Results 71 to 80 of about 6,257 (206)

A Novel Pathosystem With the Model Plant Arabidopsis thaliana for Defining the Molecular Basis of Taphrina Infections

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
A Taphrina strain, identified as Taphrina tormentillae, was shown to cause disease symptoms on the genetic model plant Arabidopsis thaliana, from which it was isolated. A genetic approach was used to implicate the known co‐receptor BAK1 in the activation of immune responses by likely PAMPs found in T. tormentillae cell walls.
Agate Auzane, Margaretta Christita, Kai Wang, Timo Sipilä, Sitaram Rajaraman, Gugan Eswaran, Jasmin Kemppinen, Alejandro De La Fuente, Klaas Bouwmeester, Petri Auvinen, Lars Paulin, Jarkko Salojärvi, Maija Sierla, Mikael Broché, Kirk Overmyer   +14 more
wiley   +1 more source

Zoonotic and Anthropophilic Trichophyton mentagrophytes Complex Infection in Human: An Update and Narrative Review

Mycoses, Volume 68, Issue 6, June 2025.
ABSTRACT Background Trichophyton mentagrophytes species complex comprises dermatophytes responsible for common superficial fungal infections affecting keratinised tissues. Recent shifts in taxonomy and increasing antifungal resistance—necessitate an updated understanding of this fungal complex.
Settanan Plangsiri, Roberto Arenas, Teerapong Rattananukrom   +2 more
wiley   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease, Volume 13, Issue 5, May 2025.
This mini‐review summarizes different classes of pattern recognition receptors (PRRs) and the role of their agonizts that have been identified and also outlines the role of PRR ligands as immunostimulatory molecules. Overall, the mini‐review has elaborated on the role of PRRs in the development of therapeutic vaccine adjuvants.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
wiley   +1 more source

Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer

Swiss Medical Weekly, 2011
QUESTIONS UNDER STUDY: Mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are two key components of the lectin-pathway of complement-activation. Information on the potential role of lectin-pathway components in carcinogenesis
UP Fisch, A Hirt, A Simon, H Ozsahin, FK Niggli, LJ Schlapbach, RA Ammann   +6 more
doaj   +1 more source

MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

Frontiers in Immunology, 2020
It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma, Felix Poppelaars, Wendy Dam, Anita H. Meter-Arkema, Romain R. Vivès, Peter Gál, Geert-Jan Boons, Geert-Jan Boons, Pradeep Chopra, Annamaria Naggi, Marc A. Seelen, Stephan P. Berger, Mohamed R. Daha, Coen A. Stegeman, Jacob van den Born, the COMBAT Consortium   +15 more
doaj   +1 more source

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics

The Scientific World Journal, 2013
The innate immune system is evolutionary and ancient and is the pivotal line of the host defense system to protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effector
Ingrid Evans-Osses, Iara de Messias-Reason, Marcel I. Ramirez   +2 more
doaj   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis ProgressionSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Liver fibrosis represents a hallmark of most chronic liver diseases (CLD) triggered by recurrent liver injury and subsequent myofibroblast transdifferentiations of resident hepatic stellate cells (HSCs). Mannan-binding lectin (MBL)
Jialiang Luo, Lei Li, Bo Chang, Zhengyumeng Zhu, Fan Deng, Mengyao Hu, Yu Yu, Xiao Lu, Zhengliang Chen, Daming Zuo, Jia Zhou   +10 more
doaj  

Mannan-binding lectin is a determinant of survival in infective endocarditis

Clinical and Experimental Immunology, 2007
Summary Mannan-binding lectin (MBL) is a collectin plasma protein activating the lectin pathway of the complement system, enhancing opsonophagocytosis and modulating the cytokine response to inflammation. Deficiency of MBL, caused by structural mutations or promoter polymorphisms in the MBL2 gene, has been associated with increased ...
Tran, C.T., Kjeldsen, Kjeld Elsig, Haunsø, Stig, Høiby, Niels, Johansen, H.K., Christiansen, M.   +5 more
openaire   +4 more sources