Results 41 to 50 of about 2,415,950 (382)

Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment

Journal of Experimental Medicine, 2018
The origin and functional specialization of dermal macrophages in cutaneous infections have been little studied. In this paper, we show that a strain of Leishmania major (L.
S. H. Lee, M. Charmoy, A. Romano, A. Paun, M. M. Chaves, F. Cope, D. Ralph, D. Sacks   +7 more
semanticscholar   +1 more source

Mannose receptor regulates motility [PDF]

The Journal of Cell Biology, 2006
![Graphic][1] Myoblasts fail to fuse if they lack the mannose receptor (bottom). If myoblasts are to fuse with nascent myotubes and thus form muscles, they must apparently migrate and chew up extracellular matrix (ECM), according to Jansen and Pavlath (page [403][2 ...
openaire   +2 more sources

Pneumolysin binds to the Mannose-Receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

Nature Microbiology, 2018
Streptococcus pneumoniae (the pneumococcus) is a major cause of mortality and morbidity globally, and the leading cause of death in children under 5 years old.
K. Subramanian, D. R. Neill, H. Malak, Laura Spelmink, Shadia Khandaker, G. Dalla Libera Marchiori, Emma Dearing, A. Kirby, Marie Yang, A. Achour, J. Nilvebrant, P. Nygren, Laura Plant, A. Kadioglu, B. Henriques-Normark   +14 more
semanticscholar   +1 more source

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

PLoS Pathogens, 2008
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus ...
Sigrid E M Heinsbroek, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, Siamon Gordon   +5 more
doaj   +1 more source

Transient Production of Human β-Glucocerebrosidase With Mannosidic-Type N-Glycan Structure in Glycoengineered Nicotiana benthamiana Plants

Frontiers in Plant Science, 2021
Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose
Naphatsamon Uthailak, Hiroyuki Kajiura, Hiroyuki Kajiura, Ryo Misaki, Ryo Misaki, Kazuhito Fujiyama, Kazuhito Fujiyama, Kazuhito Fujiyama   +7 more
doaj   +1 more source

Engineering of GlcNAc-1-phosphotransferase for production of highly phosphorylated lysosomal enzymes for enzyme replacement therapy [PDF]

, 2017
Several lysosomal enzymes currently used for enzyme replacement therapy in patients with lysosomal storage diseases contain very low levels of mannose 6-phosphate, limiting their uptake via mannose 6-phosphate receptors on the surface of the deficient ...
Doray, Balraj, Kornfeld, Stuart, Lee, Wang-Sik, Liu, Lin   +3 more
core   +3 more sources

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation

Journal of Experimental Medicine, 1992
Expression of the macrophage mannose receptor is inhibited by interferon gamma (IFN-gamma), a T helper type 1 (Th-1)-derived lymphokine. Interleukin 4 (IL-4), a Th-2 lymphocyte product, upregulates major histocompatibility class II antigen expression but
M. Stein, S. Keshav, Neil Harris, S. Gordon   +3 more
semanticscholar   +1 more source

Mannose receptor 2 attenuates renal fibrosis. [PDF]

Journal of the American Society of Nephrology, 2012
Mannose receptor 2 (Mrc2) expresses an extracellular fibronectin type II domain that binds to and internalizes collagen, suggesting that it may play a role in modulating renal fibrosis. Here, we found that Mrc2 levels were very low in normal kidneys but subsets of interstitial myofibroblasts and macrophages upregulated Mrc2 after unilateral ureteral ...
J. López-Guisa, Xiaohe Cai, Sarah J. Collins, Ikuyo Yamaguchi, Daryl M. Okamura, T. Bugge, C. Isacke, C. Emson, S. Turner, S. Shankland, A. Eddy   +10 more
semanticscholar   +4 more sources

Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. [PDF]

, 2006
Hepatic sinusoidal endothelial cells are unique among endothelial cells in their ability to internalize and process a diverse range of antigens. DC-SIGNR, a type 2 C-type lectin expressed on liver sinusoids, has been shown to bind with high affinity to ...
Adam Jennings, Alvarez, Appelmelk, Bartosch, Bashirova, Cormier, Cormier, Crispe, David H. Adams, Ebner, Engering, Feinberg, Flint, Gardner, Geijtenbeek, Grant, Guo, Halary, Hsu, Jameson, Jane A. McKeating, Jie Zhang, Klimstra, Knolle, Krutzik, Lalor, Lasala, Lee, Limmer, Lindenbach, Lindenbach, Lozach, Lozach, Lozach, Ludwig, Maeda, Marzi, McCully, Mitchell, Mukhtar, Patricia F. Lalor, Phoebe J. Sun, Pileri, Pohlmann, Pohlmann, Pohlmann, Pohlmann, Puig-Kroger, Relloso, Romani, Seternes, Simmons, Soilleux, Stefan Hubscher, Tassaneetrithep, Trumpfheller, Turville, Wai K. Lai, Wakita, Yang, Zhang, Zhong   +61 more
core   +2 more sources

Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis

Scientific Reports, 2018
Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB).
Yuzo Suzuki, M. Shirai, K. Asada, H. Yasui, M. Karayama, H. Hozumi, K. Furuhashi, N. Enomoto, T. Fujisawa, Y. Nakamura, N. Inui, T. Shirai, H. Hayakawa, T. Suda   +13 more
semanticscholar   +1 more source