Results 11 to 20 of about 288,351 (166)

Heregulin β-1 induces loss of cell-cell contact and enhances expression of MUC1 at the cell surface in HCC2998 and MKN45-1 cells. [PDF]

PLoS ONE, 2011
Signal transduction and cell responses after stimulation with heregulin β-1 (HRG) are examined in HCC2998 and MKN45-1 cells, which have been used for a model system to study the formation of signet ring carcinomas, one of poorly differentiated ...
Rintaro Okoshi, Chung-Li Shu, Sayoko Ihara, Yasuhisa Fukui   +3 more
doaj   +1 more source

Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development

Scientific Reports, 2022
Coordinating the balance between development and stress responses is critical for organismal survival. However, the cellular signaling controlling this mechanism is not well understood.
Rose Aria Malinow, Ming Zhu, Yishi Jin, Kyung Won Kim   +3 more
doaj   +1 more source

HAM-5 functions as a MAP kinase scaffold during cell fusion in Neurospora crassa. [PDF]

PLoS Genetics, 2014
Cell fusion in genetically identical Neurospora crassa germlings and in hyphae is a highly regulated process involving the activation of a conserved MAP kinase cascade that includes NRC-1, MEK-2 and MAK-2. During chemotrophic growth in germlings, the MAP
Wilfried Jonkers, Abigail C Leeder, Charles Ansong, Yuexi Wang, Feng Yang, Trevor L Starr, David G Camp, Richard D Smith, N Louise Glass   +8 more
doaj   +1 more source

A Caenorhabditis elegans MAP kinase kinase, MEK‐1, is involved in stress responses [PDF]

The EMBO Journal, 2000
The c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family, was shown to be involved in the response to various stresses in cultured cells. However, there is little in vivo evidence indicating a role for a JNK pathway in the stress response of an organism. We identified the Caenorhabditis elegans mek-1 gene, which
Koga, Makoto, Zwaal, Richard, Guan, Kun‐liang, Avery, Leon, Ohshima, Yasumi   +4 more
openaire   +3 more sources

Regulation of the MAP kinase cascade in PC12 cells: B‐Raf activates MEK‐1 (MAP kinase or ERK kinase) and is inhibited by cAMP [PDF]

FEBS Letters, 1995
In PC12 cells, cAMP stimulates the MAP kinase pathway by an unknown mechanism. Firstly, we examined the role of calcium ion mobilization and of protein kinase C in cAMP‐stimulated MAP kinase activation. We show that cAMP stimulates p44mapk independently of these events. Secondly, we studied the role of B‐Raf in this process.
Peraldi, P, Frödin, M, Barnier, J V, Calleja, V, Scimeca, J C, Filloux, C, Calothy, G, Van Obberghen, E   +7 more
openaire   +2 more sources

Insulin signaling inhibits the 5-HT_2C receptor in choroid plexus via MAP kinase

BMC Neuroscience, 2003
Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang, DePaoli-Roach Anna A, Marshall Mark S, Bye Leighan S, Zhang Shengwen, Hurley Joyce H, Fox Aaron P, Yu Lei   +7 more
doaj   +1 more source

Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans. [PDF]

PLoS Pathogens, 2013
Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear
Feng Liu, Chen-Xi He, Li-Jun Luo, Quan-Li Zou, Yong-Xu Zhao, Ratni Saini, San-Feng Han, Hans-Joachim Knölker, Li-Shun Wang, Bao-Xue Ge   +9 more
doaj   +1 more source

The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. [PDF]

PLoS ONE, 2009
The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses.
Katherine R Schouest, Yasuhiro Kurasawa, Tokiko Furuta, Naoki Hisamoto, Kunihiro Matsumoto, Jill M Schumacher   +5 more
doaj   +1 more source

Methyl lucidone inhibits airway inflammatory response by reducing TAK1 activity in human bronchial epithelial NCI–H292 cells

Heliyon, 2023
Background: Methyl lucidone (ML), a methyl derivative of lucidone, has anti-inflammatory properties. However, the molecular mechanisms that reduce the inflammatory effect of ML in human lung epithelial cells remain unkown.
Eun Sol Oh, Hyunju Ro, Hyung Won Ryu, Yu Na Song, Ji-Yoon Park, Namho Kim, Hae-Young Kim, Seon Min Oh, Su-Yeon Lee, Doo-Young Kim, Sooil Kim, Sung-Tae Hong, Mun-Ock Kim, Su Ui Lee   +13 more
doaj   +1 more source

Identification of the sites in MAP kinase kinase‐1 phosphorylated by p74raf‐1.

The EMBO Journal, 1994
Many growth factors whose receptors are protein tyrosine kinases stimulate the MAP kinase pathway by activating first the GTP-binding protein Ras and then the protein kinase p74raf-1. p74raf-1 phosphorylates and activates MAP kinase kinase (MAPKK). To understand the mechanism of activation of MAPKK, we have identified Ser217 and Ser221 of MAPKK1 as the
Alessi, D. R., Saito, Y., Campbell, D. G., Cohen, P., Sithanandam, G., Rapp, U., Ashworth, A., Marshall, C. J., Cowley, S.   +8 more
openaire   +3 more sources