Results 151 to 160 of about 41,940 (203)
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Mannose-binding lectin deficiency—revisited
Molecular Immunology, 2003There is an emerging interest for mannose-binding lectin (MBL) due to its role in innate immunity. In this survey we present a mixture of old and new data describing the effect MBL polymorphisms may have on the level and function of the molecule. Three single nucleotide substitutions in exon 1 of the mbl2 gene cause a dominant decrease of functional ...
Garred, I. +3 more
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Mannose‐binding lectin and innate immunity
Immunological Reviews, 2009Summary: Innate immunity is the earliest response to invading microbes and acts to contain infection in the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal expansion of cells that emerge days after antigenic challenge, the innate immune response is immediate.
W K Eddie, Ip +3 more
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Mannose binding lectin (MBL) and HIV
Molecular Immunology, 2005The envelope protein (gp120/gp41) of HIV-1 is highly glycosylated with about half of the molecular mass of gp120 consisting of N-linked carbohydrates. While glycosylation of HIV gp120/gp41 provides a formidable barrier for development of strong antibody responses to the virus, it also provides a potential site of attack by the innate immune system ...
Xin, Ji, Henry, Gewurz, Gregory T, Spear
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Mannose-binding lectin levels in endometriosis
Fertility and Sterility, 2010The serum concentrations of mannose-binding lectin in patients with or without endometriosis do not differ. Mannose-binding lectin could be involved in the modulation of inflammatory responses, but it does not seem to take part in endometriosis pathogenesis.
ORAL, HALUK BARBAROS +2 more
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Cardiovascular Diseases and Mannose-Binding Lectin
Kardiologiia, 2014The role of innate immunity factors in the pathogens of ACS is not well studied, although there is evidence in the literature about their impact on the course of cardiovascular diseases. Mannose-binding lectin (MBL)--one of the key factors of the humoral innate immune system that activates one of complement activation pathways.
I E, Losin +3 more
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Ureaplasma urealyticum binds mannose-binding lectin
Experimental and Molecular Pathology, 2004Mannose-binding C-type lectin (MBL) is an important component of innate immunity in mammals. Mannose-binding lectin (MBL), an acute phase protein, acts as an opsonin for phagocytosis and also activates the mannan-binding lectin complement pathway. It may play a particularly significant role during infancy before adequate specific protection can be ...
Barbara D, Benstein +3 more
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Mannose‐binding lectin and vulvovaginal candidiasis
International Journal of Gynecology & Obstetrics, 2005AbstractObjective: To investigate the effect of mannose‐binding lectin (MBL) gene polymorphism on the immune system and the significance of vaginal MBL concentration in the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (rVVC). Patients and methods: Mannose‐binding lectin concentrations in CVL samples from 111 women were collected ...
Fei, Liu, Qinping, Liao, Zhaohui, Liu
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Mannose binding lectin gene polymorphisms and asthma
Clinical & Experimental Allergy, 2007SummaryBackground Bronchial asthma is a chronic inflammatory disorder of the airways. Recently, it has been suggested that complement plays significant roles in asthma. Mannose‐binding lectin (MBL) is one of the key molecules in complement activation pathways that are associated with several infectious and immune disorders.Subjects and method
X, Wang +5 more
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Anti-microbial activities of mannose-binding lectin
Biochemical Society Transactions, 2003Mannose-binding lectin (MBL; also known as mannan-binding lectin) is involved in first-line defence by binding to bacteria, viruses, protozoa and helminths through a pattern-recognition mode of detection and then initiating a range of host responses. Currently, we have been unable to extrapolate from what we know of the biochemistry of MBL binding to ...
D L, Jack, M W, Turner
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