunology, 2014
Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization.
Sara Zahedifard, Elahe Rashidi, Sedigheh Shams, Shiva Saghafi, Mohammadreza Fazlollahi, Azadeh Talebzadeh, Anoushirvan Kazemnejad, Ahmad Soltani, Zahra Pourpak   +8 more
doaj  

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This review discusses the molecular mechanisms through which these compounds inhibit cancer progression, including the induction of reactive oxygen species, inhibition of mitotic kinase and angiogenesis, and suppression of topoisomerase activity. By providing the latest insights on these anti‐tumor agents and their pharmacological actions, our review ...
Ali Ikram, Nasir A. Ibrahim, Muhammad Tayyab Arshad, Abroo Fatima, Ali Asghar Taseer, Mahreen Faqeer Hussain, Zunair Abdullah, Nosiba S. Basher, Muhammed Adem Abdullahi, Ammar AL‐Farga, Mohammed Ali Al‐Duais   +10 more
wiley   +1 more source

Harnessing the Nutritional Value, Therapeutic Applications, and Environmental Impact of Mushrooms

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Mushrooms are highly nutritious, packed with vitamins, minerals, antioxidants, essential amino acids, and bioactive compounds. They offer various health benefits, including boosting immunity, reducing inflammation, and supporting gut and cardiovascular health. Rich in carbohydrates, quality protein, essential fatty acids, and both soluble and insoluble
Solomon Fitsum, Desta Berhe Sbhatu, Gebreselema Gebreyohannes   +2 more
wiley   +1 more source

Seaweed Proteins: Properties, Extraction, Challenges, and Prospects

Journal of Food Science, Volume 90, Issue 7, July 2025.
ABSTRACT The growing global population and increasing demand for sustainable protein sources have intensified interest in seaweed as a viable plant‐based alternative. Seaweed‐derived proteins and peptides are rich in essential amino acids and exhibit promising functional and bioactive properties, making them attractive for food applications.
Sakhi Ghelichi, Charlotte Jacobsen
wiley   +1 more source

Scabies mite peritrophins are potential targets of human host innate immunity. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Pruritic scabies lesions caused by Sarcoptes scabiei burrowing in the stratum corneum of human skin facilitate opportunistic bacterial infections.
Angela Mika, Priscilla Goh, Deborah C Holt, Dave J Kemp, Katja Fischer   +4 more
doaj   +1 more source

Synthesis of Rhamnose‐Modified Lewis‐X‐Containing Saponins

European Journal of Organic Chemistry, Volume 28, Issue 24, June 24, 2025.
The synthesis of triterpenoid saponins bearing a Lewis‐X trisaccharide analogue, in which the fucose residue is replaced by a rhamnose, is presented. These saponins, designed as negative controls in dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing nonintegrin‐targeted therapeutic applications, are prepared through iterative and ...
Oscar Javier Gamboa Marin, Nitish Verma, Maude Cloutier, Charles Gauthier   +3 more
wiley   +1 more source

The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin

Virology Journal, 2011
Background Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses.
Ushirogawa Hiroshi, Tokunaga Hirotoshi, Ohuchi Masanobu   +2 more
doaj   +1 more source

Lewis‐X‐Containing Triterpenoid Saponins Inhibit DC‐SIGN‐ and L‐SIGN‐Mediated Transfer of HIV‐1 Infection

Chemistry – A European Journal, Volume 31, Issue 32, June 6, 2025.
The convergent synthesis of Lewis‐X‐containing betulinic acid and echinocystic acid saponins (1 and 2) is presented. The synthetic saponins were shown to inhibit, at the low micromolar range, the DC‐SIGN‐ and L‐SIGN‐mediated transfer of HIV‐1 infection to CD4‐positive cells, whereas free Lewis‐X, aglycones, and structurally similar triterpenoid ...
Oscar Javier Gamboa Marin, Kurtis Ng, Nitish Verma, Assi Gérard Flavien Yapi, Ralph Pantophlet, Charles Gauthier   +5 more
wiley   +1 more source