Results 51 to 60 of about 71,841 (307)

Mannose-Binding Lectin and Susceptibility to Schistosomiasis [PDF]

The Journal of Infectious Diseases, 2013
Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as ...
Justin S, Antony, Olusola, Ojurongbe, Hoang, van Tong, Eman Abou, Ouf, Thomas, Engleitner, Akeem A, Akindele, Olawumi R, Sina-Agbaje, Adegboyega O, Adeyeba, Peter G, Kremsner, Thirumalaisamy P, Velavan   +9 more
openaire   +3 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY [PDF]

, 2011
Fc receptors transport maternal antibodies across epithelial cell barriers to passively immunize newborns. FcRY, the functional counterpart of mammalian FcRn (a major histocompatibility complex homolog), transfers IgY across the avian yolk sac, and ...
BENNETT, Bottcher, Burmeister, Dube, East, Kowalczyk, Leach, Linden, Llorca, Martin, Mayer, Mertens, P. J. Bjorkman, Rivera-Calzada, Roopenian, Simister, Simister, Taylor, Tressler, Vaughn, Western, Woof, Y. He   +22 more
core   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]

, 1998
Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Bosbach, R., Brinck, U., Gabius, Hans-Joachim, Korabiowska, M.   +3 more
core   +1 more source

Mannose-binding lectin and meningococcal disease [PDF]

The Lancet, 1999
Ed J. Kuijper, C. A. P. Fijen, Jacob Dankert, Steffen Thiel   +3 more
openalex   +2 more sources

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus [PDF]

, 2009
Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice.
Max Crispin, Veronica T. Chang, David J. Harvey, Raymond A. Dwek, Edward J. Evans, David I. Stuart, E. Yvonne Jones, J. Michael Lord, Robert A. Spooner, Simon J. Davis, Kornfeld, Balaguer, Neusüss, Parodi, Herscovics, Tremblay, Lal, Schachter, Jaeken, Fukuda, Fukuda, Lowe, Green, Paulson, Patnaik, Martinez-Duncker, Hong, Sethuraman, Hoppe, Davis, Davis, Butters, Chang, Stanley, Dwek, Hamilton, Li, Hamilton, Reeves, Gleeson, Hughes, Hughes, Foddy, Paschinger, Aghi, Bebbington, Davis, Aricescu, Durocher, Küster, Börnsen, Harvey, Harvey, Harvey, Harvey, Olsnes, Watson, Spooner, Spooner, Crispin, Crispin, Oh-Eda, Harvey, Domon, Chen, Shah, Moremen, Butler, Choi, Wu, Foulquier   +70 more
core   +2 more sources

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Differential microorganism-induced mannose-binding lectin activation [PDF]

FEMS Immunology & Medical Microbiology, 2003
Mannose-binding lectin (MBL) is a serum complement factor playing a dominant role in first-line defense. When MBL binds to specific sugar moieties on microorganisms, the lectin complement pathway (LCP) is activated. Changes in the mbl gene and promotor may result in MBL with less activity, predisposing the individual to recurrent infections.
Saskia, Kuipers, Piet C, Aerts, Hans, van Dijk   +2 more
openaire   +2 more sources