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The mannose 6-phosphate receptor and the biogenesis of lysosomes
Cell, 1988Localization of the 215 kd mannose 6-phosphate receptor (MPR) was studied in normal rat kidney cells. Low levels of receptor were detected in the trans Golgi network, Golgi stack, plasma membrane, and peripheral endosomes. The bulk of the receptor was localized to an acidic, reticular-vesicular structure adjacent to the Golgi complex.
Bernard Hoflack +4 more
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The mannose receptor and other macrophage lectins
Current Biology, 1992The macrophage expresses a variety of cell surface lectins with activities that support specific functional roles and correspond to various differentiation states characteristic of this cell type. Recently, research has been carried out to investigate the mannose receptor, the advanced glycosylation end products receptor, the mannose-6-phosphate ...
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Mannose receptor determination by an ELISA-like method
Journal of Biochemical and Biophysical Methods, 2003Mannose receptor determination may be a useful tool in research, because endocytosis via this animal lectin is involved in many functions of macrophage cells, in particular, the scavenger activity, the specific and unspecific defence against infective diseases, the recognition of neoplastic cells and the activation/differentiation process of the ...
Silvia Musiani, Maria Giulia Battelli
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The mannose receptor and phagocytosis
1992Macrophages are distributed throughout almost all organs in the body where they form a lattice beneath epithelial surfaces; their physiological role includes interactions with neighboring cells, the clotting and complement cascades as well as a role in first line host defense (1).
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Potential role of the mannose receptor in antigen transport
Immunology Letters, 1999Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein.
Siamon Gordon, Luisa Martinez-Pomares
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The mannose receptor is a pattern recognition receptor involved in host defense
Current Opinion in Immunology, 1998The mannose receptor recognizes the patterns of carbohydrates that decorate the surfaces and cell walls of infectious agents. This macrophage and dendritic cell pattern-recognition receptor mediates endocytosis and phagocytosis. The mannose receptor is the prototype of a new family of multilectin receptor proteins (membrane-spanning receptors ...
Philip D. Stahl, R. Alan B. Ezekowitz
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The mannose receptor of macrophages: a current perspective
1985Specific recognition is a hallmark of modern immunology and no area of research activity has generated more enthusiasm than oligosaccharides as mediators of specific recognition. This interest has been nurtured by the belief that oligosaccharides will play some fundamental role in recognition and sorting both at the cellular and molecular level. Indeed,
V. L. Shepherd +2 more
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The Cation-Dependent Mannose 6-Phosphate Receptor
2001The 46kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300kDa cation-independent mannose 6-phosphate receptor (CI-MPR) are the sole members of the P-type family of lectins, which derive their name from their ability to bind phosphorylated mannose residues.
Jung-Ja P. Kim, Nancy M. Dahms
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Structure and Function of the Macrophage Mannose Receptor
2001The mannose receptor acts as a molecular scavenger by mediating Ca2+-dependent recognition and internalization of glycoconjugates terminating in mannose, N-acetylglucosamine or fucose. The receptor was identified when it was found that glycoproteins terminating in GlcNAc or mannose, including lysosomal enzymes, are rapidly cleared from the bloodstream ...
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Purification of the human alveolar macrophage mannose receptor
Biochemical and Biophysical Research Communications, 1987We report here the first isolation of a mannose receptor from human lung, and identify the alveolar macrophage as the cell of origin. The receptor was purified from detergent-solubilized lung tissue by absorption to mannose- and fucose-Sepharose, and elution with EDTA. The eluted protein had a molecular weight of 175 kD.
Jane D. Stephenson +2 more
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