Results 11 to 20 of about 41,940 (203)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Isolation and partial characterisation of a novel lectin from Aegle marmelos fruit and its effect on adherence and invasion of Shigellae to HT29 cells. [PDF]

PLoS ONE, 2011
Lectins are a class of ubiquitous proteins/glycoproteins that are abundantly found in nature. Lectins have unique carbohydrate binding property and hence have been exploited as drugs against various infectious diseases.
Subramaniya Bharathi Raja, Malliga Raman Murali, Nirmal Kasinathan Kumar, Sivasitambaram Niranjali Devaraj   +3 more
doaj   +1 more source

Mannose‐binding lectin and gastric cancer [PDF]

International Journal of Cancer, 2007
Daniel L. Worthley*, Peter G. Bardy, David L. Gordon and Charles G. Mullighan Department of Gastroenterology and Hepatology, Flinders Medical Centre, South Australia, Australia Division of Hematology, Royal Adelaide Hospital and Institute of Medical and Veterinary Science, South Australia, Australia Department of Hematology–Oncology, The Queen ...
Worthley, D., Bardy, P., Gordon, D., Mullighan, C.   +3 more
openaire   +3 more sources

Mannose-binding lectin levels and major infections in a cohort of very long-term survivors after allogeneic stem cell transplantation

Haematologica, 2010
Background Life-threatening infections are a major cause of death after allogeneic stem cell transplantation. Complement Mannose-binding lectin is a key component of innate immunity.
Michael Osthoff, Alicia Rovó, Martin Stern, Doris Danner, Alois Gratwohl, André Tichelli, Marten Trendelenburg   +6 more
doaj   +1 more source

Mannose binding lectin is required for alphavirus-induced arthritis/myositis. [PDF]

PLoS Pathogens, 2012
Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Bronwyn M Gunn, Thomas E Morrison, Alan C Whitmore, Lance K Blevins, Linda Hueston, Robert J Fraser, Lara J Herrero, Ruben Ramirez, Paul N Smith, Suresh Mahalingam, Mark T Heise   +10 more
doaj   +1 more source

Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis

Revista da Sociedade Brasileira de Medicina Tropical, 2015
INTRODUCTION : We hypothesized higher mannose-binding lectin level and classic factors (i.e., age, sex, alcohol consumption, exposure, and specific treatment) are associated with the severity of periportal fibrosis in schistosomiasis.
Paula Carolina Valença Silva, Adriana Vieira Gomes, Georgea Gertrudes de Oliveira Mendes Cahu, Maria Rosângela Cunha Duarte Coêlho, Maria Tereza Cartaxo Muniz, Ana Lúcia Coutinho Domingues   +5 more
doaj   +1 more source

The ‘involution’ of mannose-binding lectin [PDF]

Human Molecular Genetics, 2005
Mannose-binding lectin (MBL) acts as a serum opsonin in innate immune defense and induces complement activation by the lectin pathway. In humans, low levels of functional serum MBL are caused by the dominant action of three single nucleotide substitutions in exon 1 that disrupt the glycine-rich backbone structure of the protein.
Jeanette, Seyfarth, Peter, Garred, Hans O, Madsen   +2 more
openaire   +2 more sources

Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series

Journal of Medical Case Reports, 2011
Introduction Eosinophilic meningitis, a potentially fatal disease caused by Angiostrongylus cantonensis, is considered an emerging infectious disease.
de Paula-Almeida Olga, Martínez-Alderete René H, Bu-Coifiu-Fanego Raisa, Dorta-Contreras Alberto J, Padilla-Docal Bárbara, Reiber Hansotto, Jensenius Jens   +6 more
doaj   +1 more source

Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties

Marine Drugs, 2019
To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding ...
Annick Barre, Mathias Simplicien, Hervé Benoist, Els J.M. Van Damme, Pierre Rougé   +4 more
doaj   +1 more source

Mannose-Binding Lectin in HIV Infection [PDF]

Future Virology, 2008
Infection with HIV represents a significant global health problem, with high infection rates and high mortality worldwide. Treatment with antiretroviral therapy is inaccessible to many patients and efficacy is limited by development of resistance and side effects.
Sarah, Eisen, Agnieszka, Dzwonek, Nigel J, Klein   +2 more
openaire   +2 more sources