Results 51 to 60 of about 288,351 (166)
Journal of Neuroinflammation, 2010 Background Amyloid precursor protein (APP) is a ubiquitously expressed cell surface protein reported to be involved in mediating cell-cell or cell-matrix interactions.
Combs Colin K, Sondag Cindy M
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p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
Cell Stress, 2021 Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun +6 more
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PLoS ONE, 2013 Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying
Antonio J Ruiz-Alcaraz +6 more
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Regulation of innate immune response by MAP kinase phosphatase-1 [PDF]
Cellular Signalling, 2007 Mitogen-activated protein (MAP) kinase cascades are signal transduction pathways that play pivotal regulatory roles in the biosynthesis of pro-inflammatory cytokines. MAP kinase phosphatase (MKP)-1, an archetypal member of the MKP family, is essential for the dephosphorylation/deactivation of MAP kinases p38 and JNK.
Xianxi, Wang, Yusen, Liu
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Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells
Journal of Neuroinflammation, 2010 Background Interleukin (IL)-6 plays a pivotal role in a variety of CNS functions such as the induction and modulation of reactive astrogliosis, pathological inflammatory responses and neuroprotection.
Dohi Shuji +5 more
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Exploitation of Host Epithelial Signaling Networks by Respiratory Bacterial Pathogens
Journal of Pharmacological Sciences, 2003 Although tremendous effort has been put towards identifying the surface molecules of nontypeable Haemophilus influenzae (NTHi) for vaccine development over the past decades, it is only recently that we have begun to appreciate the intricate host ...
Jian-Dong Li
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Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase. [PDF]
PLoS ONE, 2013 The pathogenesis of interstitial cystitis/painful bladder syndrome (IC/PBS) is multifactorial, but likely involves urothelial cell dysfunction and mast cell accumulation in the bladder wall.
John O Marentette +5 more
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Journal of Pharmacological Sciences, 2012 Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family.
Masanori Yoshizumi +6 more
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MAP Kinase PrMPK9-1 Contributes to the Self-Incompatibility Response [PDF]
Plant Physiology, 2017 Mitogen-activated protein kinases (MAPKs) form important signaling modules for a variety of cellular responses in eukaryotic cells. In plants, MAPKs play key roles in growth and development as well as in immunity/stress responses. Pollen-pistil interactions are critical early events regulating pollination and fertilization and involve many signaling ...
Lijun Chai +6 more
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Activation of adherent vascular neutrophils in the lung during acute endotoxemia
Respiratory Research, 2002 Background Neutrophils constitute the first line of defense against invading microorganisms. Whereas these cells readily undergo apoptosis under homeostatic conditions, their survival is prolonged during inflammatory reactions and they become ...
Laskin Jeffrey D +5 more
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