Results 41 to 50 of about 84,098 (261)

The Scavenger Function of Liver Sinusoidal Endothelial Cells in Health and Disease

Frontiers in Physiology, 2021
The aim of this review is to give an outline of the blood clearance function of the liver sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions of hepatic sinusoids in the human liver the LSECs are perfectly located ...
Sabin Bhandari, Anett Kristin Larsen, Peter McCourt, Bård Smedsrød, Karen Kristine Sørensen   +4 more
doaj   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Probing multivalency in ligand–receptor-mediated adhesion of soft, biomimetic interfaces

Beilstein Journal of Organic Chemistry, 2015
Many biological functions at cell level are mediated by the glycocalyx, a dense carbohydrate-presenting layer. In this layer specific interactions between carbohydrate ligands and protein receptors are formed to control cell–cell recognition, cell ...
Stephan Schmidt, Hanqing Wang, Daniel Pussak, Simone Mosca, Laura Hartmann   +4 more
doaj   +1 more source

Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations.

PLoS ONE, 2020
The presence of a high number of macrophages within solid tumors is often significantly associated with poor prognosis and predict treatment failure for chemotherapy and radiotherapy.
Luciana Kovacs, Pablo Cabral, Roger Chammas   +2 more
doaj   +1 more source

Modulation of mannose receptor activity by proteolysis [PDF]

Biochemical Journal, 1990
Macrophages express a receptor on the cell surface that functions to clear glycoproteins from the extracellular milieu. The activity of this receptor is sensitive to treatment with trypsin. In inflammatory situations, macrophages are activated and exposed to increased levels of extracellular proteases.
V L, Shepherd, R, Abdolrasulnia, J, Stephenson, C, Crenshaw   +3 more
openaire   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.

PLoS Pathogens, 2007
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors.
Meimei Shan, Per Johan Klasse, Kaustuv Banerjee, Antu K Dey, Sai Prasad N Iyer, Robert Dionisio, Dustin Charles, Lila Campbell-Gardener, William C Olson, Rogier W Sanders, John P Moore   +10 more
doaj   +1 more source

Binding Properties of the Mannose Receptor

Immunobiology, 2001
A comprehensive approach to the study of mannose receptor (MR) biology has unveiled an unexpected level of complexity and stresses the importance of post-translational modifications and gene regulation in the analysis of protein function. The existence of endogenous tissue ligands for the MR highlights the need to reduce MR expression in antigen ...
L, Martinez-Pomares, S A, Linehan, P R, Taylor, S, Gordon   +3 more
openaire   +2 more sources

Mannose receptor regulation of macrophage cell migration [PDF]

Journal of Leukocyte Biology, 2007
AbstractThe migration of macrophages through peripheral tissues is an essential step in the host response to infection, inflammation, and ischemia as well as in tumor progression and tissue repair. The mannose receptor (MR; CD206, previously known as the macrophage MR) is a 175-kDa type I transmembrane glycoprotein and is a member of a family of four ...
Sturge, Justin, Todd, S. Katrina, Kogianni, Giolanta, McCarthy, Afshan, Isacke, Clare M.   +4 more
openaire   +3 more sources