MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti‐tumour immunity [PDF]
Journal of Extracellular VesiclesExtracellular vesicles (EVs) mediate intercellular communication in many physiologic processes and can modulate immune responses in individuals with cancer. Most studies of EVs in cancer have focused on their tumour promoting properties.
Stephen C. Searles +9 more
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The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells [PDF]
FEBS Letters, 1994 The residues on MAP kinase kinase‐1 (MAPKK1) phosphorylated by MAP kinase in vitro have been identified as Thr‐291 and Thr‐385. Both threonines are phosphorylated in PC12 cells and the 32P‐labelling of each residue increases after stimulation with nerve growth factor (NGF).
Philip Cohen +2 more
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Frontiers in Microbiology, 2021 Mitogen-activated protein (MAP) kinase pathways function as signaling hubs that are integral for many essential cellular processes, including sexual development.
Nan Lan +12 more
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HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts. [PDF]
PLoS ONE, 2017 Heat shock protein 90 (HSP90) that is ubiquitously expressed in various tissues, is recognized to be a major molecular chaperone. We have previously reported that prostaglandin F2α (PGF2α), a potent bone remodeling mediator, stimulates the synthesis of ...
Kazuhiko Fujita +9 more
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Feedback Regulation of Raf-1 and Mitogen-activated Protein Kinase (MAP) Kinase Kinases 1 and 2 by MAP Kinase Phosphatase-1 (MKP-1) [PDF]
Journal of Biological Chemistry, 1998 Inactivation of growth factor-regulated mitogen-activated protein (MAP) kinases (ERK1 and ERK2) has been proposed to occur in part through dephosphorylation by the dual specificity MAP kinase phosphatase-1 (MKP-1), an immediate early gene that is induced by mitogenic signaling.
P S, Shapiro, N G, Ahn
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The NDR kinase scaffold HYM1/MO25 is essential for MAK2 map kinase signaling in Neurospora crassa. [PDF]
PLoS Genetics, 2012 Cell communication is essential for eukaryotic development, but our knowledge of molecules and mechanisms required for intercellular communication is fragmentary.
Anne Dettmann +5 more
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The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment [PDF]
Cancer and Metastasis Reviews, 2010 Chemotherapy resistance is an important problem often encountered during the course of breast cancer treatment. In order to design rational and efficacious therapies, the molecular mechanisms used by cells to develop resistance must be investigated. One mechanism employed by cancer cells is to alter cell signaling.
Kelly K, Haagenson, Gen Sheng, Wu
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Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP [PDF]
Nature, 1999 Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different cell types. Here we describe a Raf-1-interacting protein, isolated using a yeast two-hybrid screen.
Yeung, K. +11 more
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Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
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MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites
FEBS Open Bio, 2022 Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of l‐arginine to nitric oxide (NO) in response to a significant number of signaling pathways.
Xzaviar K. V. Solone +9 more
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