Results 71 to 80 of about 6,162 (208)

Mechanisms of immunity in acutely decompensated cirrhosis and acute‐on‐chronic liver failure

Liver International, Volume 45, Issue 3, March 2025.
Abstract The identification of systemic inflammation (SI) as a central player in the orchestration of acute‐on‐chronic liver failure (ACLF) has opened new avenues for the understanding of the pathophysiological mechanisms underlying this disease condition.
Cornelius Engelmann, Ingrid W. Zhang, Joan Clària   +2 more
wiley   +1 more source

The High‐Affinity Chymotrypsin Inhibitor Eglin C Poorly Inhibits Human Chymotrypsin‐Like Protease: Gln192 and Lys218 Are Key Determinants

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 2, Page 543-554, February 2025.
ABSTRACT Eglin C, a small protein from the medicinal leech, has been long considered a general high‐affinity inhibitor of chymotrypsins and elastases. Here, we demonstrate that eglin C inhibits human chymotrypsin‐like protease (CTRL) weaker by several orders of magnitude than other chymotrypsins.
Bálint Zoltán Németh, Bence Kiss, Miklós Sahin‐Tóth, Csaba Magyar, Gábor Pál   +4 more
wiley   +1 more source

Complement anaphylatoxins: Potential therapeutic target for diabetic kidney disease

Diabetic Medicine, Volume 42, Issue 2, February 2025.
Abstract Diabetic kidney disease (DKD) is the most common cause of kidney failure, characterized by chronic inflammation and fibrosis. The complement system is increasingly implicated in the development and progression of diabetic nephropathy. The important complement anaphylatoxins C3a and C5a are key mediators of the innate immune system, which ...
Jingyuan Ma, Wai Han Yiu, Sydney C. W. Tang   +2 more
wiley   +1 more source

Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer

Swiss Medical Weekly, 2011
QUESTIONS UNDER STUDY: Mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are two key components of the lectin-pathway of complement-activation. Information on the potential role of lectin-pathway components in carcinogenesis
UP Fisch, A Hirt, A Simon, H Ozsahin, FK Niggli, LJ Schlapbach, RA Ammann   +6 more
doaj   +1 more source

MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

Frontiers in Immunology, 2020
It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma, Felix Poppelaars, Wendy Dam, Anita H. Meter-Arkema, Romain R. Vivès, Peter Gál, Geert-Jan Boons, Geert-Jan Boons, Pradeep Chopra, Annamaria Naggi, Marc A. Seelen, Stephan P. Berger, Mohamed R. Daha, Coen A. Stegeman, Jacob van den Born, the COMBAT Consortium   +15 more
doaj   +1 more source

Langerhans cells: Central players in the pathophysiology of atopic dermatitis

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 2, Page 278-289, February 2025.
Langerhans cells (LCs) have unique properties to maintain cutaneous immunity. In atopic dermatitis (AD), LCs contribute to a variety of pathophysiological mechanisms underlying AD, such as immune response modulation, microbiome sensing, skin barrier integrity and neuro‐immune communication.
Yi Pan, Mathias Hochgerner, Małgorzata Anna Cichoń, Theresa Benezeder, Thomas Bieber, Peter Wolf   +5 more
wiley   +1 more source

The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics

The Scientific World Journal, 2013
The innate immune system is evolutionary and ancient and is the pivotal line of the host defense system to protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effector
Ingrid Evans-Osses, Iara de Messias-Reason, Marcel I. Ramirez   +2 more
doaj   +1 more source

Nutritional, Nutraceutical, and Medicinal Potential of Cantharellus cibarius Fr.: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
This review explores the nutritional, nutraceutical, and medicinal potential of Cantharellus cibarius, known as the “Golden chanterelle.” Emphasizing its rich composition of bioactive compounds and wide range of health benefits, the review also covers ecological significance, preservation strategies, and potential applications in dietary supplements ...
Ajay Kumar, Reema Devi, Rajni Dhalaria, Ashwani Tapwal, Rachna Verma, Summya Rashid, Gehan M. Elossaily, Khalid Ali Khan, Kow‐Tong Chen, Tarun Verma   +9 more
wiley   +1 more source

Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis ProgressionSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Liver fibrosis represents a hallmark of most chronic liver diseases (CLD) triggered by recurrent liver injury and subsequent myofibroblast transdifferentiations of resident hepatic stellate cells (HSCs). Mannan-binding lectin (MBL)
Jialiang Luo, Lei Li, Bo Chang, Zhengyumeng Zhu, Fan Deng, Mengyao Hu, Yu Yu, Xiao Lu, Zhengliang Chen, Daming Zuo, Jia Zhou   +10 more
doaj  

Mannan-binding lectin is a determinant of survival in infective endocarditis

Clinical and Experimental Immunology, 2007
Summary Mannan-binding lectin (MBL) is a collectin plasma protein activating the lectin pathway of the complement system, enhancing opsonophagocytosis and modulating the cytokine response to inflammation. Deficiency of MBL, caused by structural mutations or promoter polymorphisms in the MBL2 gene, has been associated with increased ...
Tran, C.T., Kjeldsen, Kjeld Elsig, Haunsø, Stig, Høiby, Niels, Johansen, H.K., Christiansen, M.   +5 more
openaire   +4 more sources