Results 61 to 70 of about 6,162 (208)

Activation of complement system by mannan pathway and Mbl2 genotypes in patients with type 2 diabetes and nephropathy

Zdravniški Vestnik, 2014
To add new evidence that complement activation by the mannan (lectin) pathway is involved in the pathogenesis of nephropathy in patients with type 2 diabetes, we collected blood and urine samples from 20 patients with type 2 diabetes and nephropathy and ...
Tjaša Cerar, Draženka Pongrac Barlovič, Anže Zorin, Nadan Gregorič, Vladimir Kotnik   +4 more
doaj  

Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon, Patricia Perez Schmidt, Nicolo Panini, Francesca Caruso, Martina B. Violatto, Naths Grazia Sukubo, Alberto Martinez‐Serra, Charlotte Blanche Ekalle‐Soppo, Annalisa Morelli, Giulia Yuri Moscatiello, Chiara Grasselli, Alessandro Corbelli, Fabio Fiordaliso, Joe Kelk, Laura Petrosilli, Giuseppe d'Orazio, Ruth Mateu Ferrando, Ariadna Verdaguer Ferrer, Cristina Fornaguera, Luigi Lay, Stefano Fumagalli, Sandro Recchia, Marco P. Monopoli, Laura Polito, Paolo Bigini, Giovanni Sitia   +25 more
wiley   +1 more source

Mannan-Binding Lectin Serum Levels in 593 Healthy Iranian Children and Adults

Iranian Journal of Allergy, Asthma and Immunology, 2014
Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization.
Sara Zahedifard, Elahe Rashidi, Sedigheh Shams, Shiva Saghafi, Mohammadreza Fazlollahi, Azadeh Talebzadeh, Anoushirvan Kazemnejad, Ahmad Soltani, Zahra Pourpak   +8 more
doaj  

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia

Advanced Science, Volume 12, Issue 10, March 13, 2025.
Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo   +21 more
wiley   +1 more source

Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis

Arthritis &Rheumatology, Volume 77, Issue 3, Page 298-310, March 2025.
Objective There is a pressing need to understand the pathogenesis of histologic findings and identify the biomarkers for predicting the histologic severity in lupus nephritis (LN). This study aimed to identify the pathogenic signal pathway and elucidate urinary biomarkers for predicting the presence or severity of histologic findings in LN.
Kazuoto Hiramoto, Shuntaro Saito, Hironari Hanaoka, Jun Kikuchi, Hiroyuki Fukui, Akinori Hashiguchi, Katsuya Suzuki, Tsutomu Takeuchi, Yuko Kaneko   +8 more
wiley   +1 more source

Scabies mite peritrophins are potential targets of human host innate immunity. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Pruritic scabies lesions caused by Sarcoptes scabiei burrowing in the stratum corneum of human skin facilitate opportunistic bacterial infections.
Angela Mika, Priscilla Goh, Deborah C Holt, Dave J Kemp, Katja Fischer   +4 more
doaj   +1 more source

Vaginal Prevotella timonensis Bacteria Enhance HIV‐1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets

European Journal of Immunology, Volume 55, Issue 3, March 2025.
The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV‐1 by primary dendritic cells. Virus is internalised into tetraspanin‐rich compartments, which leads to efficient HIV‐1 transmission to target cells. These results provide insight into how microbiota directly affect HIV‐1 uptake thereby altering HIV‐1 ...
Marleen Y. van Smoorenburg, Ester B. M. Remmerswaal, Celia Segui‐Perez, John L. van Hamme, Karin Strijbis, Teunis B. H. Geijtenbeek   +5 more
wiley   +1 more source

The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin

Virology Journal, 2011
Background Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses.
Ushirogawa Hiroshi, Tokunaga Hirotoshi, Ohuchi Masanobu   +2 more
doaj   +1 more source

Two New Kindreds with Complete Factor D Deficiency

European Journal of Immunology, Volume 55, Issue 3, March 2025.
The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life‐threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in ...
Mathilde Puel, Kenza Rwayane, Paula Vieira Martins, Marwa Chbihi, Frédéric Rieux‐Laucat, Jérémie Rosain, Eric Jeziorski, Bertrand Boisson, Jean‐Laurent Casanova, Véronique Frémeaux‐Bacchi, Carine El Sissy   +10 more
wiley   +1 more source

Exosomal‐complement system activation in preeclampsia

Journal of Obstetrics and Gynaecology Research, Volume 51, Issue 3, March 2025.
Abstract Aim Preeclampsia (PE) is a severe pregnancy‐related disorder characterized by hypertension and multi‐organ failure, primarily affecting the maternal vasculature and placenta. The aim of this review is to explain the molecular mechanisms behind PE by investigating the relationship between exosome release and complement activation, which could ...
M. David, N. Maharaj, A. Krishnan
wiley   +1 more source