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The human macrophage mannose receptor is not a professional phagocytic receptor [PDF]
Journal of Leukocyte Biology, 2005 AbstractThe macrophage mannose receptor (MR) appears to play an important role in the binding and phagocytosis of several human pathogens, but its phagocytic property and signaling pathways have been poorly defined. The general strategy to explore such topics is to express the protein of interest in nonphagocytic cells, but in the case of MR, there are
Laurent J. Emorine +4 more
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Mannose receptor-targeted vaccines
Expert Opinion on Biological Therapy, 2004Targeting antigens to endocytic receptors on professional antigen-presenting cells (APCs) represents an attractive strategy to enhance the efficacy of vaccines. Such APC-targeted vaccines have an exceptional ability to guide exogenous protein antigens into vesicles that efficiently process the antigen for major histocompatibility complex class I and ...
Michael W. Fanger +2 more
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Role of the Mannose Receptor in the Immune Response
Current Molecular Medicine, 2001The mannose receptor (MR) recognizes a range of carbohydrates present on the surface and cell walls of micro-organisms. The MR is primarily expressed on macrophages and dendritic cells and is involved in MR-mediated endocytosis and phagocytosis. In addition, the MR plays a key role in host defense and provides a link between innate and adaptive ...
Ian Farquhar Campbell Mckenzie +1 more
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Mannose receptor and phagocytosis
1999Publisher Summary This chapter discusses the role of mannose receptor in phagocytosis. The mannose receptor (MR) is a ≈175 kDa transmembrane receptor expressed on resident macrophage subpopulations, dendritic cells, and on subsets of endothelial cells.
R. Alan B. Ezekowitz, Iain P. Fraser
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Metal ions and human sperm mannose receptors [PDF]
Andrologia, 2000 Zinc and lead concentrations were measured in seminal plasma from fertile donors, infertile men with varicocoele and men undergoing work-ups for in vitro fertilization. Ejaculated spermatozoa from these subjects were incubated in vitro with various metal ions and/or dibromoethane and dibromochloropropane. Mannose receptor expression was correlated with
A. Hershlag +5 more
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Targeting the Mannose Receptor with Mannosylated Subunit Vaccines
Current Medicinal Chemistry, 2014The mannose receptor (MR) is an important component of the immune system and understanding the structural and conformational characteristics of this receptor is a key aspect of vaccine design. Improved understanding of the role of carbohydrate recognition domains 4-7 (CRDs 4-7) in recognising glycosylated ligands present on the surface of pathogens ...
Sedaghat, B., Stephenson, R., Toth, I.
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Ligand recognition by purified human mannose receptor
Archives of Biochemistry and Biophysics, 1992In this work we examine the carbohydrate binding properties of human placental mannose receptor (HMR) using a rapid and sensitive enzyme-linked immunosorbent microplate assay. The assay is based on the inhibition of binding of highly purified receptor to yeast mannan-coated 96-well plates. The specificity of ligand binding was inferred from the potency
Christopher D. Warren +4 more
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The Mannose Receptor in the Brain
2003The mannose receptor is a transmembrane glycoprotein mainly expressed by macrophages, that specifically binds to mannosylated molecules and mediates their endocytosis. Known ligands of the receptor are lysosomases and various pathogens. Ligand specificity and cellular distribution provide the mannose receptor with a very important role in homeostasis ...
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Mannose Receptor and Targeting Strategies
2019The mannose family receptors are unique multidomain, multifunctional endocytic receptors belonging to the C-type lectin family. These receptors, although structurally similar, exhibit differential binding to discrete ligands. This chapter discusses such similarities and differences between the structures, ligands, the expression, and molecular ...
Amit S. Lokhande +3 more
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The Macrophage Mannose Receptor: Current Status
American Journal of Respiratory Cell and Molecular Biology, 1990Sugar-specific recognition of oligosaccharide chains present on macromolecules and particles has emerged as an important mechanism by which macrophages carry out a variety offunctions including host defense, molecular scavenging, and cell-cell recognition.
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