Results 31 to 40 of about 288,351 (166)

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1 [PDF]

Current Biology, 1999
Activation of the various mitogen-activated protein (MAP) kinase pathways converts many different extracellular stimuli into specific cellular responses by inducing the phosphorylation of particular groups of substrates. One important determinant for substrate specificity is likely to be the amino-acid sequence surrounding the phosphorylation site ...
Gavin Perrin, Anne-Claude, Nebreda, Angel R.   +1 more
openaire   +2 more sources

Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells

Journal of Neuroinflammation, 2011
Background Peripheral-type benzodiazepine receptor (PBR) expression levels are low in normal human brain, but their levels increase in inflammation, brain injury, neurodegenerative states and gliomas.
Iida Hiroki, Kozawa Osamu, Tanabe Kumiko
doaj   +1 more source

Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C. [PDF]

Endocrinology, 1999
We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. In the present study, we further investigated the mechanism behind IL-1alpha-induced IL-6 synthesis in ...
M, Miwa, O, Kozawa, H, Tokuda, T, Uematsu   +3 more
openaire   +3 more sources

Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners

Journal of Pharmacological Sciences, 2005
We found that striptease-positive mast cells were abundant in the invasive front of human colon adenocarcinoma by examining 30 cases. Because tryptase has been suggested to be the agonist proteinase for protease-activated receptor-2 (PAR-2), we ...
Masanori Yoshii, Atsushi Jikuhara, Shuji Mori, Hiromi Iwagaki, Hideo K. Takahashi, Masahiro Nishibori, Noriaki Tanaka   +6 more
doaj   +1 more source

Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.

Journal of Biological Chemistry, 1994
In KB epidermoid cells, we previously showed that interleukin-1 alpha (IL-1) and various mitogens activate the mitogen-activated protein (MAP) kinases ERK1 and ERK2, which phosphorylate both myelin basic protein (MBP) and a peptide containing Thr669 of the epidermal growth factor receptor.
T A, Bird, J M, Kyriakis, L, Tyshler, M, Gayle, A, Milne, G D, Virca   +5 more
openaire   +2 more sources

Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans

Neural Development, 2007
Background The left and right AWC olfactory neurons in Caenorhabditis elegans differ in their functions and in their expression of chemosensory receptor genes; in each animal, one AWC randomly takes on one identity, designated AWCOFF, and the ...
Katsura Isao, Ishihara Takeshi, Torayama Ichiro, VanHoven Miri K, Saheki Yasunori, Bauer Huang Sarah L, van der Linden Alexander, Sengupta Piali, Bargmann Cornelia I   +8 more
doaj   +1 more source

Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade

Journal of Lipid Research, 2000
The classic sterol regulatory cis element (sre-1) in the LDL receptor promoter mediates sterol regulatory element binding protein (SREBP)-binding and the effects of insulin and platelet derived growth factor (PDGF).
Jörg Kotzka, Dirk Müller-Wieland, Gunther Roth, Lorena Kremer, Martina Munck, Sandra Schürmann, Birgit Knebel, Wilhelm Krone   +7 more
doaj   +1 more source

The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis

eLife, 2016
Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood.
Saravanapriah Nadarajan, Firaz Mohideen, Yonatan B Tzur, Nuria Ferrandiz, Oliver Crawley, Alex Montoya, Peter Faull, Ambrosius P Snijders, Pedro R Cutillas, Ashwini Jambhekar, Michael D Blower, Enrique Martinez-Perez, J Wade Harper, Monica P Colaiacovo   +13 more
doaj   +1 more source

Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning

Cell Reports, 2018
Summary: C. elegans vulval precursor cell (VPC) fates are patterned by an epidermal growth factor (EGF) gradient. High-dose EGF induces 1° VPC fate, and lower dose EGF contributes to 2° fate in support of LIN-12/Notch. We previously showed that the EGF 2°
Hanna Shin, Rebecca E.W. Kaplan, Tam Duong, Razan Fakieh, David J. Reiner   +4 more
doaj   +1 more source

Induction of thyroid gene expression and radioiodine uptake in melanoma cells: novel therapeutic implications. [PDF]

PLoS ONE, 2009
Both the MAP kinase and PI3K/Akt pathways play an important role in the pathogenesis of melanoma. We conducted the present study to test the hypothesis that targeting the two pathways to potently induce cell inhibition accompanied with thyroid iodide ...
Peng Hou, Dingxie Liu, Meiju Ji, Zhi Liu, James M Engles, Richard L Wahl, Mingzhao Xing   +6 more
doaj   +1 more source