Results 61 to 70 of about 288,351 (166)

MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression

Frontiers in Cellular Neuroscience, 2017
The norepinephrine transporter (NET) mediates the clearance of norepinephrine (NE) from the extracellular space and is a target of therapeutic antidepressants and psychostimulants.
Ole V. Mortensen, Mads B. Larsen, Susan G. Amara   +2 more
doaj   +1 more source

The dataset describes: HIF-1 α expression and LPS mediated cytokine production in MKP-1 deficient bone marrow derived murine macrophages

Data in Brief, 2017
The data presented in this article are related to the research article entitled “MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression” (Talwar et al., 2017) [1].
Harvinder Talwar, Christian Bauerfeld, Yusen Liu, Lobelia Samavati   +3 more
doaj   +1 more source

Stress and Vascular Responses: Mitogen-Activated Protein Kinases and Activator Protein-1 as Promising Therapeutic Targets of Vascular Remodeling

Journal of Pharmacological Sciences, 2003
Mitogen-activated protein kinases (MAP kinases), including extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38, play a central role in cellular responses by various stress stimuli such as cell proliferation, apoptosis ...
Shokei Kim, Hiroshi Iwao
doaj   +1 more source

The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2017
Gq is a heterotrimeric G protein that is widely expressed in neurons and regulates neuronal activity. To identify pathways regulating neuronal Gq signaling, we performed a forward genetic screen in Caenorhabditis elegans for suppressors of activated Gq ...
Jill M. Hoyt, Samuel K. Wilson, Madhuri Kasa, Jeremy S. Rise, Irini Topalidou, Michael Ailion   +5 more
doaj   +1 more source

From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors

Molecules, 2017
In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)-N-(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide.
Fabian Heider, Urs Haun, Eva Döring, Mark Kudolo, Catharina Sessler, Wolfgang Albrecht, Stefan Laufer, Pierre Koch   +7 more
doaj   +1 more source

TGFβ₁ activates c-Jun and Erk1 via α_Vβ₆ integrin

Molecular Cancer, 2003
Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins, a family of cell adhesion receptors ...
Schmidt Christian, Luettich Karsta
doaj   +1 more source

Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells

Journal of Pharmacological Sciences, 2009
Many epidemiologic studies have reported that dietary flavonoids provide protection against cardiovascular disease. Quercetin, a member of the bioflavonoids family, has been proposed to have anti-inflammatory, anti-atherogenic, and anti-hypertensive ...
Keisuke Ishizawa, Yuki Izawa-Ishizawa, Sachiyo Ohnishi, Yuki Motobayashi, Kazuyoshi Kawazoe, Shuichi Hamano, Koichiro Tsuchiya, Shuhei Tomita, Kazuo Minakuchi, Toshiaki Tamaki   +9 more
doaj   +1 more source

Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract

Data in Brief, 2017
This data article reports changes in the phosphoproteome and total proteome of cigarette smoke extract (CSE) exposed WT and MAP Kinase Kinase 3 knock out (MKK3−/−) bone marrow derived macrophages (BMDM). The dataset generated is helpful for understanding
Roshni Srivastava, Praveen Mannam, Navin Rauniyar, TuKiet T. Lam, Ruiyan Luo, Patty J. Lee, Anup Srivastava   +6 more
doaj   +1 more source

Dual Specificity Phosphatase 1 Regulates Human Inducible Nitric Oxide Synthase Expression by p38 MAP Kinase

Mediators of Inflammation, 2011
The role of dual specificity phosphatase 1 (DUSP1) in inducible nitric oxide synthase (iNOS) expression in A549 human pulmonary epithelial cells, J774 mouse macrophages and primary mouse bone marrow-derived macrophages (BMMs) was investigated.
Tuija Turpeinen, Riina Nieminen, Ville Taimi, Taina Heittola, Outi Sareila, Andrew R. Clark, Eeva Moilanen, Riku Korhonen   +7 more
doaj   +1 more source

MAP kinase kinase 1 (MAP2K1; MEK1); MAP kinase kinase 2 (MAP2K2; MEK2) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source